A study of early detection of amiloid deposition and finding out the clinical state of Alzheimer's disease

• Project/Area Number: 17K10303
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Osaka University
• Principal Investigator: Yoshiyama Kenji 大阪大学, 医学系研究科, 講師 (20426498)
• Co-Investigator(Kenkyū-buntansha): 高橋 洋人 大阪大学, 医学系研究科, 講師 (20617352) ; 梶本 勝文 大阪大学, 医学系研究科, 特任助教(常勤) (30403067) ; 安野 史彦 国立研究開発法人国立長寿医療研究センター, 病院, 医長 (60373388)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: アルツハイマー病 / アミロイドβ / 頭部MRI / 脳脊髄液 / 特発性正常圧水頭症 / 認知症 / 脳神経疾患

Outline of Final Research Achievements

Early detection and early treatment of Alzheimer’s disease, which is the major cause of dementia, are important. The accumulation of amyloid β protein in the brain is the cause of Alzheimer’s disease and is examined only by the cerebrospinal fluid or amyloid PET. In this study, we aimed to examine the accumulation of amyloid β by the head MRI that is usually used in a clinical scene.

Academic Significance and Societal Importance of the Research Achievements

認知症の原因となる疾患で、過半数を占めるのがアルツハイマー病であり、その治療については、症状がある程度進行してからでは遅く、いかに早期に診断して治療に結び付けるかが重要である。本研究において、臨床面で用いられることが多い頭部MRIを用いて、早期のアルツハイマー病の診断がつくことが可能となれば、アルツハイマー病の早期診断を広く行うことが可能となり、認知症の臨床場面に貢献できる。

Research Products

• [Journal Article] Cerebral blood flow and Alzheimer's disease-related biomarkers in cerebrospinal fluid in idiopathic normal pressure hydrocephalus. (2019)
  • Author(s): Azuma S, Kazui H, Kanemoto H, Suzuki Y, Sato S, Suehiro T, Matsumoto T, Yoshiyama K, Kishima H, Shimosegawa E, Tanaka T, Ikeda M.
  • Journal Title: Psychogeriatrics. Volume: 印刷中 Issue: 6 Pages: 527-538
  • DOI: 10.1111/psyg.12435
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mutual effect of cerebral amyloid β and peripheral lymphocytes in cognitively normal older individuals (2017)
  • Author(s): Yasuno F, Kazui H, Kajimoto K, Ihara M, Morita N, Taguchi A, Yamamoto A, Matsuoka K, Takahashi M, Nakagawara J, Tsuji M, Iida H, Kishimoto T, Nagatsuka K
  • Journal Title: Int J Geriatr Psychiatry Volume: 32 Issue: 12
  • DOI: 10.1002/gps.4660
  • Peer Reviewed
• [Journal Article] Use of T1-weighted/T2-weighted magnetic resonance ratio to elucidate changes due to amyloid-β accumulation in cognitively normal subjects. (2016)
  • Author(s): Yasuno F, Kazui H, Morita N, Kajimoto K, Ihara M, Taguchi A, Yamamoto A, Matsuoka K, Takahashi M, Nakagawara J, Iida H, Kishimoto T, Nagatsuka K
  • Journal Title: Neuroimage Clin Volume: 13 Pages: 209-214
  • DOI: 10.1016/j.nicl.2016.11.029
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Association between high biomarker probability for Alzheimer’s disease and change in quantitative regional cerebral blood flow after shunt surgery in patients with idiopathic normal pressure hydrocephalus (2017)
  • Author(s): Azuma S, Kazui H, Matsumoto T, Suehiro T, Sato S, Suzuki Y, Kanemoto H, Yoshiyama K, Kishima H, Ikeda M
  • Organizer: Hydrocephalus 2017
  • Int'l Joint Research
• [Presentation] 特発性正常圧水頭症患者におけるシャント術前後の血流変化と脳脊髄液マーカーとの関係 (2017)
  • Author(s): 東 眞吾 、数井 裕光 、松本 拓也 、末廣 聖 、佐藤 俊介 、鈴木 由希子、鐘本 英輝 、吉山 顕次 、貴島 晴彦、池田 学
  • Organizer: 第18回正常圧水頭症学会