Clarification of mechanism how environmental factors induce atopic dermatitis and exploring new treatments

• Project/Area Number: 17K10236
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Shinshu University
• Principal Investigator: Ogawa Eisaku 信州大学, 学術研究院医学系(医学部附属病院), 講師 (20451586)
• Co-Investigator(Kenkyū-buntansha): 木庭 幸子 信州大学, 学術研究院医学系, 准教授 (20436893) ; 奥山 隆平 信州大学, 学術研究院医学系, 教授 (80292332)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: アトピー性皮膚炎 / AhR

Outline of Final Research Achievements

We investigated the relationship between atopic dermatitis and air pollution, focusing on arylhydrocarbon receptor (AhR). So far, we have demonstrated that activation of AhR in keratinocytes activates nerve fibers via artemin. Here we show that AhR activation in keratinocytes increases IL33 and TSLP production and increases ILC2 in the skin, leading to inflammation.

Academic Significance and Societal Importance of the Research Achievements

アトピー性皮膚炎は非常に多くの患者がおり、経済的損失、患者QOL低下も著しい。近年、そのメカニズムの解明が非常に進んでおり、新たな治療法も生み出されている。私の研究成果は大気汚染との関係を主におき、新しいメカニズムを提起し、アトピー性皮膚炎の新たな治療法の開発に寄与できるのではないかと考える。

Research Products

• [Journal Article] Pediatric case of generalized pustular psoriasis developing acute pancreatitis (2018)
  • Author(s): Kobayashi Aya、Ogawa Eisaku、Matsuzaki Satoshi、Minagawa Akane、Okuyama Ryuhei
  • Journal Title: The Journal of Dermatology Volume: 45 Issue: 10
  • DOI: 10.1111/1346-8138.14315
  • Peer Reviewed
• [Journal Article] 乾癬の治療 生物学的製剤 TNF-α阻害薬とIL-12/23阻害薬 (2018)
  • Author(s): 小川英作、佐藤勇樹、奥山隆平
  • Journal Title: 日本臨床 Volume: 76 Pages: 128-134
• [Journal Article] 地域医療機関との連携を踏まえた乾癬の診療と生物学的製剤の活用 (2018)
  • Author(s): 小川英作、奥山隆平
  • Journal Title: Journal of Environmental Dermatology and Cutaneous Allergology Volume: 11 Pages: 289-295
  • NAID: 130006247169
• [Journal Article] Pathogenesis of psoriasis and development of treatment (2017)
  • Author(s): Ogawa Eisaku、Sato Yuki、Minagawa Akane、Okuyama Ryuhei
  • Journal Title: The Journal of Dermatology Volume: 45 Issue: 3 Pages: 264-272
  • DOI: 10.1111/1346-8138.14139
• [Journal Article] In vasculitis of small muscular arteries, activation of vessel-infiltrating CD8 T cells seems to be antigen-independent (2017)
  • Author(s): Kobayashi Mikiko、Ogawa Eisaku、Okuyama Ryuhei、Kanno Hiroyuki
  • Journal Title: Virchows Archiv Volume: 472 Issue: 2 Pages: 271-279
  • DOI: 10.1007/s00428-017-2264-2
  • Peer Reviewed
• [Journal Article] Epidemiological survey of patients with psoriasis in Matsumoto city, Nagano Prefecture, Japan (2017)
  • Author(s): Ogawa Eisaku、Okuyama Ryuhei、Seki Tomoko、Kobayashi Aya、Oiso Naoki、Muto Masahiko、Nakagawa Hidemi、Kawada Akira
  • Journal Title: The Journal of Dermatology Volume: 45 Issue: 3 Pages: 314-317
  • DOI: 10.1111/1346-8138.14101
  • Peer Reviewed
• [Presentation] 大気汚染物質による皮膚炎発症メカニズム (2019)
  • Author(s): 小川英作
  • Organizer: 第68回日本アレルギー学会学術大会
  • Invited
• [Presentation] 当科でバイオスイッチを行なった乾癬性関節炎患者について (2018)
  • Author(s): 小川英作、小林彩、関智子、代田志保、奥山隆平
  • Organizer: 第33回日本乾癬学会
• [Presentation] アダリムマブにて治療した慢性膿皮症を伴う乾癬性関節炎の１例 (2018)
  • Author(s): 小川英作、関智子、小林彩、奥山隆平
  • Organizer: 第33回日本乾癬学会