| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
For the purpose of the fusion of tumor image diagnosis and the boron neutron capture therapy, I had studied the development of the boron-containing imaging agent to have high affinity and selectivity to σ-2 receptor. Various new designed vesamicol relatives showed high affinity to σ receptor in in vitro screening. The boron-containing compound were performed the in vitro cellular uptake test using human malignant melanoma A375 cells, but the content of boron in all samples were 10 ng/mL. However, I found that new compounds having limonene frame showed 14 times more σ-2 receptor affinity than σ-1 receptor affinity.
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