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Basic research on preemptive medicine for early intervention using the low birth weight model

Research Project

Project/Area Number 17K10195
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionNippon Medical School

Principal Investigator

Nemoto Takahiro  日本医科大学, 医学部, 准教授 (40366654)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsDOHaD / 低出生体重 / 追いつき成長 / 低分子RNA / 成長障害 / 先制医療 / エピゲノム / 成長ホルモン / 生理学
Outline of Final Research Achievements

For normal growth, growth hormone (GH) acts on the GH receptor expressed in the liver, and body length increases through the secretion of insulin-like growth factor (IGF-1). Low birth weight rats from mother rats with low carbohydrate calorie restriction increased miR-322 expression in the liver, and miR-322 also reduced the production of GH receptor and IGF-1.
When these short rats are bred to produce the next generation of offspring, the offspring of this grandchild generation will have a lower birth weight even if the mother rat does not diet during pregnancy, and some will have a similar mechanism.

Academic Significance and Societal Importance of the Research Achievements

日本では低出生体重児の出生率が増加しています。ヒトの疫学調査を元に発達してきたDevelopmental Origins of Health and Disease (DOHaD) 学説によると、低出生体重児は非感染性の慢性疾患の発症リスクが高いと言われている。そして、増加するリスクを抱えた児に対して、早期診断と早期介入を目指した先制医療の実現が求められている。精緻化された早期診断・早期介入のためにmiR-322を標的とした検査法が開発できれば、miR-322で介入が必要か否かを選別し、miR-322の発現を抑制することで成長を促すことが可能になるかもしれない。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (8 results)

All 2020 2019 2018 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results) Remarks (1 results)

  • [Journal Article] Fetal malnutrition-induced catch up failure is caused by elevated levels of miR-322 in rats.2020

    • Author(s)
      Nemoto T, Kakinuma Y.
    • Journal Title

      Sci Rep.

      Volume: 10 Issue: 1 Pages: 1339-1339

    • DOI

      10.1038/s41598-020-58392-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of Noncoding RNAs in Stress-Related Neuropsychiatric Diseases Caused by DOHaD Theory2018

    • Author(s)
      Nemoto Takahiro、Kakinuma Yoshihiko
    • Journal Title

      Adv Exp Med Biol

      Volume: 1012 Pages: 49-59

    • DOI

      10.1007/978-981-10-5526-3_6

    • ISBN
      9789811055256, 9789811055263
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] DOHaD学説と神経内分泌2019

    • Author(s)
      根本崇宏
    • Organizer
      第46回 日本神経内分泌学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 健康体質を規定するホルモンミリュー2019

    • Author(s)
      根本 崇宏
    • Organizer
      日本プロテオーム学会2019年大会・第70回日本電気泳動学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Investigation of intervention effect on thrifty phenotype of low birth weight rats2019

    • Author(s)
      Takahiro Nemoto
    • Organizer
      ENDO2019 (annual meeting of America endocrine society)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Investigation of Intervention Effect on Thrifty Phenotype of Low Birth Weight Rat2019

    • Author(s)
      Nemoto T, Kakinuma Y
    • Organizer
      ENDO2019(アメリカ内分泌学会2019年年会)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of methyl donor supplementation on embryonic malnutrition-induced low birth weight rats2018

    • Author(s)
      Nemoto T, Kakinuma Y
    • Organizer
      Nutrition2018(アメリカ栄養学会2018年年会)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Remarks] 低出生体重児で成長が追いつかず低身長が生じる機序を解明

    • URL

      https://research-er.jp/articles/view/85675

    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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