Involvement of anti-NMDA receptor antibody in psychiatric disorders and its clinical significance
Project/Area Number |
17K10288
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Akita University |
Principal Investigator |
TSUTSUI KO 秋田大学, 医学部附属病院, 講師 (40569604)
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Project Period (FY) |
2017-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 自己免疫性脳炎 / 抗NMDAR脳炎 / 緊張病 / 脳器質性精神障害 / 自己免疫性脳症 / 悪性緊張病 / 致死性緊張病 / 脳器質性障害 / 抗NMDA受容体脳炎 / 器質性障害 / 臨床 / 脳・神経 / 脳神経疾患 |
Outline of Final Research Achievements |
In recent years, it has been found that cases of autoimmune encephalitis, which is a neurological disease, are mixed among those diagnosed with psychiatric diseases such as malignant catatonia and lethal catatonia. From this, it was found that there are cases in which a certain number of autoantibodies are positive and the diagnosis is changed to autoimmune encephalitis by examining the cerebrospinal fluid and serum of cases diagnosed with schizophrenia and bipolar disorder. After the diagnosis was changed, the symptoms may be improved by immunotherapy and it was judged that it would bring benefits to the relevant cases.
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Academic Significance and Societal Importance of the Research Achievements |
精神科領域のケースと判断されていたものが、脳神経内科疾患であると診断変更になることで、根本的な治療内容の変更が行われこれにより寛解を得られうる場合がある。
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Report
(5 results)
Research Products
(18 results)
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[Journal Article] Anti-NMDA-receptor antibody in initial diagnosis of mood disorder.2019
Author(s)
Kawai H, Takaki M, Sakamoto S, Shibata T, Tsuchida A, Yoshimura B, Yada Y, Matsumoto N, Sato K, Abe K, Okahisa Y, Kishi Y, Takao S, Tsutsui K, Kanbayashi T, Tanaka K, Yamada N.
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Journal Title
Eur Neuropsychopharmacol.
Volume: 29(9)
Issue: 9
Pages: 1041-1050
DOI
Related Report
Peer Reviewed
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