| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In this study, the mechanism and factors involved in the development of hair follicles or sweat glands were explored by using an in-vitro model. This model induced the differentiation in hair follicles or sweat glands by forming condensed “epithelial-mesenchymal cell mass” or “spheroid”. The epidermal-mesenchymal cell mass derived from mouse dorsal skin showed differentiation into hair follicles, while the differentiation into sweat glands was not observed in the epidermal-mesenchymal cell mass/spheroid derived from mouse footpad skin. Constituent cells were preferably collected at the time of neonatal when epidermal buds started to grow, and the differentiation seemed independent of the number of mesenchymal cells involved. Regeneration of sweat glands may require a sufficient number of epithelial cells purified from epidermal buds, and may involve key growth factors in addition to epithelial-mesenchymal cell interactions.
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