Pathological involvement of the neuroimmune cycle in skin allergic diseases

Research Project

Project/Area Number	17K10242
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Dermatology
Research Institution	Kyoto University
Principal Investigator	Otsuka Atsushi 京都大学, 医学研究科, 特定准教授 (60582054)
Project Period (FY)	2017-04-01 – 2020-03-31
Project Status	Completed (Fiscal Year 2019)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	皮膚アレルギー疾患 / 末梢神経 / 神経ペプチド / 樹状細胞 / 免疫 / 神経
Outline of Final Research Achievements	It is widely known that itching of the skin is mediated by the peripheral nerves. However, recent studies have shown that peripheral nerves interact with immune cells and may be involved in the pathogenesis of skin allergic diseases. In this research question, we investigated the role of peripheral nerves in cutaneous allergic diseases. The results showed that neuropeptides released from peripheral nerves are involved in contact dermatitis. Translated with www.DeepL.com/Translator (free version)
Academic Significance and Societal Importance of the Research Achievements	皮膚アレルギー疾患における末梢神経の関与を明らかにした。本研究結果により、難治性の皮膚アレルギー疾患では神経ペプチドを標的とした新規治療法の開発が期待される。また、これまで知られていなかった末梢神経の働きを皮膚アレルギー疾患で明らかにしたことに学術的意義がある。