Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Outline of Final Research Achievements |
Local phosphorus production system and role of alkaline phosphatase in bone and cartilage mineralization remain to be elucidated. Osteoblast-mediated mineralization study using human bone marrow derived mesenchymal stem cells and induced pluripotent stem cells derived from patients with hypophosphatasia suggested that alkaline phosphatase activity, phosphorus levels, pyrophosphate levels and phosphorus/pyrophosphate ratio affect bone mineralization and osteoblastic differentiation markers.
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