Gut microbiota development of preterm infants hospitalised in intensive care units

• Project/Area Number: 17K10114
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Ehime University
• Principal Investigator: Tauchi Hisamichi 愛媛大学, 医学部附属病院, 准教授 (30314959)
• Co-Investigator(Kenkyū-buntansha): 石井 榮一 愛媛大学, 医学系研究科, 教授 (20176126) ; 越智 史博 愛媛大学, 医学部附属病院, 講師 (30637905) ; 江口 真理子 愛媛大学, 医学系研究科, 教授 (40420781)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 腸内細菌叢 / NICU / ビフィズス菌 / 新生児 / 腸内細菌

Outline of Final Research Achievements

We investigated morphosis of the intestinal bacterial flora in a premature infant (under gestational ages 37 weeks) and the healthy term infant (gestational ages 37-42 weeks) raised in a neonatal intensive care unit (NICU).(1) The premature infant raised in NICU is behind with the colonization of the bifidus bacillus as compared with a term infant.(2) As for the premature infant raised in NICU, there are many staphylococcal groups where a thing with some pathogenicity belongs to.
(3) When intestinal bacterial flora constitution of the bifidus bacillus superiority is formed, an enteral organic acid concentration increases, and pH decreases.

Academic Significance and Societal Importance of the Research Achievements

本試験の結果、NICUで保育される早産児では、腸内細菌叢の形成が健康な正期産児とは異なり、特にビフィズス菌優勢の腸内細菌叢の形成が遅れていることを確認した。これは、NICUで保育されている早産児は、衛生的に保たれた閉鎖環境にいるため、様々な菌と接触する機会が少ないことが、その要因の一つであると考えられる。
今回得られた知見は、NICUで保育された早産児における腸内細菌叢の形成の遅れを確認したものであり、出生後間もない時期からビフィズス菌を与えることにより正常な腸内細菌叢へ導くなど、新たな対応策を構築するための糸口となる可能性がある。

Research Products

• [Journal Article] Gut microbiota development of preterm infants hospitalised in intensive care units (2019)
  • Author(s): Tauchi H.、Yahagi K.、Yamauchi T.、Hara T.、Yamaoka R.、Tsukuda N.、Watanabe Y.、Tajima S.、Ochi F.、Iwata H.、Ohta M.、Ishii E.、Matsumoto S.、Matsuki T.
  • Journal Title: Beneficial Microbes Volume: 10 Issue: 6 Pages: 641-651
  • DOI: 10.3920/bm2019.0003
  • Peer Reviewed / Open Access
• [Journal Article] Association between daptomycin susceptibility and teicoplanin resistance in Staphylococcus epidermidis. (2019)
  • Author(s): Watanabe S, Kawakami Y, Kimura H, Murakami S, Miyamoto H, Takatori S, Suemori K, Tanaka M, Tanaka A, Tanaka K, Tauchi H, Maki J, Araki H, Yamaguchi T.
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 18533-18533
  • DOI: 10.1038/s41598-019-55149-z
  • Peer Reviewed / Open Access
• [Journal Article] Early detection of the PAX3-FOXO1 fusion gene in circulating tumor-derived DNA in a case of alveolar rhabdomyosarcoma (2019)
  • Author(s): Eguchi-Ishimae M, Tezuka M, Kokeguchi T, Nagai K, Moritani K, Yonezawa S, Tauchi H, Tokuda K, Ishida Y, Ishii E, Eguchi M
  • Journal Title: Genes Chromosomes Cancer Volume: 印刷中 Issue: 8 Pages: 521-529
  • DOI: 10.1002/gcc.22734
  • Peer Reviewed / Open Access
• [Journal Article] Mesenchymal Stem Cell Therapy Overcomes Steroid Resistance in Severe Gastrointestinal Acute Graft-Versus-Host Disease. (2019)
  • Author(s): Moritani K, Miyawaki R, Tokuda K, Ochi F, Eguchi-Ishimae M, Tauchi H, Eguchi M, Ishii E, Nagai K
  • Journal Title: Case Rep Transplant Volume: 2019 Pages: 1-5
  • DOI: 10.1155/2019/7890673
  • Peer Reviewed / Open Access
• [Journal Article] Gut microbiota development of preterm infants hospitalised in intensive care units (2019)
  • Author(s): H.Tauchi, K. Yahagi, T. Yamauchi, T. Hara, R. Yamaoka, N. Tsukuda, Y. Watakabe, S. Tajima, F. Ochi, H. Iwata, M. Ohta, E. Ishii, S. Matsumoto and T. Matsuki
  • Journal Title: Beneficial Microbes Volume: 印刷中
  • Peer Reviewed / Open Access
• [Journal Article] Therapeutic Effect of Linezolid in Children With Health Care-Associated Meningitis or Ventriculitis (2018)
  • Author(s): Ochi Fumihiro、Tauchi Hisamichi、Nagai Kozo、Moritani Kyoko、Tezuka Mari、Jogamoto Toshihiro、Aibara Kaori、Motoki Takahiro、Ishii Eiichi
  • Journal Title: Clinical Pediatrics Volume: 57 Issue: 14 Pages: 1672-1676
  • DOI: 10.1177/0009922818803399
  • Peer Reviewed
• [Journal Article] Sepsis and Pleural Empyema Caused by Streptococcus pyogenes after Influenza A Virus Infection (2018)
  • Author(s): Ochi Fumihiro、Tauchi Hisamichi、Jogamoto Toshihiro、Miura Hiromitsu、Moritani Tomozo、Nagai Kozo、Ishii Eiichi
  • Journal Title: Case Reports in Pediatrics Volume: 2018 Pages: 1-4
  • DOI: 10.1155/2018/4509847
  • Peer Reviewed / Open Access
• [Presentation] NICUで治療されている新生児の腸内細菌叢獲得過程における特徴 (2020)
  • Author(s): 田内久道、山内俊史、越智史博、太田雅明、岩田はるか、石井榮一、江口真理子
  • Organizer: 第123回日本小児科学会学術集会
• [Presentation] 渡航医学における乳酸菌の果たす役割 (2018)
  • Author(s): 田内久道
  • Organizer: 第22回 日本渡航医学会学術集会
  • Invited
• [Presentation] Infection control for pediatric patients with cancer. (2018)
  • Author(s): H Tauchi
  • Organizer: The 6th Matsuyama-Gwangju Pediatric Society Joint Meeting.
  • Int'l Joint Research / Invited
• [Presentation] 日常診療での感染対策 (2018)
  • Author(s): 田内久道
  • Organizer: 第70回中国四国小児科学会
  • Invited
• [Presentation] Incidence of Mycoplasma hominis in pregnant women in Japan, and susceptibility to antimicrobial agents. (2018)
  • Author(s): 1.Suemori K, Murakami S, Ochi F, Saito M, Tamaki M, Tao M, Uchikura Y, Miyamoto H, Sugiyama T, Tauchi H.
  • Organizer: The Asia Pacific Congress of Clinical Microbiology and Infection
  • Int'l Joint Research