| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Alzheimer's disease is a complex disease and the patients are heterogeneou. We have addressed this difficulty by noting that the susceptibility of Alzheimer's pathology to mouse strains varies greatly. We have identified KLC1 slice variant E as a regulator of the amount of Aβ accumulation by comprehensive gene research in mice. In this study, we found that the risk gene X (not open to the public) of Alzheimer's disease, whose function was unknown, strongly regulates KLC1 splicing. Omics study uncover the connection betseen Alzheimer risk gene X and KLC1. in vitro and in vivo studies confirmed the regulation of KLC1 splicing by gene X.
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