Role of Rab family small G proteins in the regulation of neuroblastoma microenvironment
Project/Area Number |
17K10110
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
|
Research Institution | Kobe University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
山本 暢之 神戸大学, 医学部附属病院, 特定助教 (20596043)
|
Project Period (FY) |
2017-04-01 – 2020-03-31
|
Project Status |
Completed (Fiscal Year 2019)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 神経芽腫細胞 / がん幹細胞 / 間葉系幹細胞 / 腫瘍随伴線維芽細胞 / Rab / 神経芽腫 |
Outline of Final Research Achievements |
High-risk neuroblastoma causes more than 50% relapse and shows therapy resistance. This is mainly due to tumor heterogeneity that is induced by tumor microenvironment and therapy stress and controlled by Rab family small G proteins (Rabs), key regulators of membrane traffic. In the present study, we have identified some members of Rabs, which potentially control the secretion of growth factors and tumor markers in neuroblastoma microenvironment.
|
Academic Significance and Societal Importance of the Research Achievements |
高リスク神経芽腫は、著しい治療抵抗性を示し、患者の半数以上が再発する代表的な小児がんである。がんの治療抵抗性獲得には、がん微小環境や治療ストレスによって誘導され、種々のサイトカインの分泌・取り込みを調節するRabファミリー低分子量G蛋白質(Rab)によって制御されるがんの多様性が重要だと考えられる。そこで本研究では、神経芽腫のがん微小環境におけるRab蛋白質の役割を明らかにすることを試みた。その成果は、神経芽腫の治療抵抗性獲得メカニズムを明らかにし、新たな治療法の開発、予後の改善に繋がると期待される。
|
Report
(4 results)
Research Products
(16 results)
-
-
-
-
[Journal Article] Involvement of WNT Signaling in the Regulation of Gestational Age-Dependent Umbilical Cord-Derived Mesenchymal Stem Cell Proliferation.2017
Author(s)
7: Iwatani S, Shono A, Yoshida M, Yamana K, Thwin KKM, Kuroda J, Kurokawa D, Koda T, Nishida K, Ikuta T, Fujioka K, Mizobuchi M, Taniguchi-Ikeda M, Morioka I, Iijima K, Nishimura N.
-
Journal Title
Stem Cells Int.
Volume: -
Pages: 1-16
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Gestational Age-Dependent Increase of Survival Motor Neuron Protein in Umbilical Cord-Derived Mesenchymal Stem Cells.2017
Author(s)
Iwatani S, Harahap NIF, Nurputra DK, Tairaku S, Shono A, Kurokawa D, Yamana K, Thwin KKM, Yoshida M, Mizobuchi M, Koda T, Fujioka K, Taniguchi-Ikeda M, Yamada H, Morioka I, Iijima K, Nishio H, Nishimura N.
-
Journal Title
Front Pediatr.
Volume: -
Pages: 194-194
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
[Presentation] Level of seven neuroblastoma-associated mRNAs analyzed by droplet digital PCR is correlated between bone marrow and peripheral blood in high-risk neuroblastoma.2019
Author(s)
Uemura S, Ishida T, Thwin KK, Lin KS, Yamamoto N, Tamura A, Kishimoto K, Mori T, Hasegawa D, Kosaka Y, Nino N, Takafuji S, Iijima K, Nishimura N.
Organizer
第61回日本小児血液・がん学会学術集会
Related Report
-
[Presentation] Elevated minimal residual disease marker expression in peripheral blood of three high-risk neuroblastoma cases.2018
Author(s)
Thwin KK, Ishida T, Uemura S, Yamamoto N, Tamura A, Kozaki A, Saito A, Kishimoto K, Hasegawa D, Kosaka Y, Nino N, Takafuji S, Mori T, Iijima K, Nishimura N.
Organizer
Advances in Neuroblastoma Research Conference 2018
Related Report
Int'l Joint Research
-
[Presentation] Expression profiles of seven minimal residual disease markers in bone marrow and peripheral blood of patients with high-risk neuroblastoma.2018
Author(s)
Thwin KK, Ishida T, Uemura S, Yamamoto N, Tamura A, Kozaki A, Saito A, Kishimoto K, Hasegawa D, Kosaka Y, Nino N, Takafuji S, Mori T, Iijima K, Nishimura N.
Organizer
The 50th Congress of the International Society of Pediatric Oncology
Related Report
Int'l Joint Research
-
-
-
[Presentation] Quantitation of minimal residual disease by droplet digital PCR in high-risk neuroblastoma patients.2018
Author(s)
Nishimura N, Ishida T, Thwin KK, Uemura S, Yamamoto N, Tamura A, Nino N, Kozaki A, Saito A, Kishimoto K, Hasegawa D, Kosaka Y, Takafuji S, Mori T, Iijima K.
Organizer
第60回日本小児血液・がん学会学術集会
Related Report
-
[Presentation] Involvement of DENND2A and Rab9B in the progression of neuroblastoma.2017
Author(s)
Yamamoto N, Thwin KK, Takafuji S, Uemura S, Nino N, Mori T, Ishida T, Hasegawa D, Kosaka Y, Iijima K, and Nishimura N.
Organizer
3rd Asia-Pacific International Symposium of Neuroblastoma
Related Report
Int'l Joint Research
-
[Presentation] 早産児の臍帯由来間葉系幹細胞の増殖におけるWNTシグナル経路の役割.2017
Author(s)
岩谷壮太, 庄野朱美, 山名啓司, Khin Kyae Mon Thwin, 黒川大輔, 西田浩輔, 西山将広, 藤岡一路, 生田寿彦, 吉田牧子, 溝渕雅巳, 森岡一朗, 飯島一誠, 西村範行.
Organizer
第16回日本再生医療学会総会
Related Report
-
[Presentation] ブレオマイシン誘発肺障害モデルラットにおける臍帯由来間葉系幹細胞の効果.2017
Author(s)
山名啓司, 岩谷壮太, 黒川大輔, Kyae Mon Thwin Khin, 西田浩輔, 西山将広, 藤岡一路, 庄野朱美, 生田寿彦, 吉田牧子, 溝渕雅巳, 森岡一朗, 飯島一誠, 西村範行.
Organizer
第16回日本再生医療学会総会
Related Report
-