The mechanisms of electroconvulsive therapy: a multimodal longitudinal study.
| Project/Area Number |
17K10315
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Keio University |
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Principal Investigator |
HIRANO Jinichi 慶應義塾大学, 医学部(信濃町), 特任講師 (60574910)
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| Co-Investigator(Kenkyū-buntansha) |
山縣 文 慶應義塾大学, 医学部(信濃町), 講師 (30439476)
杉浦 悠毅 慶應義塾大学, 医学部(信濃町), 講師 (30590202)
内田 裕之 慶應義塾大学, 医学部(信濃町), 准教授 (40327630)
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| Project Period (FY) |
2017-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2020: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | うつ病 / 電気けいれん療法 / 磁気共鳴画像 / 脳波 / 気分障害 / 脳画像 / 精神医学 / 電気けいれん / 脳・神経 / Magnet Resonance Imaging / 近赤外線スペクトロスコピィ |
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| Outline of Final Research Achievements |
Twenty-five cases were registered. No adverse event was admitted. Increasing the hippocampal volume after electroconvulsive therapy might be specific and play a central role in the treatment mechanism of electroconvulsive therapy. Like previous studies, we also identified white matter changes in diffusion tensor imaging and functional connectivity changes on resting-state functional MRI.
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| Academic Significance and Societal Importance of the Research Achievements |
うつ病は生活の質に与える影響が大きい疾病とされている。うつ病に対しては認知行動療法や薬物療法が行われるが、治療反応が示されなかった症例は治療抵抗性うつ病とされ、電気けいれん療法の適応とされる。電気けいれん療法の作用機序において海馬容積増大の関与が示唆されたことは、難治性うつ病の回復過程の神経学的基盤の解明に寄与したと考えられる。
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Report
(6 results)
Research Products
(10 results)
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[Presentation] Individual prediction for remission following electroconvulsive therapy using machine learning.2021
Author(s)
Nakajima K, Takamiya A, Kudo S, Minami, F, Kuo-ching Liang, Kishimoto T, Kikuchi, T, Yamagata B, Mimura M, Hirano J.
Organizer
International Society for Electroconvulsive therapy and Neurostimulation (ISEN)
Related Report
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