Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Outline of Final Research Achievements |
Maternal immune activation (MIA) induced by pregnant bacterial or viral infection has been considered as one of the risk factors of autistic spectrum disorder (ASD). To investigate a brain function of MIA-affected offspring, we performed resting-state functional magnetic resonance imaging (rs-fMRI) and positron emission tomography (PET). MIA model was generated by intraperitoneal injection of polyinosinic:polycytidylic acid (20 mg/kg) in pregnant mice on gestational day 12.5. The rs-fMRI study revealed that the MIA-affected offspring with social deficit had hyper-connectivity of functional networks with over and local preferred connectivity, which were similar to those of human studies in ASD patients. PET imaging showed the MIA model had low glucometabolism in the brainstem. These results suggest that abnormal functional network connectivities associated with glucometaboic activity may be crucial in the appearance of the behavioral phenotype in the MIA model.
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