| Project/Area Number |
17K10312
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
橋本 恵理 札幌医科大学, 医学部, 准教授 (30301401)
鵜飼 渉 札幌医科大学, 医療人育成センター, 准教授 (40381256)
相馬 仁 札幌医科大学, 医療人育成センター, 教授 (70226702)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | DLB / DAT-SPECT / 脳血流SPECT / 老年精神医学 / 認知症 / MIBG心筋シンチ |
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| Outline of Final Research Achievements |
The basal ganglia (striatum) is the most important interest domain in DLB.
However, to the best of our knowledge, there are few and not enough studies that evaluated the perfusion of every part of brain statistically.
Knowledge about which part of brain perfusion on SPECT has correlation with each symptom of DLB would be helpful for optimum management including the provision of appropriate information for patients and caregivers, the initiation of effective treatments, and particularly the avoidance of potentially life-threatening antipsychotic drugs.
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| Academic Significance and Societal Importance of the Research Achievements |
DLBのそれぞれの症状が、線条体におけるDAT-SPECT や脳血流SPECTの所見と関連があるか、また他の部位の血流とも相関があるか等が明らかになれば、患者や介護者に適切な情報提供を行ったり、抗精神病薬の副作用を避け、効果的な治療方法を選択するなど、最適なマネジメントをする助けになると思われる。また、今回の結果を踏まえて、安全かつ効率的な治療法の確立に貢献できれば、医療経済的見地からも社会に与える利益は大きく、非常に大きな意義を有するものであると考える。
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