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The role of hedgehog signaling in personality formation

Research Project

Project/Area Number 17K10048
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionChiba University

Principal Investigator

Uchikawa Hideki  千葉大学, 大学院医学研究院, 特任講師 (80618059)

Co-Investigator(Kenkyū-buntansha) 藤井 克則  千葉大学, 大学院医学研究院, 講師 (70344992)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsヘッジホッグシグナル / Gorlin症候群 / パーソナリティー / セロトニン / 扁桃体 / 損害回避 / ゴーリン症候群 / 脳・神経 / 発生・分化
Outline of Final Research Achievements

The personality of Gorlin syndrome who experienced increased sonic hedgehog (Shh) signaling from the prenatal period was investigated in humans and model mice. In humans, a study using the Japanese version of Temperamnt and Character Inventory, showed significantly lower harm avoidance related to serotonin in patients with Gorlin syndrome. The left amygdala volume, which is closely related to serotonin, was significantly reduced in these patients. In model mice, there was a negative correlation between serotonin and its metabolite 5HIAA in the brain, and the amygdala volume was significantly enlarged on the left side. Behavioral experiments tended to have less fear response. It was suggested that the Shh signaling plays an important role in personality formation through serotonin metabolism.

Academic Significance and Societal Importance of the Research Achievements

発生過程や腫瘍形成において重要な役割のあるソニックヘッジホッグ(Shh)シグナルのパーソナリティー形成への関与について研究した。胎児期から出生後もShhシグナルが亢進しているGorlin症候群患者やそのモデルマウスを対象に調査や実験を行い、Shhシグナルはパーソナリティ形成においてセロトニン代謝を通して重要な役割があることが示唆された。この研究からパーソナリティー形成の機序解明の一助となり、さらにはパーソナリティーに関する医療的もしくは社会的問題に役立つことが期待される。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (6 results)

All 2021 2019 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (4 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Specific temperament in patients with nevoid basal cell carcinoma syndrome2021

    • Author(s)
      Uchikawa Hideki、Fujii Katsunori、Shiohama Tadashi、Nakazato Michiko、Shimizu Eiji、Miyashita Toshiyuki、Shimojo Naoki
    • Journal Title

      Pediatrics International

      Volume: 63 Issue: 2 Pages: 177-182

    • DOI

      10.1111/ped.14419

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gorlin症候群の臨床症状2019

    • Author(s)
      内川英紀
    • Journal Title

      医学のあゆみ

      Volume: 268 Pages: 118-122

    • Related Report
      2018 Research-status Report
  • [Presentation] Gorlin症候群モデルマウスにおける扁桃体の解析2021

    • Author(s)
      内川英紀、塩浜直、佐原佑治、松田真悟、清水栄司、新田展大、青木伊知男、藤井克則
    • Organizer
      第63回日本小児神経学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Specific personality and amygdala volume in Gorlin syndrome.2019

    • Author(s)
      Hideki Uchikawa, Katsunori Fujii, Tadashi Shiohama, Naoki Shimojo.
    • Organizer
      13th EPNS Congress
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Gorlin症候群における扁桃体と中脳の検討2018

    • Author(s)
      内川英紀、藤井克則、塩浜直、下条直樹
    • Organizer
      第60回日本小児神経学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Temperament and Character in Patients with Gorlin syndrome.2017

    • Author(s)
      Uchikawa H, Fujii K, Shiohama T, Shimojo N.
    • Organizer
      14th Asian and Oceanian Congress of Child Neurology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2022-01-27  

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