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Search for treatment mechanism and treatment response predictor of major depression by repetitive transcranial magnetic stimulation

Research Project

Project/Area Number 17K10307
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionSaga University

Principal Investigator

Tateishi Hiroshi  佐賀大学, 医学部, 助教 (50457470)

Co-Investigator(Kenkyū-buntansha) 門司 晃  佐賀大学, 医学部, 教授 (00294942)
浅見 豊子  佐賀大学, 医学部, 准教授 (20222599)
西原 正志  佐賀大学, 医学部, 助教 (50516557)
川口 淳  佐賀大学, 医学部, 教授 (60389319)
大塚 貴輝  佐賀大学, 医学部, 助教 (70363439)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords反復経頭蓋磁気刺激 / 治療抵抗性うつ病 / 認知機能 / 炎症性サイトカイン / 生化学的指標 / 生物化学的指標 / 前頭葉機能 / 拡散テンソル画像 / 神経科学
Outline of Final Research Achievements

From August 2013, rTMS was started for patients with major depression, and by March 2020, rTMS was performed for 32 cases. Based on the above studies,Although rTMS resulted in partial improvement of frontal lobe dysfunction as well as white matter integrity, we found no correlation between improved frontal lobe dysfunction and improved white matter integrity in treatment-resistant depression patients. In addition, there was no significant change in inflammatory cytokines alone (IL-1β, IL-6, TNF-α) before and after rTMS treatment, but partial changes in cognitive function and changes in IL-1β were significantly correlated.

Academic Significance and Societal Importance of the Research Achievements

rTMSによる治療抵抗性うつ病患者の大脳白質構造を反映する異方分画性(FA)と認知機能との関連を研究した報告及び認知機能と炎症性サイトカインとの関連を調べた報告はこれまでになく、今回の結果は貴重である。特に後者の結果から、rTMSによる治療抵抗性うつ病の認知機能障害の改善に血清IL-1βの低下が何らかの形で関与している可能性が示唆された。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (10 results)

All 2020 2019 2018

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Changes in interleukin-1 beta induced by rTMS are significantly correlated with partial improvement of cognitive dysfunction in treatment-resistant depression: a pilot study2020

    • Author(s)
      Hiroshi Tateishi, Yoshito Mizoguchi, Atsushi Kawaguchi, Yoshiomi Imamura, Jun Matsushima, Hiroko Kunitake, Toru Murakawa, Yoshinori Haraguchi, Yutaka Kunitake, Toshihiko Maekawa, Takahiro A. Kato, Toyoko Asami, Akira Monji
    • Journal Title

      Psychiatry Research

      Volume: 289 Pages: 112995-112995

    • DOI

      10.1016/j.psychres.2020.112995

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of frontal lobe dysfunction and white matter integrity by rTMS in treatment-resistant depression2019

    • Author(s)
      Tateishi H, Nishihara M, Kawaguchi A, Matsushima J, Murakawa T, Haraguchi Y, Kunitake Y, Maekawa T, Kato TA, Asami T, Mizoguchi Y, Monji A
    • Journal Title

      Neuropsychiatric Disease and Treatment

      Volume: 15 Pages: 3079-3079

    • DOI

      10.2147/ndt.s228501

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] rTMSによるうつ病治療における臨床的バイオマーカー2018

    • Author(s)
      立石 洋、門司 晃
    • Journal Title

      臨床精神医学

      Volume: 47(8) Pages: 905-912

    • Related Report
      2018 Research-status Report
  • [Presentation] 佐賀大学病院におけるrTMS臨床研究の現状と課題2020

    • Author(s)
      立石 洋
    • Organizer
      第116回日本精神神経学会学術総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 治療抵抗性うつ病に対するrTMSにおける治療効果の1年転帰2020

    • Author(s)
      立石 洋
    • Organizer
      第116回日本精神神経学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 難治性うつ病に対するrTMSにおける前頭葉機能改善と炎症系バイオマーカーの変化との相関2019

    • Author(s)
      立石 洋
    • Organizer
      第115回日本精神神経学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 難治性うつ病に対するrTMSにおける前頭葉機能改善と炎症系バイオマーカーの変化との相関2019

    • Author(s)
      立石 洋
    • Organizer
      第41回日本生物学的精神医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 難治性うつ病に対するrTMSは前頭葉機能の改善を伴い、神経ネットワークの結合性を高める2018

    • Author(s)
      立石 洋、西原正志、川口 淳、松島 淳、稻葉隆繕、村川 徹、諸隈 暢、菊地 潤、酒村勇太、福地絢子、浅見豊子、溝口義人、門司 晃
    • Organizer
      第114回日本精神神経学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Correlation between the frontal lobe function and the white matter structure in patients with depression2018

    • Author(s)
      Hiroshi Tateishi, Masashi Nishihara, Atsushi Kawaguchi, Jun Matsushima, Toru Murakawa, Yoshinori Haraguchi, Yutaka Kunitake, Toshihiko Maekawa, Takahiro A Kato, Yoshito Mizoguchi , Akira Monji
    • Organizer
      The 40th Annual meeting of Japanese society of biological psychiatry
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 難治性うつ病に対するrTMSは前頭葉機能の改善を伴い、神経ネットワークの結合性を高める2018

    • Author(s)
      立石洋、門司晃、浅見豊子、西原正志、川口淳、大塚貴輝
    • Organizer
      日本精神神経学会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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