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Exploring clinical indicators to determine fitness to drive in patients with bipolar disorder

Research Project

Project/Area Number 17K10272
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionNagoya University

Principal Investigator

Iwamoto Kunihiro  名古屋大学, 医学系研究科, 准教授 (50569796)

Project Period (FY) 2017-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords双極性障害 / 運転技能 / 認知機能 / 向精神薬 / 運転適性判断 / 運転適性 / 精神薬理学 / 産業精神保健学
Outline of Final Research Achievements

The aim of this study was to examine the actual driving performance of patients with bipolar disorder and to identify factors that influence driving performance in order to extract clinical indicators that can be evaluated in a clinical setting to determine driving fitness. Driving simulator tasks, cognitive function tasks, symptom rating scales, prescribed medications, and driving behavior were investigated in 58 patients with stable bipolar disorder and 80 healthy controls. The results suggest that the patients' driving performance was not uniformly impaired, but that their attention function, number of mood episodes, and duration of illness were the clinical characteristics of interest in judging their fitness to drive.

Academic Significance and Societal Importance of the Research Achievements

本研究は、双極性障害患者の運転適性を判断するための有用な臨床指標が抽出し,双極性障害の運転技能に関する証左が圧倒的に不足する中で、世界的にも医療者の運転適性判断を補助する有用な情報を提供した。また,向精神薬よりも双極性障害患者の病状の方が運転能力に与える影響は大きい可能性が示唆され,服薬中の運転を一律に禁止する日本の双極性障害治療薬の添付文書は議論の余地があると考えられ、患者,家族,医療者および公共の誰もが納得できる安全で安心な車社会の実現にも寄与し、患者の社会参画を促進する社会的意義も有する。

Report

(7 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (57 results)

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article (32 results) (of which Peer Reviewed: 15 results,  Open Access: 7 results) Presentation (23 results) (of which Int'l Joint Research: 2 results,  Invited: 19 results) Book (2 results)

  • [Journal Article] Driving performance of patients with epilepsy undergoing antiepileptic monotherapy2023

    • Author(s)
      Iwamoto, K., Saji, M., Matsuoka, E, Kanemoto, K
    • Journal Title

      Psychiatry Clin. Neurosci. Rep

      Volume: 2 Issue: 1

    • DOI

      10.1002/pcn5.83

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The new guideline for evaluating effects of psychotropic drugs on the performance to drive a motor vehicle in Japan: Comparison with US FDA guideline2023

    • Author(s)
      Iwamoto K, Nakabayashi T, Yamaguchi A, Konishi Y, Saji M, Yoshimura R, Kanemoto K, Aoki H, Ando M, Ozaki N
    • Journal Title

      Neuropsychopharmacol Rep

      Volume: - Issue: 2 Pages: 172-176

    • DOI

      10.1002/npr2.12339

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 自動車運転を考慮した抗うつ薬の使い方2023

    • Author(s)
      岩本邦弘
    • Journal Title

      月刊薬事

      Volume: 65 Pages: 79-82

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Sensory evaluation of the bitterness of asenapine using D-sorbitol pretreatment: single-blind, placebo-controlled, crossover trial2023

    • Author(s)
      Wada S, Iwamoto K, Okumura H, Hida H, Hiraoka S, Kamei A, Mori D, Yamada K, Ozaki N
    • Journal Title

      BMC Psychiatry

      Volume: 23 Issue: 1 Pages: 159-159

    • DOI

      10.1186/s12888-023-04664-5

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Driving performance of euthymic outpatients with bipolar disorder undergoing real-world pharmacotherapy2022

    • Author(s)
      Yamaguchi A, Iwamoto K, Ando M, Fujita K, Yokoyama M, Akiyama T, Igarashi Y, Ozaki N.
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 76 Issue: 5 Pages: 172-178

    • DOI

      10.1111/pcn.13332

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Study of Factors Causing Sleep State Misperception in Patients with Depression2022

    • Author(s)
      Kawai Keita、Iwamoto Kunihiro、Miyata Seiko、Okada Ippei、Ando Motoo、Fujishiro Hiroshige、Noda Akiko、Ozaki Norio
    • Journal Title

      Nature and Science of Sleep

      Volume: Volume 14 Pages: 1273-1283

    • DOI

      10.2147/nss.s366774

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevalence of obstructive sleep apnea as assessed by polysomnography in psychiatric patients with sleep-related problems2022

    • Author(s)
      Okada Ippei、Miyata Seiko、Iwamoto Kunihiro、Fujishiro Hiroshige、Noda Akiko、Ozaki Norio
    • Journal Title

      Sleep and Breathing

      Volume: 26 Issue: 4 Pages: 1983-1991

    • DOI

      10.1007/s11325-022-02566-6

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Residual effects of zopiclone on driving performance using a standardized driving simulator among healthy volunteers2022

    • Author(s)
      Iwamoto K, Iwata M, Kambe D, Imadera Y, Tachibana N, Kajiyama Y, Ando M, Ozaki N
    • Journal Title

      Psychopharmacology (Berl)

      Volume: 239 Issue: 3 Pages: 841-850

    • DOI

      10.1007/s00213-022-06075-y

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 精神疾患患者における自動車運転技能-認知機能に着目して-2021

    • Author(s)
      岩田麻里, 岩本邦弘, 尾崎紀夫
    • Journal Title

      臨床精神医学

      Volume: 50 Pages: 1387-1393

    • Related Report
      2021 Research-status Report
  • [Journal Article] mpact of antiepileptic drugs on simulated driving in patients with epilepsy2021

    • Author(s)
      Saji M, Kanemoto K, Matsuoka E, Iwamoto K
    • Journal Title

      Seizure

      Volume: 92 Pages: 195-199

    • DOI

      10.1016/j.seizure.2021.09.003

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Validity and reliability of a driving simulator for evaluating the influence of medicinal drugs on driving performance2021

    • Author(s)
      Iwata M, Iwamoto K, Kitajima I, Nogi T, Onishi K, Kajiyama Y, Nishino I, Ando M, Ozaki N
    • Journal Title

      Psychopharmacology (Berl)

      Volume: 238 Issue: 3 Pages: 775-786

    • DOI

      10.1007/s00213-020-05730-6

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] ベンゾジアゼピン受容体作動薬と自動車運転2020

    • Author(s)
      岩本邦弘、岩田麻里、尾崎紀夫
    • Journal Title

      精神医学

      Volume: 62 Pages: 401-407

    • Related Report
      2020 Research-status Report
  • [Journal Article] 向精神薬と自動車運転試験 運転技能評価手法と証左から導かれる注意点2020

    • Author(s)
      山口亞希子、岩本邦弘、尾崎紀夫
    • Journal Title

      精神科治療学

      Volume: 35 Pages: 457-462

    • Related Report
      2020 Research-status Report
  • [Journal Article] 高齢者の不眠、過眠、薬物療法が運転に及ぼす影響と指導法を教えてください2020

    • Author(s)
      宮田聖子、岩本邦弘、尾崎紀夫
    • Journal Title

      Geriatric Medicine

      Volume: 58 Pages: 433-436

    • Related Report
      2020 Research-status Report
  • [Journal Article] 服薬中の精神疾患患者の運転支援2020

    • Author(s)
      尾崎紀夫、岩本邦弘
    • Journal Title

      学術の動向

      Volume: 25 Pages: 43-47

    • NAID

      130007907381

    • Related Report
      2020 Research-status Report
  • [Journal Article] 睡眠薬の服用患者と自動車運転 事故リスク低減のための指導箋2020

    • Author(s)
      岩本邦弘、岩田麻里、尾崎紀夫
    • Journal Title

      睡眠医療

      Volume: 14 Pages: 199-203

    • Related Report
      2020 Research-status Report
  • [Journal Article] Development and validation of a driving simulator for evaluating the residual effects of drugs on driving performance ? sensitivity analysis using zopiclone as a positive control2020

    • Author(s)
      Iwata M、Iwamoto K、Kambe D、Tachibana N、Ando M、Ozaki N
    • Journal Title

      Medicine

      Volume: 99 Issue: 12 Pages: e19395-e19395

    • DOI

      10.1097/md.0000000000019395

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 向精神薬と精神疾患が自動車運転に与える影響2019

    • Author(s)
      岩本邦弘
    • Journal Title

      ストレス科学

      Volume: 33 Pages: 249-258

    • Related Report
      2019 Research-status Report
  • [Journal Article] 精神疾患における睡眠障害治療の臨床的意義2019

    • Author(s)
      岩本邦弘
    • Journal Title

      日本精神薬学会誌

      Volume: 2 Pages: 48-49

    • Related Report
      2019 Research-status Report
  • [Journal Article] Protocol for the development and validation of a driving simulator for evaluating the influence of drugs on driving performance2019

    • Author(s)
      Iwata M, Iwamoto K, Omura T, Ando M, Ozaki N
    • Journal Title

      Medicine (Baltimore)

      Volume: 98 Issue: 8 Pages: e14613-e14613

    • DOI

      10.1097/md.0000000000014613

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 医薬品の日常生活機能への影響ー自動車運転技能を中心にー2018

    • Author(s)
      岩田麻里,岩本邦弘,河野直子,尾崎紀夫
    • Journal Title

      精神科治療学

      Volume: 33 Pages: 535-540

    • Related Report
      2018 Research-status Report
  • [Journal Article] Driving performance of stable outpatients with depression undergoing real-world treatment.2018

    • Author(s)
      Miyata, A., Iwamoto, K., Kawano, N., Aleksic, B., Ando, M., Ebe, K., Fujita, K., Yokoyama, M., Akiyama, T., Igarashi, Y., & Ozaki, N.
    • Journal Title

      Psychiatry and Clinical Neurosciences.

      Volume: - Issue: 6 Pages: 1-10

    • DOI

      10.1111/pcn.12648

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 統合失調症と自動車運転関連法規2018

    • Author(s)
      岩田麻里,岩本邦弘,河野直子,尾崎紀夫
    • Journal Title

      最新医学

      Volume: 別冊 1 Pages: 190-196

    • Related Report
      2018 Research-status Report
  • [Journal Article] 向精神薬と自動車運転 勤労者で注意すべきこと2018

    • Author(s)
      宮田明美,岩本邦弘,河野直子,尾崎紀夫
    • Journal Title

      臨床精神薬理

      Volume: 21 Pages: 1371-1377

    • Related Report
      2018 Research-status Report
  • [Journal Article] Evaluation method regarding the effect of psychotropic drugs on driving performance: A literature review2018

    • Author(s)
      Iwata M, Iwamoto K, Kawano N, Kawaue T, Ozaki N
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 72 Issue: 10 Pages: 747-773

    • DOI

      10.1111/pcn.12734

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of hypnotics on prefrontal cortex activity during a verbal fluency task in healthy male subjects: A near-infared spectroscopy study.2018

    • Author(s)
      Tsuruta Y, Iwamoto K, Banno M, Kawano N, Kohmura K, Miyata S, Fujishiro H, Noda Y, Noda A, Iritani S, Ozaki N.
    • Journal Title

      Hum Psychopharmacol

      Volume: 33 Issue: 6

    • DOI

      10.1002/hup.2678

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 抗精神病薬を服用している統合失調症の患者さんや抗うつ薬を服用しているうつ病の患者さんから自動車運転をしてもよいかと尋ねられました。どう答えたらよいでしょうか?2018

    • Author(s)
      岩田麻里,岩本邦弘,尾崎紀夫
    • Journal Title

      精神科治療学

      Volume: 33巻増刊 Pages: 236-237

    • Related Report
      2018 Research-status Report
  • [Journal Article] うつ病と運転能力2018

    • Author(s)
      岩本邦弘、河野直子、尾崎紀夫
    • Journal Title

      国際交通安全学会誌

      Volume: 17 Pages: 61-69

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] うつ病患者の自動車運転-運転の可否をどう判断するか-2017

    • Author(s)
      岩田麻里、岩本邦弘、河野直子、尾崎紀夫
    • Journal Title

      Progress in Medicine

      Volume: 37 Pages: 1425-1430

    • Related Report
      2017 Research-status Report
  • [Journal Article] 精神障害と自動車運転―わかっていることとは何か?2017

    • Author(s)
      岩本邦弘
    • Journal Title

      精神神経誌

      Volume: 119 Pages: 485-492

    • Related Report
      2017 Research-status Report
  • [Journal Article] 自動車運転と薬物問題-向精神薬2017

    • Author(s)
      岩本邦弘、尾崎紀夫
    • Journal Title

      Modern Physician

      Volume: 30 Pages: 346-352

    • Related Report
      2017 Research-status Report
  • [Journal Article] 気分障害を持つ人のための「自動車運転に関する心理教育」を考える2017

    • Author(s)
      木村卓、岩本邦弘、河野直子、尾崎紀夫
    • Journal Title

      精神医学

      Volume: 59 Pages: 301-309

    • Related Report
      2017 Research-status Report
  • [Presentation] 自動車運転における向精神薬の影響を評価するための新規運転評価系2022

    • Author(s)
      岩本邦弘,岩田麻里,尾崎紀夫
    • Organizer
      第118回日本精神神経学会学術総会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 医薬品が自動車運転技能に与える影響を評価するための新規運転評価系の開発2022

    • Author(s)
      岩田麻里, 岩本邦弘, 神辺太樹, 梶山優, 尾崎紀夫
    • Organizer
      BPCNPNPPP4学会合同年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] メンタルヘルスにおける服薬と自動車運転について留意すべきこと2022

    • Author(s)
      岩本邦弘
    • Organizer
      第29回日本産業ストレス学会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 薬物療法中の精神疾患患者における運転適性判断―証左から見えてくるもの2021

    • Author(s)
      岩本邦弘
    • Organizer
      第117回日本精神神経学会学術総会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] うつ病と自動車運転:社会機能を考慮した薬物療法とは?2021

    • Author(s)
      岩本邦弘
    • Organizer
      第54回日本てんかん学会学術集会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 服薬する精神疾患患者の自動車運転技能 処方医が注意すべきこと2021

    • Author(s)
      岩本邦弘
    • Organizer
      第31回日本臨床精神神経薬理学会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 気分障害治療薬と自動車運転2021

    • Author(s)
      岩本邦弘
    • Organizer
      第28回産業精神保健学会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 双極性障害患者における自動車運転技能評価2021

    • Author(s)
      山口亞希子,岩本邦弘,藤田潔,横山大範,秋山剛,五十嵐良雄,尾崎紀夫
    • Organizer
      日本うつ病学会-オンライン学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 向精神薬を服薬する精神疾患患者の自動車運転-証左に基づいて処方医が注意すべきこと2020

    • Author(s)
      岩本邦弘
    • Organizer
      第116回日本精神神経学会学術総会-オンライン学術総会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 向精神薬が自動車運転に及ぼす影響-自動車運転試験の現状-2019

    • Author(s)
      岩本邦弘
    • Organizer
      第115回日本精神神経学会学術総会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 偶発的RWAを呈する精神疾患の臨床的特徴2019

    • Author(s)
      岩本邦弘、藤城弘樹、宮田聖子、野田明子、尾崎紀夫
    • Organizer
      日本睡眠学会第44回定期学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 自動車運転に関する産業精神薬理学2019

    • Author(s)
      岩本邦弘
    • Organizer
      第29回日本臨床精神神経薬理学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 睡眠薬が認知機能・運転技能に与える影響2019

    • Author(s)
      岩本邦弘、宮田聖子、野田明子、尾崎紀夫
    • Organizer
      第9回日本認知症予防学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Driving performance of outpatients with bipolar disorder undergoing real-world pharmacotherapy2019

    • Author(s)
      Iwamoto K, Yamaguchi A, Ando M, Fujita K, Yokoyama M, Akiyama T, Igarashi Y, Yoshimura R, Ozaki N
    • Organizer
      6th Congress of Asian College of Neuropsychopharmacology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 向精神薬が自動車運転に及ぼす影響:エビデンスから分かること2018

    • Author(s)
      岩本邦弘
    • Organizer
      第114回日本精神神経学会学術総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Psychotropic and automobile driving2018

    • Author(s)
      Kunihiro Iwamoto
    • Organizer
      WFSBP Asia Pacific Regional Congress of Biological Psychiatry
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 精神疾患における睡眠障害治療の臨床的意義2018

    • Author(s)
      岩本邦弘
    • Organizer
      第2回日本精神薬学会総会・学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 向精神薬と精神疾患が自動車運転に与える影響2018

    • Author(s)
      岩本邦弘
    • Organizer
      第34回日本ストレス学会学術総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 向精神薬が運転技能に与える影響2017

    • Author(s)
      岩本邦弘
    • Organizer
      第27回日本臨床精神神経薬理学会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 高齢者うつ症状に対するアリピプラゾール増強療法の有効性・忍容性が変化した一例 :レビー小体病の治療経験から2017

    • Author(s)
      岩本邦弘、藤城弘樹、尾崎紀夫
    • Organizer
      第27回日本臨床精神神経薬理学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 精神疾患と向精神薬が自動車運転に及ぼす影響:これまでに得られている知見2017

    • Author(s)
      岩本邦弘
    • Organizer
      第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 若年者における不眠・うつ病の治療と社会的問題2017

    • Author(s)
      岩本邦弘
    • Organizer
      第42回日本睡眠学会学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 精神障害と自動車運転:証左に基づいた運転適性判断とは何か?2017

    • Author(s)
      岩本邦弘
    • Organizer
      第16回交通における安全と産業衛生の研究会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] 向精神薬と運転 In 高齢社会における人と自動車2021

    • Author(s)
      岩本邦弘、尾崎紀夫
    • Publisher
      コロナ社
    • Related Report
      2020 Research-status Report
  • [Book] 第4章 健康状態と運転、第5章 薬物と運転 In高齢者のモビリティ 運転可否判断から移動支援まで2020

    • Author(s)
      岩本邦弘
    • Publisher
      京都大学学術出版
    • Related Report
      2020 Research-status Report

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Published: 2017-04-28   Modified: 2024-01-30  

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