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The skin disease related joint symptoms and internal organ involvement

Research Project

Project/Area Number 17K10241
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionMie University

Principal Investigator

Yamanaka Keiichi  三重大学, 医学系研究科, 教授 (70314135)

Co-Investigator(Kenkyū-buntansha) 欠田 成人  三重大学, 医学系研究科, リサーチアソシエイト (00422866)
近藤 誠  三重大学, 医学部附属病院, 講師 (40464169)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords尋常性乾癬 / アトピー性皮膚炎 / 皮膚炎モデルマウス / サイトカイン / 心血管病変 / 脂質代謝異常 / 全身性アミロイドーシス / 皮膚炎 / 炎症性サイトカイン / Inflammatory skin march / 乾癬 / IL-1 / Inflammatory Skin March / 脳血管病変 / 関節炎 / アミロイドーシス / 皮膚炎症
Outline of Final Research Achievements

The prevalence of skin diseases such as psoriasis vulgaris and atopic dermatitis has been increasing and has become a social problem. Since skin is one of the largest immune organs, inflammatory cytokines produced from inflamed skin affect the internal organs. We used an original mouse model of spontaneous dermatitis to investigate the details of cerebrovascular lesions, arthritis, and amyloidosis induced by excessive production of IL-1 from lesions of skin inflammation. The involvement of IL-17 and the usefulness of anti-IL-17 antibody was also investigated.

Academic Significance and Societal Importance of the Research Achievements

アトピー性皮膚炎や尋常性乾癬等の患者は年々増加し、その内臓病変の生命予後への影響、関節炎の合併は注目を浴びており、本研究結果を社会に周知する効果は非常に大きく社会に貢献できる可能性が極めて高い。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (52 results)

All 2020 2019 2018 2017

All Journal Article (27 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 27 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (25 results) (of which Int'l Joint Research: 20 results,  Invited: 3 results)

  • [Journal Article] Consensus statements on pediatric atopic dermatitis from dermatology and pediatrics practitioners in Japan: Goals of treatment and topical therapy2020

    • Author(s)
      Arakawa Hirokazu、Shimojo Naoki、Katoh Norito、Hiraba Kazumi、Kawada Yasusuke、Yamanaka Keiichi、Igawa Ken、Murota Hiroyuki、Okafuji Ikuo、Fukuie Tatsuki、Nakahara Takeshi、Noguchi Taro、Kanakubo Akira、Katayama Ichiro
    • Journal Title

      Allergology International

      Volume: 69 Issue: 1 Pages: 84-90

    • DOI

      10.1016/j.alit.2019.08.006

    • NAID

      130007788686

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Vitamin D is no substitute for the sun.2019

    • Author(s)
      Matsushima Y, Mizutani K, Yamaguchi Y, Yamanaka K.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 143 Issue: 3 Pages: 929-931

    • DOI

      10.1016/j.jaci.2019.01.004

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interleukin-17-dressed neutrophil: Neutrophil does not produce but delivers interleukin-17 to lesional epidermis causing keratinocyte S100A expression.2019

    • Author(s)
      Mizutani K, Matsushima Y, Habe K, Yamanaka K.
    • Journal Title

      Indian J Dermatol Venereol Leprol.

      Volume: 85 Issue: 5 Pages: 531-534

    • DOI

      10.4103/ijdvl.ijdvl_375_18

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Psoriasiform Dermatitis Developing during Treatment of Juvenile Idiopathic Arthritis with Tocilizumab.2019

    • Author(s)
      Matsushima Y, Hayashi A, Mizutani K, Kondo M, Nakai Y, Habe K, Yamaguchi Y, Kozuka Y, Wakabayashi H, Yamanaka K.
    • Journal Title

      Case Rep Dermatol.

      Volume: 11 Issue: 3 Pages: 317-321

    • DOI

      10.1159/000504429

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pyoderma gangrenosum reproduced by an electric current flow.2019

    • Author(s)
      Ichikawa A, Kondo M, Yamanaka K
    • Journal Title

      Journal of Dermatology

      Volume: 46 Issue: 2 Pages: 64-66

    • DOI

      10.1111/1346-8138.14547

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated plasma D-dimer levels in dermatomyositis patients with cutaneous manifestations2019

    • Author(s)
      Habe K, Higashiyama A, Akeda T, Mori R, Kakeda M, Yamanaka K, Mizutani H
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 1410-1410

    • DOI

      10.1038/s41598-018-38108-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of subcutaneous tocilizumab in patients with rheumatoid arthritis and systemic sclerosis overlap syndrome: a report of two cases and review of the literature2019

    • Author(s)
      Wakabayashi H, Kino H, Kondo M, Yamanaka K, Hasegawa M, Sudo A
    • Journal Title

      BMC Rheumatology

      Volume: 24 Issue: 1 Pages: 15-15

    • DOI

      10.1186/s41927-019-0063-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An indirect comparison of long-term efficacy of every- 2-week dosing vs. recommended dosing of ixekizumab in patients who had static Physician’s Global Assessment>1 at week 122019

    • Author(s)
      Papp K, Maari C, Cauthen A, Gooderham M, Spelman L, Yamanaka K, Polzer P, Zhang L, Osuntokun O, Augustin M
    • Journal Title

      British Journal of Dermatology

      Volume: - Issue: 1 Pages: 52-59

    • DOI

      10.1111/bjd.18550

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mosquito Bite-Induced Localized NK/T-Cell Lymphoma Relapsed in a Patient With Complete Remission of Extranodal NK/T-Cell Lymphoma, Nasal Type2019

    • Author(s)
      Kondo M, Mizutani K, Yamanaka K
    • Journal Title

      Case Reports in Dermatology

      Volume: 11 Issue: 2 Pages: 194-197

    • DOI

      10.1159/000501358

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Infantile bullous pemphigoid successfully treated with i.v. immunoglobulin and cyclosporin2019

    • Author(s)
      Okada K, Kakeda M, Yamamoto S, Yokoyama T, Habe K, Nakato D, Hirayama M, Mizutani H, Yamanaka K
    • Journal Title

      The Journal of Dermatology

      Volume: 46 Issue: 6 Pages: 213-214

    • DOI

      10.1111/1346-8138.14726

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alopecia Diffusa while Using Interleukin-17 Inhibitors against Psoriasis Vulgaris2019

    • Author(s)
      Yajima M, Akeda T, Habe K, Yamanaka K
    • Journal Title

      Case Reports in Dermatology

      Volume: 11 Issue: 1 Pages: 82-85

    • DOI

      10.1159/000499030

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Stenosis of Cerebral Arteries and Impaired Brain Glucose Uptake by Long-Lasting Inflammatory Cytokine Release from Dermatitis Is Rescued by Anti-IL-1 Therapy.2018

    • Author(s)
      Kato S, Matsushima Y, Mizutani K, Kawakita F, Fujimoto M, Okada K, Kondo M, Habe K, Suzuki H, Mizutani H, Yamanaka K
    • Journal Title

      J Invest Dermatol.

      Volume: 10 Issue: 10 Pages: 2280-2283

    • DOI

      10.1016/j.jid.2018.04.016

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Case of Scedosporium aurantiacum infection detected in a subcutaneous abscess2018

    • Author(s)
      Kondo M,Goto H, Yamanaka K
    • Journal Title

      Medical Mycology Case Reports

      Volume: 20 Pages: 26-27

    • DOI

      10.1016/j.mmcr.2018.01.003

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison of positive ratio for red meat-specific immunoglobulin E between endemic and non-endemic area for Japanese spotted fever in Mie Prefecture, Japan.2018

    • Author(s)
      Kondo M, Goto H, Miyazaki M, Mori T, Yamanaka K.
    • Journal Title

      Journal of Dermatology

      Volume: 11 Issue: 11 Pages: 311-313

    • DOI

      10.1111/1346-8138.14354

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pyoderma gangrenosum reproduced by an electric current flow.2018

    • Author(s)
      Ichikawa A, Kondo M, Yamanaka K.
    • Journal Title

      J Dermatol.

      Volume: 46 Pages: 64-66

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Infantile bullous pemphigoid successfully treated with intravenous immunoglobulin and cyclosporine2018

    • Author(s)
      Okada K, Kakeda M, Yamamoto S, Yokoyama T, Habe K, Nakato D, Hirayama M, Mizutani H, Yamanaka K.
    • Journal Title

      J Dermatol.

      Volume: in press

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Interleukin-17-mediated manifestation of psoriasis and tinea.2018

    • Author(s)
      Imafuku S, Yamanaka K.
    • Journal Title

      Australas J Dermatol.

      Volume: in press Issue: 3

    • DOI

      10.1111/ajd.12780

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Plasma Levels of ADAMTS-13, von Willebrand Factor, VWFpp, and Fibrin-Related Markers in Patients With Systemic Sclerosis Having Thrombosis2017

    • Author(s)
      Habe K, Wada H, Higashiyama A, Akeda T, Tsuda K, Mori R, Kakeda M, Matsumoto T, Ohishi K, Yamanaka K, Katayama N, Mizutani H.
    • Journal Title

      Clin Appl Thromb Hemost

      Volume: 23 Issue: 6 Pages: 622-630

    • DOI

      10.1177/1076029617736382

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cutaneous polyarteritis nodosa causing refractory skin deformation and pigmentation as sequel.2017

    • Author(s)
      Okada K, Nakamori R, Mizutani H, Yamanaka K.
    • Journal Title

      An Bras Dermatol.

      Volume: 92 Issue: 5 suppl 1 Pages: 53-55

    • DOI

      10.1590/abd1806-4841.20175696

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Successful combination therapy of propranolol and prednisolone for a case with congenital Kasabach-Merritt syndrome.2017

    • Author(s)
      Mizutani K, Umaoka A, Tsuda K, Kakeda M, Habe K, Yamanaka K, Suyama M, Mizutani H.
    • Journal Title

      J Dermatol.

      Volume: 44 Issue: 12 Pages: 1389-1391

    • DOI

      10.1111/1346-8138.13984

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Skin inflammation leads immunoglobulin G aggregation and deposition in multiple organs2017

    • Author(s)
      Yamanaka K, Okada K, Nakanishi T, Mizutani K, Matsushima Y, Kondo M, Habe K, Mizutani H, Seo N
    • Journal Title

      J Dermatol Sci.

      Volume: 88 Issue: 1 Pages: 146-148

    • DOI

      10.1016/j.jdermsci.2017.05.013

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Case with acute urticaria by red meat after Haemaphysalis longicornis bite.2017

    • Author(s)
      Kondo M, Nakagawa T, Yamanaka K, Mizutani H
    • Journal Title

      J Dermatol.

      Volume: 44 Issue: 7

    • DOI

      10.1111/1346-8138.13865

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neutrophils are not the dominant interleukin-17 producer in psoriasis.2017

    • Author(s)
      Yamanaka, K., A. Yamagiwa, T. Akeda, M. Kondo, M. Kakeda, K. Habe, S. Imafuku, S. Sano and H. Mizutani
    • Journal Title

      J Dermatol

      Volume: 印刷中 Issue: 7 Pages: 170-171

    • DOI

      10.1111/1346-8138.13807

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Case with cellulitis, lymphangitis and subcutaneous nodule suspected due to Rickettsia japonica carrying tick bite.2017

    • Author(s)
      Kondo M, Akachi S, Yamazoe N, Yamanaka K, Mizutani H.
    • Journal Title

      J Dermatol.

      Volume: 44 Issue: 10 Pages: 1182-1183

    • DOI

      10.1111/1346-8138.13666

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Case of dengue fever missed at the initial screening of an endemic area but developed later in Japan2017

    • Author(s)
      Kondo M, Akachi S, Goto H, Umaoka A, Yamanaka K, Mizutani H.
    • Journal Title

      J Dermatol.

      Volume: 44 Issue: 7 Pages: 847-848

    • DOI

      10.1111/1346-8138.13562

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Restrictive interleukin-10 induction by an innocuous Parainfluenza virus vector ameliorates nasal allergy.2017

    • Author(s)
      Yamanaka K, Nakanishi T, Isono K, Hasegawa C, Inada Y, Mizutani K, Matsushima Y, Okada K, Mabuchi T, Kondo M, Yamagiwa A, Kakeda M, Habe K, Nosaka T, Gabazza EC, Yamazaki H, Mizutani H, Kawano M.
    • Journal Title

      J Allergy Clin Immunol

      Volume: 139 Issue: 2 Pages: 682-686

    • DOI

      10.1016/j.jaci.2016.05.044

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Well-controlled juvenile dermatomyositis over 20 years recurred after delivery.2017

    • Author(s)
      Okada K, Yamanaka K, Gyobu M, Ito Y, Mizutani H.
    • Journal Title

      J Dermatol.

      Volume: 44 Issue: 7 Pages: 855-857

    • DOI

      10.1111/1346-8138.13548

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Gastrointestinal amyloidosis by long-lasting inflammatory skin disease2019

    • Author(s)
      Mizutani K, Matsushima Y, Habe K, Yamanaka K, Okada K, and Kondo M
    • Organizer
      SID 77TH ANNUAL MEETING JOUNAL OF INVESTIGATIVE
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Melanoma cell survival is suppressed by splenocytes stimulated by Cutibacterium acnes2019

    • Author(s)
      Matsushima Y, Mizutani K, Okada K, Shirakami E, Umaoka A, Kondo M, Habe K, Yamanaka K
    • Organizer
      SID 77TH ANNUAL MEETING JOUNAL OF INVESTIGATIVE
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gut microbiome of the inflammatory skin model mouse2019

    • Author(s)
      Okada K, Yamanaka K, Matsushima Y, Mizutani K, Umaoka A
    • Organizer
      SID 77TH ANNUAL MEETING JOUNAL OF INVESTIGATIVE
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] THE CONCEPT OF INFLAMMATORY SKIN MARCH: IL-1-MEDIATED SKIN INFLAMMATION AND CEREBROVASCULAR AND CARDIOVASCULAR EVENTS2019

    • Author(s)
      Yamanaka K, Matsushima Y, Mizutani K, Okada K, Umaoka A, Rikiishi E, Kondo M, Habe K
    • Organizer
      24THWORLD CONGRESS OF DERMATOLOGY
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A CASE OF DIGITAL ULCER IN A PATIENT WITH SYSTEMIC SCLEROSIS AND ANTIPHOSPHOLIPID ANTIBODY SYNDROME2019

    • Author(s)
      Habe K, Matsumoto T, Nakajima A, Yamanaka K
    • Organizer
      24THWORLD CONGRESS OF DERMATOLOGY
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SIX CASES OF TSUTSUGAMUSHI DISEASE EXPERIENCED IN OUR DERMATOLOGY DEPARTMENT2019

    • Author(s)
      Umaoka A, Kondo M, Habe K, Yamanaka K
    • Organizer
      24THWORLD CONGRESS OF DERMATOLOGY
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PSORIASIS AND TINEA: INTERLEUKIN-17 MEDIATED MANIFESTATION2019

    • Author(s)
      Yamamoto S, Imafuku S, Yamanaka K
    • Organizer
      24THWORLD CONGRESS OF DERMATOLOGY
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The trigger factor of dermatomyositis with anti-MDA5 antibody may be enterovirus712019

    • Author(s)
      Kondo M, Kakeda M, Habe K, Yamanaka K
    • Organizer
      49TH ANNUAL ESDR MEETING
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Elevated plasma D-dimer levels in dermatomyositis patients with cutaneous manifestations2019

    • Author(s)
      Habe K, Wada H, Higashiyama A, Akeda T, Tsuda K, Mori R, Kakeda M, Mizutani H, Yamanaka K
    • Organizer
      The 45th Annual Meeting of Taiwanese Dermatological Association
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Splenocytes stimulated by Cutibacterium acnes suppress melanoma cell survival in vitro2019

    • Author(s)
      Matsushima Y, Mizutani K, Okada K, Umaoka A, Kondo M, Habe K, Yamanaka K
    • Organizer
      The 45th Annual Meeting of Taiwanese Dermatological Association
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A case of psoriatic erythroderma accompanied with multiple tophuses2019

    • Author(s)
      Sawada Y, Kondo M, Taniguchi T, Mizutani K, Nakai Y, Habe K, Yamanaka K
    • Organizer
      The 45th Annual Meeting of Taiwanese Dermatological Association
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IL-8 level in the bulla may be the useful diagnostic tool for overwhelming post-splenectomy infection2019

    • Author(s)
      Nakayama Y, Kondo M, Suzuki K, Habe K, Imai H, Yamanaka K
    • Organizer
      The 45th Annual Meeting of Taiwanese Dermatological Association
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Update on clinical data of biologics in psoriasis and treatment targets. Treat to target strategy will be discussed in relation to current clinical data2019

    • Author(s)
      Yamanaka K
    • Organizer
      Intermediate workshop on biologics for psoriasis Dermatological Society of Singapore
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Lecture-Tremfya Experience in Asia2019

    • Author(s)
      Yamanaka K
    • Organizer
      Tremfya experience in Japan
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Psoriasis is not only a skin disease: psoriasis and comorbidities in Asia2019

    • Author(s)
      Yamanaka K
    • Organizer
      Asia Psoriasis Working Group Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The stenosis of cerebral arteries and impaired brain glucose uptake by long-lasting inflammatory cytokine release from dermatitis, but rescued by anti-IL-1 therapy.2018

    • Author(s)
      Matsushima Y, Kato S, Mizutani K, Kawakita F, Okada K, Kondo M, Habe K, Suzuki H, Mizutani H, Yamanaka K.
    • Organizer
      International Investigative Dermatology
    • Related Report
      2018 Research-status Report
  • [Presentation] Hypoalbuminemia and inflammatory skin condition: long-lasting inflammatory cytokine release from dermatitis may be related.2018

    • Author(s)
      Kento Mizutani, Karin Okada, Yoshiaki Matsushima, Makoto Kondo, Masato Kakeda, Koji Habe, Keiichi Yamanaka
    • Organizer
      International Investigative Dermatology
    • Related Report
      2018 Research-status Report
  • [Presentation] HLA-B*1301-Positive two cases of salazosulfapyridine-induced drug induced hypersensitivity syndrome (DIHS)/ drug reaction with eosinophilia and systemic symptoms (DRESS).2018

    • Author(s)
      Kakeda M, Gyobu M, Tozawa T, Iida S, Goto H, Habe K, Yamanaka K.
    • Organizer
      EAACI DHM2018 Drug Hypersensitivity Meeting
    • Related Report
      2018 Research-status Report
  • [Presentation] The neutrophil does not produce but delivers IL-172018

    • Author(s)
      Mizutani K, Matsushima Y, Okada K, Umaoka A, Yamanaka K.
    • Organizer
      The 22nd Annual Meeting of The Korean Society for Psoriasis
    • Related Report
      2018 Research-status Report
  • [Presentation] The Cases of Psoriatic Arthritis with Spondyloarthritis; How Is the Prognosis?2018

    • Author(s)
      Umaoka A, Akeda T, Mizutani K, Matsushima Y, Okada K, Shirakami E, Yamanaka K
    • Organizer
      The 22nd Annual Meeting of The Korean Society for Psoriasis
    • Related Report
      2018 Research-status Report
  • [Presentation] Neutrophil is not the dominant IL-17 producer in psoriasis2017

    • Author(s)
      Yamanaka K, Yamagiwa A, Akeda T, Kondo M, Kakeda M, Habe K, Mizutani H
    • Organizer
      76th Annual Meeting of the Society for Investigative Dermatology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Rapid changes in the red meat and α-Gal specific IgE-RAST level in the clinical course of a case with red meat allergy and Haemaphysalis longicornis bite2017

    • Author(s)
      Kondo M, Nakagawa T, Yamanaka K, Mizutani H
    • Organizer
      76th Annual Meeting of the Society for Investigative Dermatology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Is the anti-NXP-2(ANTI-MJ) antibody a marker antibody for dysphagia in dermatomyositis?-report of three cases2017

    • Author(s)
      Kakeda M, Yamanaka K, Tsuda K, Matsushima Y, Gyobu M, Yokoyama T, Habe K, Muro Y, Mizutani H
    • Organizer
      The 26th European Academy of Dermatology and Venereology Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Skin inflammation leads immunoglobulin G aggregation and deposition in multiple organs2017

    • Author(s)
      Matsushima Y, Okada K, Mizutani K, Kondo M, Habe K, Yamanaka K
    • Organizer
      47th Annual ESDR Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Is neutrophil the dominant IL-17 producer in psoriasis?2017

    • Author(s)
      Mizutani K, Matsushima Y, Okada K, Yamagiwa A, Akeda T, Kondo M, Kakeda M, Habe K, Yamanaka K
    • Organizer
      47th Annual ESDR Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2022-12-28  

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