| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
The purpose of this study is to clarify the function of IER5 and the role of the IER5-HSF1 pathway in melanoma, a type of skin cancer with a poor prognosis. Re-analyse of the TCGA database revealed a poor prognosis in the IER5 high expression group, especially in the group of malignant melanoma patients with BRAF mutations. The evaluation of lung metastasis of IER5KO strain using mouse melanoma cell line B16F10 suggested that IER5 may have an important role in cancer metastasis. In addition, it was revealed that the IER5 protein has one-bipartile type Nuclear localization signal.
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