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A study to understand traumatic brain injury from multiple aspects, as a complex of 4 syndromes.

Research Project

Project/Area Number 17K10327
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKyoto University

Principal Investigator

Ueda Keita  京都大学, 医学研究科, 講師 (60573079)

Co-Investigator(Kenkyū-buntansha) 杉原 玄一  京都大学, 医学研究科, 助教 (70402261)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords外傷性脳損傷 / 神経心理学 / 高次脳機能障害 / 神経画像 / 脳萎縮 / MRI / アミロイド / コネクトーム / 神経心理 / 意識障害 / 脳幹体積 / 神経科学
Outline of Final Research Achievements

In this study, we investigated brain volume reduction and connectivity changes after traumatic brain injury mainly caused by traffic accident. The volume reduction in brain stem was closely related with the severity in acute stage of brain injury. Connectivity between corpus callosum and several grey matter region was revealed but there was no significant correlation between FA value of the fiber and its corresponding grey matter volume. By lag mapping method, it was suggested that venous resistance was elevated in superficial venous system after brain injury and it has some effect on ventricular dilation. In summary, after traumatic brain injury, some different pathological changes occurred and had effect on grey matter, white matter and ventricle volumes. In future, further investigation with 7T MRI and brain damage effect on the symptoms would be necessary.

Academic Significance and Societal Importance of the Research Achievements

本研究では、外傷性脳損傷後に生じる脳萎縮について、いくつかの異なる観点から研究を行い、結果として外傷性脳損傷後に生じる脳体積、脳室体積変化が、少なくとも3つの異なる機序から生じていることを明らかにした。本研究は、外傷性脳損傷の予後予測に寄与し、また背景病態ごとの治療的介入について検討する基盤的な情報を提供することになったと考えられる。交通外傷に伴う外傷性脳損傷は近年社会問題となっており、本研究は外傷性脳損傷者の社会復帰への一助となることが期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (10 results)

All 2020 2019 2018 2017

All Journal Article (5 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Invited: 3 results) Book (1 results)

  • [Journal Article] A venous mechanism of ventriculomegaly shared between traumatic brain injury and normal ageing2020

    • Author(s)
      Aso Toshihiko、Sugihara Genichi、Murai Toshiya、Ubukata Shiho、Urayama Shin-ichi、Ueno Tsukasa、Fujimoto Gaku、Thuy Dinh Ha Duy、Fukuyama Hidenao、Ueda Keita
    • Journal Title

      Brain

      Volume: 143 Issue: 6 Pages: 1843-1856

    • DOI

      10.1093/brain/awaa125

    • NAID

      120006844908

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 総説 社会的行動障害2019

    • Author(s)
      生方 志浦、上田 敬太、村井 俊哉
    • Journal Title

      BRAIN and NERVE

      Volume: 71 Issue: 10 Pages: 1091-1096

    • DOI

      10.11477/mf.1416201410

    • ISSN
      1344-8129, 1881-6096
    • Year and Date
      2019-10-01
    • Related Report
      2019 Annual Research Report
  • [Journal Article] Transcallosal Fiber Disruption and its Relationship with Corresponding Gray Matter Alteration in Patients with Diffuse Axonal Injury2018

    • Author(s)
      Ubukata Shiho、Oishi Naoya、Sugihara Genichi、Aso Toshihiko、Fukuyama Hidenao、Murai Toshiya、Ueda Keita
    • Journal Title

      Journal of Neurotrauma

      Volume: - Issue: 7 Pages: 1106-1114

    • DOI

      10.1089/neu.2018.5823

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional connectivity during monitoring for visuomotor incongruence2018

    • Author(s)
      Ohashi Yoshihiro、Kochiyama Takanori、Tsuneyoshi Katsuya、Ohigashi Yoshitaka、Murai Toshiya、Ueda Keita
    • Journal Title

      NeuroReport

      Volume: 29 Issue: 11 Pages: 917-923

    • DOI

      10.1097/wnr.0000000000001053

    • Related Report
      2018 Research-status Report
  • [Journal Article] Facial emotion recognition in patients with focal and diffuse axonal injury.2017

    • Author(s)
      Yassin W, Callahan BL, Ubukata S, Sugihara G, Murai T, Ueda K.
    • Journal Title

      Brain Injury

      Volume: 28 Issue: 5 Pages: 1-7

    • DOI

      10.1080/02699052.2017.1285052

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Apathy is not depression2019

    • Author(s)
      生方志浦、上田敬太,藤本岳,植野仙経,村井俊哉,大石直也
    • Organizer
      第24回日本神経精神医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 外傷性脳損傷に対する精神科の役割2017

    • Author(s)
      上田敬太
    • Organizer
      日本脳神経外科学会第76回学術総会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 脳損傷患者における社会行動障害 情動関連症状(特に怒り)を中心に2017

    • Author(s)
      上田敬太
    • Organizer
      平成29年度第1回支援コーディネーター会議
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 脳損傷患者における攻撃性の臨床的特徴2017

    • Author(s)
      上田敬太
    • Organizer
      攻撃性の脳内基盤 基礎と臨床 AMED脳科学研究推進プログラム「意思決定」社会行動選択に必要なマーモセット意思決定回路機構の解明
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] 対人援助職のためのこころの科学―基礎と応用2019

    • Author(s)
      藤井裕子 石井信子 上田敬太
    • Total Pages
      152
    • Publisher
      ふくろう出版
    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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