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The investigation regarding interactive mechanism between Alzheimer disease and ideopathic normal pressure hydrocephalus

Research Project

Project/Area Number 17K10310
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionOsaka University (2019-2020)
Kumamoto University (2017-2018)

Principal Investigator

Hashimoto Mamoru  大阪大学, 医学系研究科, 准教授 (20452881)

Co-Investigator(Kenkyū-buntansha) 福原 竜治  熊本大学, 病院, 講師 (60346682)
石川 智久  熊本大学, 病院, 助教 (60419512)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsアルツハイマー病 / 特発性正常圧水頭症 / 発現機序 / DESH / MRI / 相互作用 / 認知症
Outline of Final Research Achievements

We tested the hypothesis that Alzheimer's disease (AD) pathology may contribute to the development of idiopathic normal pressure hydrocephalus (iNPH). The subjects were 461 patients with probable AD. MRI disproportionately enlarged subarachnoid-space hydrocephalus (DESH) features, which is a hallmark for iNPH on brain MRI were visually evaluated.
We found that 10.6% of patients with AD showed the MRI DESH features, which was significantly higher than those in previous Japanese community-based studies. The frequencies of gait disturbance and urinary incontinence were significantly higher in the DESH positive patients than those in the DESH negative patients. Multiple logistic regression analysis revealed that the development of the MRI DESH features was significantly associated with the presence of diabetes mellitus and the presence of periventricular white matter hyperintensities on MRI.
These findings indicate the possibility that AD pathology contributes to the development of iNPH.

Academic Significance and Societal Importance of the Research Achievements

本研究結果から、アルツハイマー病(AD)患者は特発性正常圧水頭症(iNPH)を合併しやすいこと、すなわちAD病理がiNPHを誘発する可能性が示された。現在ADに対する根本的な治療方法は存在しない。しかしながら本研究結果は、脳脊髄液シャント手術や脳脊髄液循環動態の改善に作用する薬剤が、ADの病態や臨床症状の改善に有効である可能性を示唆しており、今後のAD治療薬の開発や治療介入方法を検討する上で重要な知見である。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (34 results)

All 2021 2020 2019 2018 2017

All Journal Article (17 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 13 results,  Open Access: 7 results) Presentation (17 results) (of which Invited: 4 results)

  • [Journal Article] Clinical features of behavioral symptoms in patients with semantic dementia: Does semantic dementia cause autistic traits?2021

    • Author(s)
      Sakuta S, Hashimoto M, Ikeda M, Koyama A, Takasaki A, Hotta M, Fukuhara R, Ishikawa T, Yuki S, Miyagawa Y, Hidaka Y, Kaneda K, Takebayashi M.
    • Journal Title

      PLoS ONE

      Volume: 16(2) Issue: 2 Pages: 1-13

    • DOI

      10.1371/journal.pone.0247184

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between executive dysfunction and neuropsychiatric symptoms and impaired instrumental activities of daily living among patients with very mild Alzheimer's disease2020

    • Author(s)
      Ikezaki H, Hashimoto M, Ishikawa T, Fukuhara R, Tanaka H, Yuki S, Kuribayashi K, Hotta M, Koyama A, Ikeda M, Takebayashi M
    • Journal Title

      Int J Geriatr Psychiatry

      Volume: 35 Issue: 8 Pages: 877-887

    • DOI

      10.1002/gps.5308

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-Related Changes in Instrumental and Basic Activities of Daily Living Impairment in Older Adults with Very Mild Alzheimer’s Disease.2020

    • Author(s)
      Tabira T, Hotta M, Murata M, Yoshiura K, Han G, Ishikawa T, Koyama A, Ogawa N, Maruta M, Ikeda Y, Mori T, Yoshida T, Hashimoto M, Ikeda M.
    • Journal Title

      Dement Geriatr Cogn Disord Extra

      Volume: 10 Issue: 1 Pages: 27-37

    • DOI

      10.1159/000506281

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 行動障害型前頭側頭型認知症と自閉症スペクトラム症との鑑別2020

    • Author(s)
      佐久田静、橋本衛
    • Journal Title

      精神医学

      Volume: 62 Pages: 151-161

    • Related Report
      2019 Research-status Report
  • [Journal Article] Cerebral Microbleeds are Associated with Cerebral Hypoperfusion in Patients with Alzheimer’s Disease.2019

    • Author(s)
      Hatada H, Hashimoto M, Shiraishi S, Ishikawa T, Fukuhara R, Yuki S, Tanaka H, Miyagawa Y, Kitajima M, Uetani H, Tsunoda N, Koyama A, Ikeda M.
    • Journal Title

      J Alzheimers Dis

      Volume: 71 Issue: 1 Pages: 273-280

    • DOI

      10.3233/jad-190272

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Delusional parasitosis in dementia with Lewy bodies: a case report.2019

    • Author(s)
      Ochiai S, Sugawara H, Kajio Y, Tanaka H, Ishikawa T, Fukuhara R, Jono T, Hashimoto M.
    • Journal Title

      Ann Gen Psychiatry.

      Volume: 18 Issue: 1 Pages: 1-3

    • DOI

      10.1186/s12991-019-0253-3

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 認知症患者の妄想の発現に関わる要因について2019

    • Author(s)
      橋本衛
    • Journal Title

      Dementia Japan

      Volume: 33 Pages: 215-223

    • NAID

      130007777413

    • Related Report
      2019 Research-status Report
  • [Journal Article] 認知症患者に病識は必要か?2019

    • Author(s)
      橋本衛
    • Journal Title

      精神医学

      Volume: 61 Pages: 1393-1402

    • Related Report
      2019 Research-status Report
  • [Journal Article] Clinical features of auditory hallucinations in patients with DLB: A soundtrack of visual hallucinations.2018

    • Author(s)
      Tsunoda N, Hashimoto M, Ishikawa T, Fukuhara R, Yuki S, Tanaka T, Hatada Y, Miyagawa Y, Ikeda M.
    • Journal Title

      J Clin Psychiatry

      Volume: 79 Issue: 3

    • DOI

      10.4088/jcp.17m11623

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Are saving appearance responses typical communication patterns in Alzheimer's disease?2018

    • Author(s)
      Matsushita M, Yatabe Y, Koyama A, Katsuya A, Ijichi D, Miyagawa Y, Ikezaki H, Furukawa N, Ikeda M, Hashimoto M.
    • Journal Title

      PLoS One

      Volume: 13 Issue: 5 Pages: 1-9

    • DOI

      10.1371/journal.pone.0197468

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Caregiver burden in semantic dementia with right- and left-sided predominant cerebral atrophy and in behavioral variant frontotemporal dementia.2018

    • Author(s)
      Koyama A, Hashimoto M, Fukuhara R, Ichimi N, Takasaki A, Matsushita M, Ishikawa T, Tanaka H, Miyagawa Y, Ikeda M.
    • Journal Title

      Dementia and Cognitive Disorders EXTRA

      Volume: 8 Issue: 1 Pages: 128-137

    • DOI

      10.1159/000487851

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differentiating between Alzheimer Disease Patients and Controls with Phase-difference-enhanced Imaging at 3T: A Feasibility Study2018

    • Author(s)
      Tateishi Machiko、Kitajima Mika、Hirai Toshinori、Yoneda Tetsuya、Hashimoto Mamoru、Kurehana Nan、Uetani Hiroyuki、Fukuhara Ryuji、Azuma Minako、Yamashita Yasuyuki
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 17 Issue: 4 Pages: 283-292

    • DOI

      10.2463/mrms.mp.2017-0134

    • NAID

      130007496648

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 軽度認知障害と森田療法2018

    • Author(s)
      橋本 衛
    • Journal Title

      日本森田療法学会雑誌

      Volume: 29 Pages: 907-914

    • Related Report
      2018 Research-status Report
  • [Journal Article] Clinical features of auditory hallucinations in patients with DLB: A soundtrack of visual hallucinations.2018

    • Author(s)
      Tsunoda N, Hashimoto M, Ishikawa T, Fukuhara R, Yuki S, Tanaka T, Hatada Y, Miyagawa Y, Ikeda M
    • Journal Title

      J Clin Psychiatry

      Volume: 印刷中

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effectiveness of educational program using printed educational material on care burden distress among staff of residential aged care facilities without medical specialists and/or registered nurses: Cluster quasi-randomization study2017

    • Author(s)
      Fukuda Koji、Terada Seishi、Hashimoto Mamoru、Ukai Katsuyuki、Kumagai Ryo、Suzuki Mizue、Nagaya Masahiro、Yoshida Mika、Hattori Hideyuki、Murotani Kenta、Toba Kenji
    • Journal Title

      Geriatr Gerontol Int.

      Volume: 18 Issue: 3 Pages: 487-494

    • DOI

      10.1111/ggi.13207

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Why do people with dementia pretend to know the correct answer? A qualitative study on the behaviour of toritsukuroi to keep up appearances, Psychogeriatrics2017

    • Author(s)
      Matsushita M., Yatabe Y., Koyama A., Ueno Y., Ijichi D., Ikezaki H., Hashimoto M., Furukawa N., Ikeda M.
    • Journal Title

      Psychogeriatrics

      Volume: 4 Issue: 6 Pages: 001-001

    • DOI

      10.1111/psyg.12253

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Face-specific memory deficits and changes in eye scanning patterns among patients with amnestic mild cognitive impairment2017

    • Author(s)
      Kawagoe Toshikazu、Matsushita Masateru、Hashimoto Mamoru、Ikeda Manabu、Sekiyama Kaoru
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s41598-017-14585-5

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] BPSDとその責任病巣について2020

    • Author(s)
      橋本衛
    • Organizer
      第35回日本老年精神医学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 外来におけるBPSDの早期診断と介入について2020

    • Author(s)
      橋本衛
    • Organizer
      第39回日本認知症学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] レビー小体型認知症の介護負担について2020

    • Author(s)
      橋本衛
    • Organizer
      第14回レビー小体型認知症研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 精神科におけるiNPH診療の課題2020

    • Author(s)
      橋本衛
    • Organizer
      沖縄県特発性正常圧水頭症シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] MRI上でDESH所見を持つが他覚的にはiNPHの3徴を有さない群における精神症状の検討2020

    • Author(s)
      小泉冬木、末廣聖、鐘本英輝、吉山顕次、和田民樹、松本拓也、欠田恭輔、佐竹祐人、橋本衛、池田学
    • Organizer
      第21回日本正常圧水頭症学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 初期認知症患者の心理状態を考慮したBPSDの予防と対応の試み2019

    • Author(s)
      橋本 衛
    • Organizer
      第38回日本認知症学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 行動障害型前頭側頭型認知症(bvFTD)の臨床症候の特徴-鑑別診断を中心に-2019

    • Author(s)
      橋本 衛
    • Organizer
      第38回日本認知症学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] アルツハイマー病患者における誤認妄想の神経基盤について2019

    • Author(s)
      橋本 衛、福原竜治、津野田尚子、竹林実
    • Organizer
      第115回日本精神神経学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] アルツハイマー病患者における妄想の神経基盤について2019

    • Author(s)
      橋本 衛,福原竜治,津野田尚子
    • Organizer
      第24回日本神経精神医学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 若年性認知症と注意欠如多動性障害2018

    • Author(s)
      橋本 衛
    • Organizer
      第33回日本老年精神医学会
    • Related Report
      2018 Research-status Report
  • [Presentation] DLBの精神症状が認知機能変動に及ぼす影響について2018

    • Author(s)
      橋本 衛
    • Organizer
      第23回日本神経精神医学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] BPSDに対する非薬物療法2018

    • Author(s)
      橋本 衛
    • Organizer
      第37回日本認知症学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 認知症における妄想の神経基盤と治療2017

    • Author(s)
      橋本 衛
    • Organizer
      第39回生物学的精神医学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 軽度認知障害と森田療法2017

    • Author(s)
      橋本 衛
    • Organizer
      第35回日本森田療法学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 地域における認知症診療体制2017

    • Author(s)
      橋本 衛
    • Organizer
      第36回日本認知症学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 認知症患者の妄想の発現に関わる要因について2017

    • Author(s)
      橋本 衛
    • Organizer
      第36回日本認知症学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] アルツハイマー病(AD)と特発性正常圧水頭症(iNPH)の合併についての検討2017

    • Author(s)
      橋本 衛
    • Organizer
      第23回熊本脳機能画像研究会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2022-01-27  

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