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Cognitiveneuroscience of reward prediction and empathy in developmental disorders

Research Project

Project/Area Number 17K10073
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionUniversity of Yamanashi

Principal Investigator

AIHARA Masao  山梨大学, 大学院総合研究部, 教授 (30242639)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords共感 / 神経生理学 / 発達障害 / 脳波周波数解析 / 認知神経科学 / 社会脳 / 前頭葉 / 報酬予測 / 前頭葉機能
Outline of Final Research Achievements

The lack of empathy makes the individual unable to function socially. The prefrontal cortex, which is critical for the organization of affective/cognitive processes, is among the last cortical regions to reach full functional maturity. Therefore, early frontal lesions can result in deficits not immediately apparent but predisposing to later developmental problems such as problems with moral judgment. To fully appreciate the implications of developmental problems in children, hypothesis-driven studies are needed to explore functions such as epmathy. We recently have studied emotional tasks for use as an activation procedure representing pleasure and unpleasure feelings, which are respectively linked to left and right frontal systems. On the basis of these results, we can examine the affective, empathic component electrophysiologically in both healty contlos and developmental disorders. These findings are presented by symposium in the congress and english papers.

Academic Significance and Societal Importance of the Research Achievements

発達障害は前頭葉の機能障害であることが神経心理学的に提唱されてきている。前頭葉は認知・情動処理系の相互作用から将来の意思決定や自己と他者をつなぐ共感に関わる脳領域であることが認知神経科学的に次第に明らかとなってきた。
本研究の目的は、自己の意思決定や他者への共感に関わる神経心理学的課題遂行時の認知・情動処理系を解析し、さらに対象者と観察者を神経生理学的に同時に測定することで、両処理系の相互作用に関わる脳内情報処理過程と臨界期を定型発達児において定量化することにあった。発達障害を学際的な研究対象とすることで、診断と治療に対する評価基準と教育方針を認知神経科学的に確立することを目標としている。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (27 results)

All 2020 2019 2018 2017

All Journal Article (11 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 6 results,  Open Access: 8 results) Presentation (14 results) (of which Invited: 7 results) Book (2 results)

  • [Journal Article] 発達障害2020

    • Author(s)
      相原正男
    • Journal Title

      Cinical neuroscience

      Volume: 38 Pages: 196-199

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 前頭葉と神経発達症候群2019

    • Author(s)
      相原正男
    • Journal Title

      脳神経内科

      Volume: 51 Pages: 539-547

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 認知神経科学よりみた社会脳(social brain)の発達―発達障害を理解するためにー2019

    • Author(s)
      相原正男
    • Journal Title

      千葉小児科医会誌

      Volume: 51 Pages: 33-37

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Systematic review of the screening, diagnosis, and management of ADHD in children with epilepsy.2018

    • Author(s)
      Auvin S, 1 Wirrell E, Donald KA, Berl M, Hartmann H, Valente KD, Van Bogaert P, Cross JH, Osawa M, Kanemura H, Aihara M, Guerreiro MM, Samia P, Vinayan KP, Smith ML, Carmant L, Kerr M, Hermann B, Dunn D, Wilmshurst JM.
    • Journal Title

      Epilepsia

      Volume: 59 Issue: 4 Pages: 1867-1880

    • DOI

      10.1111/epi.13671

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 心の健やかな発達/つまずきと脳ー感情ー.特別企画:子どもの発達と脳.2018

    • Author(s)
      相原正男
    • Journal Title

      こころの科学

      Volume: 200 Pages: 34-40

    • Related Report
      2018 Research-status Report
    • Open Access
  • [Journal Article] 脳機能検査. 特集「注意欠如/多動症」.2018

    • Author(s)
      相原正男
    • Journal Title

      日本臨床

      Volume: 76 Pages: 591-596

    • Related Report
      2018 Research-status Report
    • Open Access
  • [Journal Article] NIRSを用いた小児の前頭葉機能評価.2018

    • Author(s)
      石井佐綾香、反頭智子、加賀佳美、相原正男.
    • Journal Title

      臨床神経生理学

      Volume: 46 Pages: 132-138

    • NAID

      130007382957

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Developmental changes in autonomic emotional response during an executive functional task: a pupillometric study during Wisconsin card sorting test.2017

    • Author(s)
      Ohyama T, Kaga Y, Goto Y, Aoyagi K, Ishii S, Kanemura H, Sugita K, Aihara M.
    • Journal Title

      Brain Dev

      Volume: 39 Pages: 187-185

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Disinhibition in children with ADHD: changes in [oxy-Hb] on NIRS during “rock, paper, scissors2 task.2017

    • Author(s)
      Ishi I S, Kaga Y, Tando T, Aoyagi K, Sano F, Kanemura H, Sugita k, Aihara M.
    • Journal Title

      Brain Dev

      Volume: 39 Pages: 395-402

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Factors associated with attention deficit hyperactivity disorder in children with frontal lobe epilepsy.2017

    • Author(s)
      Kanemura H, Sano F, Ohyama T, Sugita K, Aihara M.
    • Journal Title

      J Pediatr Epilepsy

      Volume: 6 Pages: 133-140

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Developmental changes in autonomic responses are associated with future reward/punishment expectations: a study of sympathetic skin responses in the Markov decision task.2017

    • Author(s)
      Hosaka H, Aoyagi K, Kaga Y, Kanemura H, Sugita K, Aihara M.
    • Journal Title

      Brain Dev

      Volume: 39 Pages: 573-582

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 快・不快に関する共感の電気生理学的研究2019

    • Author(s)
      青柳閣郎、後藤裕介、石井佐綾香、大山哲男、相原正男
    • Organizer
      第61回日本小児神経学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 自閉スペクトラム症における共感の神経生理学的研究2019

    • Author(s)
      青柳閣郎、後藤裕介、石井佐綾香、大山哲夫、相原正男
    • Organizer
      第24回認知神経科学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 共感の神経生理学的研究 ~脳波周波数分析を用いた快・不快に関する検討~2019

    • Author(s)
      後藤裕介、青柳閣郎、石井佐綾香、大山哲男、相原正男
    • Organizer
      第24回認知神経科学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 自閉症スペクトラム(autistic spectrum disorders; ASD)における情動反応の神経生理学的研究~脳波周波数解析による検討~2019

    • Author(s)
      青柳閣郎、後藤裕介、石井佐綾香、相原正男
    • Organizer
      第49回日本臨床神経生理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 認知神経科学よりみた社会脳(social brain)の発達―発達障害を理解するためにー2019

    • Author(s)
      相原正男
    • Organizer
      千葉県小児科医会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 共感に関わる認知神経科学的研究2019

    • Author(s)
      相原正男
    • Organizer
      分野横断的融合研究プロジェクト研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 子どもの心と脳の育ちー自尊心を育むためにー2019

    • Author(s)
      相原正男
    • Organizer
      山梨県教育委員会主催:しなやかな心の育成フォーラム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 認知神経科学よりみた社会脳の発達とその障害2018

    • Author(s)
      相原正男
    • Organizer
      関西医科大学臨床研修会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 子どもの心を地域で育む2018

    • Author(s)
      相原正男
    • Organizer
      山梨県小児医会学術研修会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 快・不快に関する共感の神経心理学的研究 ~脳波周波数解析を用いた検討~2018

    • Author(s)
      後藤裕介、青柳閣郎、石井佐綾香、大山哲男、相原正男
    • Organizer
      第48回日本臨床神経生理学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 脳波周波数解析を用いた共感における前頭葉機能の側性化についての検討2018

    • Author(s)
      大山哲男、後藤裕介、青柳閣郎、金村英秋、相原正男
    • Organizer
      第60回日本小児神経学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 地域連携を通して心を育む.2017

    • Author(s)
      相原正男
    • Organizer
      第18回山梨大学看護学会学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 小児神経生理学における研究・実践教育活動. 特別企画:臨床神経生理-小さな波から大きな‘みらい’.2017

    • Author(s)
      相原正男
    • Organizer
      第47回日本臨床神経生理学会学術大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 子どもの心と脳の育ち2017

    • Author(s)
      相原正男
    • Organizer
      平成29年度子どもの心の健康づくりシンポジウム. 山梨県教育委員会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] 神経心理検査ベーシック2019

    • Author(s)
      相原正男
    • Total Pages
      319
    • Publisher
      中外医学
    • Related Report
      2019 Annual Research Report
  • [Book] 神経心理検査ベーシック2019

    • Author(s)
      相原正男
    • Total Pages
      336
    • Publisher
      中外医学社
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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