Neural mechanisms of cognitive inflexibility and attention-shifting in autism spectrum disorder
| Project/Area Number |
17K10326
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kyoto University |
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Principal Investigator |
Tei Shisei 京都大学, 医学研究科, 客員研究員 (00621575)
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| Co-Investigator(Kenkyū-buntansha) |
藤野 純也 昭和大学, 大学共同利用機関等の部局等, 講師 (90783340)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 柔軟性 / 注意機能 / 発達障害 / 意思決定 / 共感 / 注意 / 視点 / 社会性 / 注意切り替え / 視点転換 / 視点の転換 / 脳神経疾患 / 医療・福祉 |
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| Outline of Final Research Achievements |
Individuals with autism spectrum disorder (ASD) frequently report difficulty in flexible responding to social situations. However, the underlying neurocognitive mechanism remains insufficiently explored. We investigated this issue in related to attention shifting functions. We found decreased flexible and attention processing among participants with ASD, as compared to those with typical development. Moreover, we also observed a link between participants’ capacity in flexible decision-making and attention shifting. These findings, together with our brain-imaging findings, support the recent idea that the inflexible behaviors in people with ASD may be crucially owing to their decreased situational understanding and/or reduced awareness of the social context; and that these phenomena might stem from their decreased and/or altered attention shifting.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、ASDの柔軟性低下の背景にある認知・脳内メカニズムを調査した。この結果、神経心理・脳機能の観点から新たなエビデンスを提供する事ができた。本研究の結果、ASDにおける低次の注意・視点の切り替えの変調は、共感・自己ー他者理解を介し、高次の様々な柔軟な社会的意思決定に影響を及ぼす可能性が示唆された。これらの結果は、ASDのみならず社会的柔軟さの低下が関わる病態を理解する上でも有用であり、今後研究を進めていく上でも重要な基盤となりうる。さらにこれらの知見は、社会適応能力を効果的に高める臨床介入を考える上でも有益な情報となると考えている。
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Report
(5 results)
Research Products
(34 results)
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[Journal Article] Attitudes toward risk and ambiguity in patients with autism spectrum disorder.2017
Author(s)
藤野純也, Tei S, 橋本龍一郎, 板橋貴史, 太田晴久, 金井智恵子, 岡田理恵子, 久保田学, 中村元昭, 加藤進昌, 高橋英彦
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Journal Title
Mol Autism
Volume: 16
Issue: 1
Pages: 45-45
DOI
Related Report
Peer Reviewed / Open Access
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