| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Atopic dermatitis is a chronic inflammatory skin disease associated with impaired barrier function. In this study, we investigated the desiccation-associated inflammasome components and observed that the nucleotide-binding oligomerization domain-containing protein 2 (NOD2) may induce and the NOD-like receptor family pyrin domain containing 10 (NLRP10) may suppress inflammation. The activated NOD2 inflammasome triggers S100A9 protein synthesis, causes p38 and GATA3 phosphorylation, and promotes inflammation. These results suggest that the NOD2 inflammasome and its downstream effector S100A9 may play important roles in the pathogenesis of atopic dermatitis.
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