Novel machanism of mitochondrial disease based on noncoding RNA
| Project/Area Number |
17K10060
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Saitama Medical University |
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Principal Investigator |
Mizuno Yosuke 埼玉医科大学, 医学部, 准教授 (30406532)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | ミトコンドリア病 / 非コードRNA / 呼吸差酵素 / マイクロRNA / 呼吸差酵素複合体 / 呼吸鎖酵素 / ミトコンドリア / miRNA |
|---|
| Outline of Final Research Achievements |
Functional loss of mitochondrial genes which are involved in mitochondrial fission, fusion, energy generation and stress regulation can change the expression level of several noncoding RNAs which could involve in mitochondrial function. To identify those RNAs, we obtained RNA samples from human cultured cells in which dysfunction of crucial mitochondrial genes was introduced. By expression analysis, we identified several messenger RNAs, long noncoding RNAs and microRNAs whose expression level was changed by the results of dysfunction of crucial mitochondrial genes.
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| Academic Significance and Societal Importance of the Research Achievements |
ミトコンドリアの分裂や融合に関わる遺伝子を抑制することにより、共通して発現が変動する長鎖非コードRNAやマイクロRNAも複数検出することが出来た。この中に、ミトコンドリア機能を制御したり影響を及ぼし、ひいてはミトコンドリア病の発症要因にもなるRNAが含まれていると考えられる。
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Cardiomyopathy in children with mitochondrial disease: Prognosis and genetic background2019
Author(s)
Atsuko Imai-Okazaki, Yoshihito Kishita, Masakazu Kohda, Yosuke Mizuno, Takuya Fushimi, Ayako Matsunaga, Yukiko Yatsuka, Tomoko Hirata, Hiroko Harashima, Atsuhito Takeda, Akihiro Nakaya, Yasushi Sakatai, Shigetoyo Kogaki, Akira Ohtake, Kei Murayama, YasushiOkazaki
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Journal Title
International Journal of Cardiology
Volume: 279
Pages: 115-121
Related Report
Peer Reviewed
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[Presentation] Prognosis and Genetic Background of Mitochondrial Cardiomyopathy in 226 Mitochondrial Disease Patients2019
Author(s)
Atsuko Imai-Okazaki, Yoshihito Kishita, Masakazu Kohda, Takuya Fushimi, Ayako Matsunaga, Yosuke Mizuno, Yukiko Yatsuka, Tomoko Hirata, Hiroko Harashima, Atsuhito Takeda, Akihiro Nakaya, Shigetoyo Kogaki, Yasushi Sakata, Akira Ohtake, Kei Murayama, Yasushi Okazaki
Organizer
第84回日本循環器学会学術集会
Related Report
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