Roles of Notch signaling in regulating autophagy induction and stress response
| Project/Area Number |
17K10218
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kindai University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 創傷治癒 / Notchシグナル / 皮膚免疫 / 皮膚 / 乾癬 / ストレス応答 / アポトーシス / オートファジー / ストレス |
|---|
| Outline of Final Research Achievements |
In this study, we have found a new role of Hes1 in the skin wound healing. Skin epidermal-specific knockout of Hes1 resulted in the delayed wound healing through regulating the skin immunity and inflammation. In addition, we found that the Hes1 was involved in the development of proriasis.
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| Academic Significance and Societal Importance of the Research Achievements |
皮膚はからだの最表面に位置しているため、皮膚疾患は命を脅かすのみならず、見た目などの問題にも関わることから、QOLに大きな影響を与えることとなる。今回の研究成果により、Notchシグナルを制御することで褥瘡などの創傷治癒や乾癬などの治療に役立つことが期待される。さらに、皮膚免疫に関わるその他の疾患、例えばアトピー性皮膚炎や接触性皮膚炎などにも応用できる可能性を秘めている。
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Role of FBXW7 in the quiescence of gefitinib-resistant lung cancer stem cells in EGFR-mutant non-small cell lung cancer2019
Author(s)
Hidayat M, Mitsuishi Y, Takahashi F, Tajima K, Yae T, Miyahara K, Hayakawa D, Winardi W, Ihara H, Koinuma Y, Wirawan A, Nurwidya F, Kato M, Kobayashi I, Sasaki S, Takamochi K, Hayashi T, Suehara Y, Moriyama M, Moriyama H, Habu S, Takahashi K.
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Journal Title
Bosnian Journal of Basic Medical Sciences
Volume: 8;19(4)
Pages: 355-367
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Notch signaling enhances stemness by regulating metabolic pathways through modifying p53, NF-κB, and HIF-1α.2018
Author(s)
Moriyama H, Moriyama M, Ozawa T, Tsuruta D, Iguchi T, Tamada S, Nakatani T, Nakagawa K, Hayakawa T
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Journal Title
Stem Cells Dev
Volume: 印刷中
Issue: 13
Pages: 935-947
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Adipose-derived stromal/stem cells improve epidermal homeostasis2019
Author(s)
Hiroki Kiriyama, Mariko Moriyama, Shunya Sahara, Kaori Zaiki, Ayumi Ueno, Koichi Nakaoji, Kazuhiko Hamada, Toshiyuki Ozawa, Daisuke Tsuruta, Takao Hayakawa, Hiroyuki Moriyama
Organizer
44th Annual Meeting of the Japanese Society for Investigative Dermatology
Related Report
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