The skin disease related joint symptoms and internal organ involvement
| Project/Area Number |
17K10241
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Mie University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
欠田 成人 三重大学, 医学系研究科, リサーチアソシエイト (00422866)
近藤 誠 三重大学, 医学部附属病院, 講師 (40464169)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 尋常性乾癬 / アトピー性皮膚炎 / 皮膚炎モデルマウス / サイトカイン / 心血管病変 / 脂質代謝異常 / 全身性アミロイドーシス / 皮膚炎 / 炎症性サイトカイン / Inflammatory skin march / 乾癬 / IL-1 / Inflammatory Skin March / 脳血管病変 / 関節炎 / アミロイドーシス / 皮膚炎症 |
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| Outline of Final Research Achievements |
The prevalence of skin diseases such as psoriasis vulgaris and atopic dermatitis has been increasing and has become a social problem. Since skin is one of the largest immune organs, inflammatory cytokines produced from inflamed skin affect the internal organs. We used an original mouse model of spontaneous dermatitis to investigate the details of cerebrovascular lesions, arthritis, and amyloidosis induced by excessive production of IL-1 from lesions of skin inflammation. The involvement of IL-17 and the usefulness of anti-IL-17 antibody was also investigated.
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| Academic Significance and Societal Importance of the Research Achievements |
アトピー性皮膚炎や尋常性乾癬等の患者は年々増加し、その内臓病変の生命予後への影響、関節炎の合併は注目を浴びており、本研究結果を社会に周知する効果は非常に大きく社会に貢献できる可能性が極めて高い。
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] The Stenosis of Cerebral Arteries and Impaired Brain Glucose Uptake by Long-Lasting Inflammatory Cytokine Release from Dermatitis Is Rescued by Anti-IL-1 Therapy.2018
Author(s)
Kato S, Matsushima Y, Mizutani K, Kawakita F, Fujimoto M, Okada K, Kondo M, Habe K, Suzuki H, Mizutani H, Yamanaka K
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Journal Title
J Invest Dermatol.
Volume: 10
Issue: 10
Pages: 2280-2283
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] The Plasma Levels of ADAMTS-13, von Willebrand Factor, VWFpp, and Fibrin-Related Markers in Patients With Systemic Sclerosis Having Thrombosis2017
Author(s)
Habe K, Wada H, Higashiyama A, Akeda T, Tsuda K, Mori R, Kakeda M, Matsumoto T, Ohishi K, Yamanaka K, Katayama N, Mizutani H.
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Journal Title
Clin Appl Thromb Hemost
Volume: 23
Issue: 6
Pages: 622-630
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Restrictive interleukin-10 induction by an innocuous Parainfluenza virus vector ameliorates nasal allergy.2017
Author(s)
Yamanaka K, Nakanishi T, Isono K, Hasegawa C, Inada Y, Mizutani K, Matsushima Y, Okada K, Mabuchi T, Kondo M, Yamagiwa A, Kakeda M, Habe K, Nosaka T, Gabazza EC, Yamazaki H, Mizutani H, Kawano M.
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Journal Title
J Allergy Clin Immunol
Volume: 139
Issue: 2
Pages: 682-686
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] The stenosis of cerebral arteries and impaired brain glucose uptake by long-lasting inflammatory cytokine release from dermatitis, but rescued by anti-IL-1 therapy.2018
Author(s)
Matsushima Y, Kato S, Mizutani K, Kawakita F, Okada K, Kondo M, Habe K, Suzuki H, Mizutani H, Yamanaka K.
Organizer
International Investigative Dermatology
Related Report
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