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A randomized study on the effect of tDCS on cognitive function in schizophrenia

Research Project

Project/Area Number 17K10321
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

Sumiyoshi Tomiki  国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所 児童・予防精神医学研究部, 部長 (80286062)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords統合失調症 / 経頭蓋直流刺激 / 認知機能 / 日常生活技能 / 社会機能 / 近赤外線光トポグラフィー / ニューロモデュレーション / 認知機能障害 / 認知機能評価 / 社会機能的能力
Outline of Final Research Achievements

We sought to determine whether oxy-hemoglobin ([oxy-Hb]), measured by near-infrared spectroscopy (NIRS), is associated with effects of transcranial direct current stimulation (tDCS) on psychotic symptoms of schizophrenia. Significant negative correlation was demonstrated between [oxy-Hb] concentrations of left temporoparietal regions throughout verbal fluency tasks vs. changes of the Positive and Negative Syndrome Scale - Positive and Negative subscale scores. This is the first study to demonstrate the correlation between the response of neural activity to cognitive tasks at baseline and the ability of tDCS to improve positive and negative psychotic symptoms. Our observations suggest that NIRS provides a marker to predict the response to treatment with tDCS in schizophrenia.

Academic Significance and Societal Importance of the Research Achievements

本研究により、統合失調症患者の認知機能および社会機能的能力をtDCSが改善することが、客観的かつ精緻に示されると予想された。以上より、精神疾患を有する患者の社会復帰に向けた、従来のアプローチとは異なる新たな治療法の創出につながると期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (12 results)

All 2019 2018 2017

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 2 results) Presentation (3 results) (of which Int'l Joint Research: 3 results,  Invited: 3 results) Book (2 results)

  • [Journal Article] Meta-Analysis of the Effect of Multisession Transcranial Direct Current Stimulation on Cognition in Dementia and Mild Cognitive Impairment2019

    • Author(s)
      157. Inagawa T, Narita Z, Sugawara N, Maruo K, Stickley A, Yokoi Y, Sumiyoshi T.
    • Journal Title

      Clin EEG Neurosci

      Volume: 50 Issue: 4 Pages: 273-282

    • DOI

      10.1177/1550059418800889

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of transcranial direct current stimulation on psychotic symptoms of schizophrenia is associated with oxy-hemoglobin concentrations in the brain as measured by near-infrared spectroscopy: A pilot study.2018

    • Author(s)
      Narita Z, Noda T, Setoyama S, Sueyoshi K, Inagawa T, Sumiyoshi T.
    • Journal Title

      J Psychiatr Res.

      Volume: 103 Pages: 5-9

    • DOI

      10.1016/j.jpsychires.2018.05.004

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Reliability and validity of the California Verbal Learning Test-II - Japanese version2017

    • Author(s)
      Sumiyoshi Tomiki、Toyomaki Atsuhito、Kawano Naoko、Kitajima Tomoko、Kusumi Ichiro、Ozaki Norio、Iwata Nakao、Nakagome Kazuyuki
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 71 Issue: 6 Pages: 417-418

    • DOI

      10.1111/pcn.12525

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Verbal memory impairments in bipolar disorder: Effect of type of word learning tasks2017

    • Author(s)
      Sumiyoshi Tomiki、Toyomaki Atsuhito、Kawano Naoko、Kitajima Tomoko、Kusumi Ichiro、Ozaki Norio、Iwata Nakao、Sueyoshi Kazuki、Nakagome Kazuyuki
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 71 Issue: 8 Pages: 570-571

    • DOI

      10.1111/pcn.12536

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of Transcranial Direct Current Stimulation on Functional Capacity in Schizophrenia: A Study Protocol for a Randomized Controlled Trial2017

    • Author(s)
      Narita Zui、Inagawa Takuma、Maruo Kazushi、Sueyoshi Kazuki、Sumiyoshi Tomiki
    • Journal Title

      Frontiers in Psychiatry

      Volume: 8 Pages: 1-1

    • DOI

      10.3389/fpsyt.2017.00233

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quality of life in individuals with attenuated psychotic symptoms: Possible role of anxiety, depressive symptoms, and socio-cognitive impairments2017

    • Author(s)
      Takahashi T., Higuchi Y., Komori Y., Nishiyama S., Nakamura M., Sasabayashi D., Nishikawa Y., Sumiyoshi T., Suzuki M
    • Journal Title

      Psychiatry Research

      Volume: 257 Pages: 431-7

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Possible Facilitative Effects of Repeated Anodal Transcranial Direct Current Stimulation on Functional Outcome 1 Month Later in Schizophrenia: An Open Trial2017

    • Author(s)
      Narita Zui、Inagawa Takuma、Sueyoshi Kazuki、Lin Crystal、Sumiyoshi Tomiki
    • Journal Title

      Frontiers in Psychiatry

      Volume: 8 Pages: 1-1

    • DOI

      10.3389/fpsyt.2017.00184

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Disturbances of memory organization in schizophrenia; a cohort study2019

    • Author(s)
      37. Sumiyoshi T
    • Organizer
      19th WPA World Congress of Psychiatry
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] EEG and neurocognitive markers of psychosis vulnerability2017

    • Author(s)
      Sumiyoshi T. and Higuchi Y
    • Organizer
      WPA XVII World Congress of Psychiatry
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Real-world functional outcome in schizophrenia: clinical features mediating its heterogeneity2017

    • Author(s)
      Sumiyoshi T
    • Organizer
      WPA XVII World Congress of Psychiatry
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Book] Cognitive Enhancement in Psychiatric Disorders2019

    • Author(s)
      Sumiyoshi T, Toyomaki A, Kawano N, Kitajima T, Kusumi I, Ozaki N, Iwata N, Sueyoshi K, Nakagome K
    • Total Pages
      260
    • Publisher
      Frontiers Media
    • ISBN
      9782889630554
    • Related Report
      2019 Annual Research Report
  • [Book] 精神医学症候群(第2版)2017

    • Author(s)
      末吉一貴、住吉太幹
    • Total Pages
      627
    • Publisher
      日本臨床社
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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