Elucidation of the mechanism of behavioral and psychological symptoms in Alzheimer's disease patients using DNA methylation
| Project/Area Number |
17K10317
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | Jikei University School of Medicine |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2017-04-01 – 2021-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | BPSD / 興奮 / 認知症 / アルツハイマー病 / DNAメチル化 / 遺伝子 / 行動・心理症状 |
|---|
| Outline of Final Research Achievements |
Agitation is the most common and difficult to treat among behavioral and psychological symptoms of dementia (BPSD) . The objective of this study was to identify a region where changes in DNA methylation levels are associated with agitation. Using genome-wide DNA methylation analysis data, we determined a signaling pathway in the WNT5A gene promoter region to be associated with agitation. Based on this result, we measured DNA methylation levels in this region for 26 dementia subjects with agitation and 82 dementia subjects without agitation. The WNT5A DNA methylation level in subjects with agitation was significantly lower than in those without agitation. This change was not influenced by age, sex, body mass index, APOE ε4, medication or inflammatory cytokines. This results suggested an association of agitation with changes in WNT5A DNA methylation levels, which could be a potentially useful biomarker of agitation. It may contribute to the elucidation of the mechanism of BPSD.
|
| Academic Significance and Societal Importance of the Research Achievements |
血液を利用した簡便に実施可能なバイオマーカーが実現すれば、速やかで適正な治療法の選択が可能となる。臨床医の視点に立脚したものとして、患者のQOLの向上と介護負担の軽減に繋がり、社会的な意義は大きい。
|
Report
(5 results)
Research Products
(2 results)
