| Project/Area Number |
17K10142
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Yamaguchi University |
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Principal Investigator |
MIZUTANI Makoto 山口大学, 大学院医学系研究科, 助教 (10593303)
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| Co-Investigator(Kenkyū-buntansha) |
松重 武志 山口大学, 医学部附属病院, 講師 (60528941)
長谷川 俊史 山口大学, 大学院医学系研究科, 教授 (90314806)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 小児腎臓 / 上部尿路感染症 / 高サイトカイン血症 / IFN-γ / 急性巣状細菌性腎炎 / インターフェロンγ / 腎瘢痕 / 小児 |
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| Outline of Final Research Achievements |
We have found that IFN-γ is greatly involved in the pathophysiology of acute focal bacterial nephritis (AFBN), especially the process of inflammation. Pathological analysis of “IFN-γ hyperproduction” in this study. Cytokine measurements showed that sTNFR1 as activation of macrophages was significantly higher in AFBN than in acute pyelonephritis (APN) (4,100 vs. 3,400 pg/mL, p=0.006). It is considered that macrophages are affected by IFN-γ. As a study of the source of IFN-γ production, we have performed a cytokine analysis of intracellular mononuclear cells in peripheral blood, but the identification of the producing cell has not been clarified.
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| Academic Significance and Societal Importance of the Research Achievements |
AFBNの病態解明を進めるべく、本研究を実施した。サイトカイン解析では, AFBN患児においてIFN-γの影響を受けると考えられるマクロファージの活性化を示唆する所見を得た。AFBNが高サイトカイン血症を来す病態が追加証明され, 上部尿路感染症の中で重症病態であることがより明確になった. IFN-γ産生源の検討では，明らかな産生細胞の同定には至らず, 新規治療法の確立とともに今後の研究課題となった．
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