| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Pair bonding between socio-sexual partners gives beneficial effects on human well-being. Prairie vole is a monogamous rodent. In the current study, we showed that pair bonding between mates blunted the fear responses in male prairie voles. Immunohistological analyses revealed the increase of oxytocin immunoreactivity in the paraventricular nucleus of the hypothalamus. The number of cFos positive cells was increased in the central amygdala of bonded male voles during a fear memory test. The intracerebroventricular administration of an oxytocin antagonist reversed such effects, suggesting a crucial role of the oxytocin signal in pair bonding-dependent social buffering.
Our results provide basic knowledge for developing cure and treatment of psychiatric disorders caused by impaired fear learning such as PTSD.
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