Clinicopathologic approach to pediatric membranous nephropathy associated with congenital anomaly of kidney and urinary tract and the antigenic target
Project/Area Number |
17K10158
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Tokyo Women's Medical University |
Principal Investigator |
Kaneko Naoto 東京女子医科大学, 医学部, 助教 (90791955)
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Co-Investigator(Kenkyū-buntansha) |
張田 豊 東京大学, 医学部附属病院, 准教授 (10451866)
服部 元史 東京女子医科大学, 医学部, 教授 (50192274)
神田 祥一郎 東京大学, 医学部附属病院, 助教 (60632651)
五島 直樹 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究チーム長 (70215482)
三浦 健一郎 東京女子医科大学, 医学部, 講師 (70408483)
秋岡 祐子 東京女子医科大学, 医学部, 非常勤講師 (90212422)
柴垣 芳夫 北里大学, 薬学部, 講師 (90235565)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 小児膜性腎症 / 先天性腎尿路異常 / 原因抗原 / 膜性腎症 / 小児 / プロテオミクス / 自己抗原 / 先天性腎尿路異常(CAKUT) / 自己反応性抗原 |
Outline of Final Research Achievements |
Membranous nephropathy (MN) is an autoimmune kidney disease and manifests histologically by subepithelial immune deposits at the glomerular basement membrane in the kidney containing IgGs. The discovery in the past decade of the antigens as the primary target in adult MN has dramatically altered both the diagnostic and therapeutic approach. However, those antigens have not been identified in pediatric MN. To identify major antigenic target in pediatric MN, we examined serum samples of children with MN associated with congenital anomalies of the kidney and urinary tract and those with idiopathic MN from multiple institutions. We performed comprehensive analysis using protein array analysis and identified novel candidates of antigen which is specific to pediatric MN.
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Academic Significance and Societal Importance of the Research Achievements |
小児の膜性腎症は大半が多量の蛋白尿を呈するネフローゼ症候群で発症するが、特異的な治療法はまだないのが現状である。成人に比べて腎予後は比較的良いとされているが、腎機能が低下した例の報告もある。 小児膜性腎症において特有の病因自己抗原を同定することにより、病態解明だけでなく正確な診断が可能となり、抗体価による病勢モニタリングや特異的な治療の開発につなげるといった意義を有する。
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Individualized concept for the treatment of autosomal recessive polycystic kidney disease with end-stage renal disease.2020
Author(s)
Miura K, Sato Y, Yabuuchi T, Kaneko N, Ishizuka K, Chikamoto H, Akioka Y, Nawashiro Y, Hisano M, Imamura H, Miyai T, Sakamoto S, Kasahara M, Fuchinoue S, Okumi M, Ishida H, Tanabe K, Hattori M.
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Journal Title
Pediatr Nephrol
Volume: Mar 3
Issue: 3
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Deletion in the cobalamin synthetase W domain-containing protein 1 gene is associated with congenital anomalies of the kidney and urinary tract.2020
Author(s)
Kanda S, Ohmuraya M, Akagawa H, Horita S, Yoshida Y, Kaneko N, Sugawara N, Ishizuka K, Miura K, Harita Y, Yamamoto T, Oka A, Araki K, Furukawa T, Hattori M.
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Journal Title
J Am Soc Nephrol
Volume: 31
Issue: 1
Pages: 139-147
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] 臨床・病理・遺伝学的解析に基づく腎移植後FSGS再発リスク評価2019
Author(s)
金子 直人,三浦 健一郎,飯田 貴也,谷口 洋平,長澤 武,伴 英樹,白井 陽子,高木 陽子,薮内 智朗,橋本 多恵子,石塚 喜世伸,張田 豊,服部 元史
Organizer
第122回日本小児科学会学術集会
Related Report
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[Presentation] Predicting the risk of recurrence of FSGS in pediatric kidney transplant recipients - A comprehensive approach -2019
Author(s)
Naoto Kaneko, Kenichiro Miura, Takaya Iida, Yohei Taniguchi, Hideki Ban, Takeshi Nagasawa, Yoko Shirai, Yoko Takagi, Tomoo Yabuuchi, Taeko Hashimoto, Kiyonobu Ishizuka, Hidenori Sato, Yutaka Harita, Toshiyuki Yamamoto, Yuko Akioka, Motoshi Hattori
Organizer
第54回日本小児腎臓病学会学術集会
Related Report
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[Presentation] Precise Clinicopathologic Findings may Increase the Detection Rate of Gene Mutations in Pediatric Kidney Transplant Recipients with Focal Segmental Glomerulosclerosis2019
Author(s)
Naoto Kaneko, Kenichiro Miura, Taro Ando, Takaya Iida, Atsutoshi Shiratori, Sho Ishiwa, Yoko Shirai, Tomoo Yabuuchi, Taeko Hashimoto, Kiyonobu Ishizuka, Hidenori Sato, Yutaka Harita, Motoshi Hattori
Organizer
Kidney Week 2019 - American Society of Nephrology
Related Report
Int'l Joint Research
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[Presentation] Infectious Complications in Pediatric Kidney Transplant Recipients Treated with Rituximab: A Single-center Study2018
Author(s)
Naoto Kaneko, Ken-ichiro Miura, Yohei Taniguchi, Takeshi Nagasawa, Ryutaro Hisatomi, Hideki Ban, Yoko Shirai, Tomoo Yabuuchi, Yoko Takagi, Kiyonobu Ishizuka, Hiroko Chikamoto, Yuko Akioka and Motoshi Hattori
Organizer
ISN Frontiers meetings
Related Report
Int'l Joint Research
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[Presentation] Prophylactic pretransplantation plasmapheresis combined with rituximab for pediatric recipients with primary focal segmental glomerulosclerosis to prevent post-transplant recurrence2017
Author(s)
Naoto Kaneko, Ken-ichiro Miura, Yuji Tomii, Keiichi Takizawa, Rumi Miyabe, Yohei Sasada, Tomoo Yabuuchi, Yasuyuki Sato, Taeko Hashimoto, Kiyonobu Ishizuka, Hiroko Chikamoto, Yuko Akioka, Motoshi Hattori
Organizer
11th International Society for Apheresis (ISFA) Congress
Related Report
Int'l Joint Research
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