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Analysis of microbiota and molecular pathogenesis in primary immunodeficiency diseases

Research Project

Project/Area Number 17K10099
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Kanegane Hirokazu  東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座教授 (00293324)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords原発性免疫不全症 / 腸内細菌叢 / 炎症性腸疾患 / A20ハプロ不全症 / XIAP欠損症 / TNFAIP3ハプロ不全 / CTLA4ハプロ不全
Outline of Final Research Achievements

Primary immunodeficiency disease (PID) is an inherited disorder in which immune system is impaired. Clinical heterogeneity of PID may be associated with additional factors, although it has monogenic defect. We supposed that the heterogeneity of PID might be linked with aberrant intestinal microbiome. Therefore, we searched intestinal microbiome using next-generation sequencing in patients and their family members with A20 haploinsufficiency (HA20) and XIAP deficiency. A subset of bacteria might affect the pathogenesis of HA20. In XIAP-deficient patients with inflammatory bowel disease, intestinal microbiome was normalized after hematopoietic cell transplantation.

Academic Significance and Societal Importance of the Research Achievements

HA20とXIAP欠損症という限られたPIDであるが、腸内細菌叢がその病態形成に関わっていることが明らかになった。臨床的多様性を有する他のPIDについても腸内細菌叢を調べることによってその病態が明らかになることが期待される。また造血細胞移植の成功によって腸内細菌叢が正常化していることから、免疫の再構築と腸内細菌叢との関係が明らかとなった。今後はマウスモデルを用いて腸内細菌叢を調べることによって新規治療開発も期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (43 results)

All 2020 2019 2018 2017

All Journal Article (43 results) (of which Int'l Joint Research: 15 results,  Peer Reviewed: 43 results,  Open Access: 24 results,  Acknowledgement Compliant: 3 results)

  • [Journal Article] Disseminated fusariosis in a child after haploidentical hematopoietic stem cell transplantation.2020

    • Author(s)
      Hoshino A, Tokoro S, Akashi T, Inoue M, Takagi M, Imai K, Kanegane H, Muraosa Y, Kamei K, Morio T
    • Journal Title

      Pediatr Int

      Volume: 62 Issue: 3 Pages: 419-420

    • DOI

      10.1111/ped.14097

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nationwide retrospective review of hematopoietic stem cell transplantation in children with refractory Langerhans cell histiocytosis2020

    • Author(s)
      Kudo K, Maeda M, Suzuki N, Kanegane H, Ohga S, Ishii E, Shioda Y, Imamura T, Imashuku S, Tsunematsu Y, Endo M, Shimada A, Koga Y, Hashii Y, Noguchi M, Inoue M, Tabuchi K, Morimoto A
    • Journal Title

      International Journal of Hematology

      Volume: 111 Issue: 1 Pages: 137-148

    • DOI

      10.1007/s12185-019-02760-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] X-linked lymphoproliferative syndrome in mainland China: review of clinical, genetic, and immunological characteristic2020

    • Author(s)
      Xu T, Zhao Q, Li W, et al.
    • Journal Title

      Eur J Pediatr

      Volume: 179 Issue: 2 Pages: 327-338

    • DOI

      10.1007/s00431-019-03512-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Early Surgery Is Feasible for a Very Large Congenital Infantile Fibrosarcoma Associated With Life Threatening Coagulopathy: A Case Report and Literature Review.2019

    • Author(s)
      Alias H, Abdul Rashid AH, Lau SCD, Loh C-K, Sapuan J, Ibrahim S, Md Zin RR, Chow YP, Kanegane H, Eguchi M
    • Journal Title

      Frontiers in Pediatrics

      Volume: 7 Pages: 529-529

    • DOI

      10.3389/fped.2019.00529

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Novel AP3B1 compound heterozygous mutations in a Japanese patient with Hermansky?Pudlak syndrome type 22019

    • Author(s)
      Nishikawa Takuro、Okamura Ken、Moriyama Mizuki、Watanabe Kenji、Ibusuki Atsuko、Sameshima Seiji、Masamoto Izumi、Yamazaki Ieharu、Tanita Kay、Kanekura Takuro、Kanegane Hirokazu、Suzuki Tamio、Kawano Yoshifumi
    • Journal Title

      The Journal of Dermatology

      Volume: 47 Issue: 2 Pages: 185-189

    • DOI

      10.1111/1346-8138.15177

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer’s Patches2019

    • Author(s)
      Kunimura K, Sakata D, Tun X, Uruno T, Ushijima M, Katakai T, Shiraishi A, Aihara R, Kamikaseda Y, Matsubara K, Kanegane H, Sawa S, Eberl G, Ohga S, Yoshikai Y, Fukui Y.
    • Journal Title

      Cell Reports

      Volume: 29 Issue: 9 Pages: 2823-2834

    • DOI

      10.1016/j.celrep.2019.10.091

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prominent Dermal Langerhans Cells in an Omenn Syndrome Patient With a Novel Mutation in the IL2RG Gene2019

    • Author(s)
      Ibusuki Atsuko、Nishikawa Takuro、Hiraki Tsubasa、Okano Tsubasa、Imai Kohsuke、Kanegane Hirokazu、Ohnishi Hidenori、Kato Zenichiro、Fujii Kazuyasu、Tanimoto Akihide、Kawano Yoshifumi、Kanekura Takuro
    • Journal Title

      The Journal of Dermatology

      Volume: 46 Issue: 11 Pages: 1019-1023

    • DOI

      10.1111/1346-8138.15054

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hematopoietic stem cell transplantation recovers insulin deficiency in type 1 diabetes mellitus associated with IPEX syndrome2019

    • Author(s)
      Yamauchi T, Takasawa K, Kamiya T, et al.
    • Journal Title

      Pediatr Diabetes

      Volume: 20 Issue: 7 Pages: 1035-1040

    • DOI

      10.1111/pedi.12895

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Robust and highly efficient hiPSC generation from patient non-mobilized peripheral blood-derived CD34+ cells using the auto-erasable Sendai virus vector.2019

    • Author(s)
      Okumura T, Horie Y, et al.
    • Journal Title

      Stem Cell Res Ther.

      Volume: 10 Issue: 1 Pages: 185-185

    • DOI

      10.1186/s13287-019-1273-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of autoantibodies using human proteome microarrays in patients with IPEX syndrome2019

    • Author(s)
      Hoshino Akihiro、Kanegane Hirokazu、Nishi Masanori、Tsuge Ikuya、Tokuda Kiriko、Kobayashi Ichiro、Imai Kohsuke、Morio Tomohiro、Takagi Masatoshi
    • Journal Title

      Clinical Immunology

      Volume: 203 Pages: 9-13

    • DOI

      10.1016/j.clim.2019.03.011

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A synonymous splice site mutation in IL2RG gene causes late-onset combined immunodeficiency2019

    • Author(s)
      Yamashita M, Wakatsuki R, Kato T, Okano T, Yamanishi S, Mayumi N, Tanaka M, Ogura Y, Kanegane H, Nonoyama S, Imai K, Morio T
    • Journal Title

      Int J Hematol

      Volume: 109 Issue: 5 Pages: 603-611

    • DOI

      10.1007/s12185-019-02619-9

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Outcomes of children with hemophagocytic lymphohistiocytosis treated using HLH-2004 protocol in Japan2019

    • Author(s)
      Yanagaisawa R, Matsuda K, Ohga S, Kanegane H, Morimoto A, Saito AM, Horibe K, Ishii E, Nakazawa Y
    • Journal Title

      International Journal of Hematology

      Volume: 109 Issue: 5 Pages: 612-617

    • DOI

      10.1007/s12185-019-02612-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atypical SIFD with novel TRNT1 mutations: a case study on the pathogenesis of B-cell deficiency2019

    • Author(s)
      Kumaki Eri、Tanaka Keisuke、Imai Kohsuke、Aoki-Nogami Yuki、Ishiguro Akira、Okada Satoshi、Kanegane Hirokazu、Ishikawa Fumihiko、Morio Tomohiro
    • Journal Title

      International Journal of Hematology

      Volume: 109 Issue: 4 Pages: 382-389

    • DOI

      10.1007/s12185-019-02614-0

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] An 18-Year-Old Male With X-linked Lymphoproliferative Syndrome Type 1 Who Developed Primary Central Nervous System Lymphoma 6 Months After Primary Epstein-Barr Virus Infection2019

    • Author(s)
      Kusano N, Sakata N, Sugimoto K, et al.
    • Journal Title

      J Pediatr Hematol Oncol

      Volume: 41 Issue: 8 Pages: e538-e541

    • DOI

      10.1097/mph.0000000000001424

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] X-linked agammaglobulinemia (XLA):Phenotype, diagnosis, and therapeutic challenges around the world.2019

    • Author(s)
      El-Sayed ZA, Abramova I, Aldave JC, Al-Herz W, Bezrodnik L, Boukari R, Bousfiha AA, Cancrini C, Condino-Neto A, Dbaibo G, Derfalvi B, Dogu F, Edgar JDM, Eley B, El-Owaidy RH, Espinosa-Padilla SE, Galal N, Haerynck F, Hanna-Wakim R, Hossny E,et al.
    • Journal Title

      World Allergy Organ J

      Volume: 12 Issue: 3 Pages: 100018-100018

    • DOI

      10.1016/j.waojou.2019.100018

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Epstein-Barr Virus-Associated γδ T-Cell Lymphoproliferative Disorder Associated With Hypomorphic IL2RG Mutation2019

    • Author(s)
      Tanita K, Hoshino A, Imadome K, Kamiya T, Inoue K, Okano T, Yeh TW, Yanagimachi M, Shiraishi A, Ishimura M, Schober T, Rohlfs M, Takagi M, Imai K, Takada H, Ohga S, Klein C, Morio T, Kanegane H.
    • Journal Title

      Front Pediatr

      Volume: 7 Pages: 15-15

    • DOI

      10.3389/fped.2019.00015

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modification of cellular and humoral immunity by somatically reverted T cells in X-linked lymphoproliferative syndrome type 12019

    • Author(s)
      Hoshino A, Yang X, Tanita K, Yoshida K, Ono T, Nishida N, Okuno Y, Kanzaki T, Goi K, Fujino H, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Kojima S, Morio T, Kanegane H.
    • Journal Title

      J Allergy Clin Immunol

      Volume: 143 Issue: 1 Pages: 421-424

    • DOI

      10.1016/j.jaci.2018.07.044

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inflammatory bowel diseases and primary immunodeficiency diseases2018

    • Author(s)
      Kanegane H.
    • Journal Title

      Immunol Med

      Volume: 41 Issue: 4 Pages: 154-161

    • DOI

      10.1080/25785826.2018.1556025

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hematopoietic cell transplantation for asymptomatic X-linked lymphoproliferative syndrome type 12018

    • Author(s)
      Tamura A, Uemura S, Yamamoto N, Saito A, Kozaki A, Kishimoto K, Ishida T, Hasegawa D, Hiroki H, Okano T, Imai K, Morio T, Kanegane H, Kosaka Y.
    • Journal Title

      Allergy Asthma Clin Immunol

      Volume: 14 Issue: 1 Pages: 82-82

    • DOI

      10.1186/s13223-018-0306-1

    • NAID

      120006818739

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical and Immunological Characterization of ICF Syndrome in Japan2018

    • Author(s)
      Kamae C, Imai K, Kato T, Okano T, Honma K, Nakagawa N, Yeh TW, Noguchi E, Ohara A, Shigemura T, Takahashi H, Takakura S, Hayashi M, Honma A, Watanabe S, Shigemori T, Ohara O, Sasaki H, Kubota T, Morio T, et al.
    • Journal Title

      J Clin Immunol

      Volume: 38 Issue: 8 Pages: 927-937

    • DOI

      10.1007/s10875-018-0559-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gain-of-function IKBKB mutation causes human combined immune deficiency2018

    • Author(s)
      Cardinez C, Miraghazadeh B, Tanita K, da Silva E, Hoshino A, Okada S, Chand R, Asano T, Tsumura M, Yoshida K, Ohnishi H, Kato Z, Yamazaki M, Okuno Y, Miyano S, Kojima S, Ogawa S, Andrews TD, Field MA, Burgio G,et al.
    • Journal Title

      J Exp Med

      Volume: 215 Issue: 11 Pages: 2715-2724

    • DOI

      10.1084/jem.20180639

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] High frequencies of asymptomatic Epstein-Barr virus viremia in affected and unaffected individuals with CTLA4 mutations.2018

    • Author(s)
      Hoshino A, Tanita K, Kanda K, Imadome K, Shikama Y, Yasumi T, Imai K, Takagi M, Morio T, Kanegane H.
    • Journal Title

      Clin Immunol

      Volume: 195 Pages: 45-48

    • DOI

      10.1016/j.clim.2018.07.012

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] IKBA S32 Mutations Underlie Ectodermal Dysplasia with Immunodeficiency and Severe Noninfectious Systemic Inflammation2018

    • Author(s)
      Moriya K, Sasahara Y, Ohnishi H, Kawai T, Kanegane H.
    • Journal Title

      J Clin Immunol

      Volume: 38 Issue: 5 Pages: 543-545

    • DOI

      10.1007/s10875-018-0522-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency2018

    • Author(s)
      Boutboul D, Kuehn HS, Van de Wyngaert Z, Niemela JE, Callebaut I, Stoddard J, Lenoir C, Barlogis V, Farnarier C, Vely F, Yoshida N, Kojima S, Kanegane H, Hoshino A, Hauck F, Lhermitte L, Asnafi V, Roehrs P, Chen S, Verbsky JW,et al.
    • Journal Title

      J Clin I)nvest

      Volume: 128 Issue: 7 Pages: 3071-3087

    • DOI

      10.1172/jci98164

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hematopoietic Stem Cell Transplantation for Progressive Combined Immunodeficiency and Lymphoproliferation in Activated PI3K <delta> Syndrome Type 12018

    • Author(s)
      Okano T, Imai K, ..., Nonoyama S, Morio T. et al.
    • Journal Title

      J Allergy Clin Immunol

      Volume: 印刷中 Issue: 1 Pages: 266-275

    • DOI

      10.1016/j.jaci.2018.04.032

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comprehensive molecular diagnosis of Epstein-Barr virus-associated lymphoproliferative diseases using next-generation sequencing2018

    • Author(s)
      Ono S, Nakayama M, Kanegane H, Hoshino A, Shimodera S, Shibata H, Fujino H, Fujino T, Yunomae Y, Okano T, Yamashita M, Yasumi T, Izawa K, Takagi M, Imai K, Zhang K, Marsh R, Picard C, Latour S, Ohara O, et al.
    • Journal Title

      Int J Hematol

      Volume: 108 Issue: 3 Pages: 319-328

    • DOI

      10.1007/s12185-018-2475-6

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects2018

    • Author(s)
      Schwab C, Gabrysch A, Olbrich P, Pati&ntilde;o V, Warnatz K, Wolff D, Hoshino A, Kobayashi M, Imai K, Takagi M, Dybedal I, Haddock JA, Sansom DM, Lucena JM, Seidl M, Schmitt-Graeff A, Reiser V, Emmerich F, Frede N, Bulashevska A, et al.
    • Journal Title

      J Allergy Clin Immunol

      Volume: 142 Issue: 6 Pages: 1932-1946

    • DOI

      10.1016/j.jaci.2018.02.055

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dysregulation of Epstein-Barr virus infection in hypomorphic ZAP70 mutation2018

    • Author(s)
      Hoshino A,Takashima T, Yoshida K, Morimoto A, Kawahara Y, Yeh TW, Okano T, Yamashita M, Mitsuiki N, Imai K, Sakatani T, Nakazawa A, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S,Ogawa S, Kojima S, Morio T, Kanegane H
    • Journal Title

      J Infect Dis

      Volume: 印刷中 Issue: 5 Pages: 825-834

    • DOI

      10.1093/infdis/jiy231

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Droplet Digital PCR-Based Chimerism Analysis for Primary Immunodeficiency Diseases2018

    • Author(s)
      Okano Tsubasa、Tsujita Yuki、Kanegane Hirokazu、Mitsui-Sekinaka Kanako、Tanita Kay、Miyamoto Satoshi、Yeh Tzu-Wen、Yamashita Motoi、Terada Naomi、Ogura Yumi、Takagi Masatoshi、Imai Kohsuke、Nonoyama Shigeaki、Morio Tomohiro
    • Journal Title

      Journal of Clinical Immunology

      Volume: 38 Issue: 3 Pages: 300-306

    • DOI

      10.1007/s10875-018-0497-8

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Heterozygous Mutations in OAS1 Cause Infantile-Onset Pulmonary Alveolar Proteinosis with Hypogammaglobulinemia.2018

    • Author(s)
      Cho K, Yamada M, Agematsu K, Kanegane H, Miyake N, Ueki M, Akimoto T, Kobayashi N, Ikemoto S, Tanino M, Fujita A, Hayasaka I, Miyamoto S, Tanaka-Kubota M, Nakata K, Shiina M, Ogata K, Minakami H, Matsumoto N, Ariga T.
    • Journal Title

      Am J Hum Genet

      Volume: 102 Issue: 3 Pages: 480-486

    • DOI

      10.1016/j.ajhg.2018.01.019

    • NAID

      120006502505

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epstein-Barr Virus (EBV)-induced B-cell Lymphoproliferative Disorder Mimicking the Recurrence of EBV-associated Hemophagocytic Lymphohistiocytosis2018

    • Author(s)
      Yatsushiro Yuki、Nishikawa Takuro、Saito Aki、Nakazawa Yozo、Imadome Ken-Ichi、Nakagawa Shunsuke、Kodama Yuichi、Okamoto Yasuhiro、Kanegane Hirokazu、Kawano Yoshifumi
    • Journal Title

      Journal of Pediatric Hematology and Oncology

      Volume: 0 Issue: 1 Pages: 1-1

    • DOI

      10.1097/mph.0000000000001075

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Haploinsufficiency of A20 causes autoinflammatory and autoimmune disorders.2018

    • Author(s)
      Kadowaki T, Ohnishi H, Kawamoto N, Hori T, Nishimura K, Kobayashi C, Shigemura T, Ogata S, Inoue Y, Kawai T, Hiejima E, Takagi M, Imai K, Nishikomori R, Ito S, Heike T, Ohara O, Morio T, Fukao T, Kanegane H.
    • Journal Title

      J Allergy Clin Immunol

      Volume: 141 Issue: 4 Pages: 1485-1488

    • DOI

      10.1016/j.jaci.2017.10.039

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term follow up of IPEX syndrome patients after different therapeutic strategies: an international multicenter retrospective study.2018

    • Author(s)
      Barzaghi F, Amaya Hernandez LC, Neven B, Ricci S, Kucuk ZY, Bleesing J, et al.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 141 Issue: 3 Pages: 1036-1049

    • DOI

      10.1016/j.jaci.2017.10.041

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hematopoietic stem cell transplantation for pulmonary alveolar proteinosis associated with primary immunodeficiency disease2018

    • Author(s)
      Tanaka-Kubota M, Shinozaki K, Miyamoto S, Yanagimachi M, Okano T, Mitsuiki N, Ueki M, Yamada M, Imai K, Takagi M, Agematsu K, Kanegane H, Morio T
    • Journal Title

      Int J Hematol

      Volume: 5 Issue: 5 Pages: 610-614

    • DOI

      10.1007/s12185-017-2375-1

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetic heterogeneity of uncharacterized childhood autoimmune diseases with lymphoproliferation.2018

    • Author(s)
      Takagi M, Hoshino A, Yoshida K, Ueno H, Imai K, Piao J, Kanegane H, Yamashita M, Okano T, Muramatsu H, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Hayashi Y, Kojima S, Morio T.
    • Journal Title

      Pediatr Blood Cancer.

      Volume: 65 Issue: 2

    • DOI

      10.1002/pbc.26831

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Flow cytometry-based diagnosis of primary immunodeficiency diseases2018

    • Author(s)
      Kanegane H, Hoshino A, Okano T, Yasumi T, Wada T, Takada H, Okada S, Yamashita M, Yeh TW, Nishikomori R, Takagi M, Imai K, Ochs HD, Morio T.
    • Journal Title

      Allergology International

      Volume: 67 Issue: 1 Pages: 43-54

    • DOI

      10.1016/j.alit.2017.06.003

    • NAID

      130006322088

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mechanisms of genotype-phenotype correlation in autosomal dominant anhidrotic ectodermal dysplasia with immune deficiency.2018

    • Author(s)
      Petersheim D, Massaad MJ, Lee S, Scarselli A, Cancrini C, Moriya K, Sasahara Y, Lankester AC, Dorsey M, Di Giovanni D, Bezrodnik L, Ohnishi H, Nishikomori R, Tanita K, Kanegane H, Morio T, Gelfand EW, Jain A, Secord E, Picard C, Casanova JL, Albert MH, Torgerson TR, Geha RS.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 141 Issue: 3 Pages: 1060-1073

    • DOI

      10.1016/j.jaci.2017.05.030

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of reduced-intensity conditioning and the risk of late-onset non-infectious pulmonary complications in pediatric patients.2017

    • Author(s)
      Nagasawa M, Mitsuiki N, Aoki Y, Ono T, Isoda T, Imai K, Takagi M, Kajiwara M, Kanegane H, Morio T.
    • Journal Title

      Eur J Haematol

      Volume: 99 Issue: 6 Pages: 525-531

    • DOI

      10.1111/ejh.12967

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Maternal T and B cell engraftment in two cases of X-linked severe combined immunodeficiency with IgG1 gammopathy.2017

    • Author(s)
      Okano T, Nishikawa T, Watanabe E, Watanabe T, Takashima T, Yeh TW, Yamashita M, Tanaka-Kubota M, Miyamoto S, Mitsuiki N, Takagi M, Kawano Y, Mochizuki Y, Imai K, Kanegane H, Morio T.
    • Journal Title

      Clin Immunol.

      Volume: 183 Pages: 112-120

    • DOI

      10.1016/j.clim.2017.08.003

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multicolor Flow Cytometry for the Diagnosis of Primary Immunodeficiency Diseases.2017

    • Author(s)
      Takashima T, Okamura M, Yeh TW, Okano T, Yamashita M, Tanaka K, Hoshino A, Mitsuiki N, Takagi M, Ishii E, Imai K, Kanegane H, Morio T.
    • Journal Title

      J Clin Immunol.

      Volume: 37 Issue: 5 Pages: 486-495

    • DOI

      10.1007/s10875-017-0405-7

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] HLA haploidentical hematopoietic cell transplantation using clofarabine and busulfan for refractory pediatric hematological malignancy2017

    • Author(s)
      Takagi M, Ishiwata Y, Aoki Y, Miyamoto S, Hoshino A, Matsumoto K, Nishimura A, Tanaka M, Yanagimachi M, Mitsuiki N, Imai K, Kanegane H, Kajiwara M, Takikawa K, Mae T, Tomita O, Fujimura J, Yasuhara M, Tomizawa D, Mizutani S, Morio T.
    • Journal Title

      Int J Hematol

      Volume: 105 Issue: 5 Pages: 686

    • DOI

      10.1007/s12185-017-2187-3

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Abnormal hematopoiesis and autoimmunity in human subjects with germline IKZF1 mutations.2017

    • Author(s)
      Hoshino A, Okada S, Yoshida K, Nishida N, Okuno Y, Ueno H, Yamashita M, Okano T, Tsumura M, Nishimura S, Sakata S, Kobayashi M, Nakamura H, Kamizono J, Mitsui-Sekinaka K, Ichimura T, Ohga S, Nakazawa Y, Takagi M, Imai K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Kojima S, Nonoyama S, Morio T, Kanegane H.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: - Issue: 1 Pages: 390-400

    • DOI

      10.1016/j.jaci.2016.09.029

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Haploinsufficiency of TNFAIP3 (A20) by germline mutation is involved in autoimmune lymphoproliferative syndrome.2017

    • Author(s)
      Takagi M, Ogata S, Ueno H, Yoshida K, Yeh T, Hoshino A, Piao J, Yamashita M, Nanya M, Okano T, Kajiwara M, Kanegane H, Muramatsu H, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Bando Y, Kato M, Hayashi Y, Miyano S, Imai K, Ogawa S, Kojima S, Morio T.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: - Issue: 6 Pages: 31286-6

    • DOI

      10.1016/j.jaci.2016.09.038

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant

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Published: 2017-04-28   Modified: 2021-02-19  

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