| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Chronic granulomatosis disease (CGD) is accompanied by granulomas and enteritis as well as susceptibility to infections due to reduction of reactive oxygen species (ROS) from phagocytes. We hypothesized that phagocytes without ROS production would cause abnormal immunity and compared the differences in inflammation-related expression in phagocytes caused by ROS production. However, no clear difference was found in this study. In the study of rare disorder caused impaired maturation of neutrophil, which is a type of phagocytes, clones with impaired maturation did not affect normal neutrophil differentiation. On the other hand, the research of particular kind of enteritis disease revealed the involvement of acquired immune abnormality in enteritis associated with granulomas. These findings suggest that abnormalities in acquired immunity caused by ROS may be involved in the pathology of CGD.
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