Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Outline of Final Research Achievements |
We generated a mouse strain in which Keap1 gene is inactivated only in renal straight proximal tubules by conditional targeting using Cre loxP system, thus resulting in kidney specific local activation of Nrf2 which plays a central role for antioxidant protection mechanisms. Renal injury was introduced in this mouse strain to see weather renal injury was ameliorated by the kidney specific local Nrf2 activation. We were unable to demonstrate the alleviation of cyclosporine A-induced renal damage in this mouse strain. However, the renal damage induced by unilateral ureteral obstruction was alleviated in this mouse strain as shown by renal histology and renal damage-related gene expressions.
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