Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Outline of Final Research Achievements |
Atypical protein kinase Cλ (aPKCλ), a member of the protein kinase C family, regulates cell polarity. Two-step chemical carcinogenesis experiments in epidermis-specific aPKCλ-deficient mice revealed that aPKCλ can act positively or negatively on the development of squamous cell carcinoma, depending on the genetic background. On the other hand, in wound healing experiments, we have found that epidermis-specific aPKCλ-deficient mice showed delayed wound healing compared to control mice, and that aPKCλ regulates the direction of epidermal cell migration during wound healing.
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