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Carbon dioxide dissolved in physiological saline: Application for contrast media

Research Project

Project/Area Number 17K10360
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionShiga University of Medical Science

Principal Investigator

Ota Shinichi  滋賀医科大学, 医学部, 講師 (30583637)

Co-Investigator(Kenkyū-buntansha) 園田 明永  滋賀医科大学, 医学部, 講師 (00571051)
新田 哲久  滋賀医科大学, 医学部, 非常勤講師 (40324587)
渡邉 尚武  滋賀医科大学, 医学部, 客員助教 (60570364)
井上 明星  滋賀医科大学, 医学部, 非常勤講師 (20803349)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords炭酸溶解生理食塩水 / 陰性造影剤 / 血管造影 / 炭酸ガス / 炭酸水
Outline of Final Research Achievements

Carbon dioxide dissolved in physiological saline could be used as an negative contrast media for angiographic examinations both in vitro experiments using blood vessel models and in vivo experiments using rabbits. However, compared with the carbon dioxide gas, the angiographic imaging ability was inferior when the amounts of injection volume were same. It was speculated that this limitation could be compensated by increasing its amount. In addition, there was no risk of air contamination when injecting carbon dioxide dissolved in physiological saline, which was considered to be an excellent point.

Academic Significance and Societal Importance of the Research Achievements

血管造影検査時のヨード造影剤はアレルギーや腎機能異常の患者には使用できず、その場合は陰性造影剤である二酸化炭素を用いる。しかし、ガスを注入時の採取の煩わしさ、空気のコンタミネーションの心配がある。炭酸溶解生理食塩水(はシリンジに液体を吸引するため、空気のコンタミネーションの心配や採取の煩わしさも全くない。陰性造影剤としての造影能も量を多くすれば問題なく、十分に二酸化炭素の代用になり得ると考えられた。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (7 results)

All 2019 2018

All Presentation (6 results) (of which Int'l Joint Research: 4 results) Patent(Industrial Property Rights) (1 results)

  • [Presentation] Carbon dioxide dissolved in physiological saline: application for contrast media2019

    • Author(s)
      S. Ota, A. Inoue, Y. Imai, K. Takaki, S. Sato, T. Iwai, Y. Tomozawa, Y. Murakami, A. Sonoda, N. Nitta
    • Organizer
      CIRSE 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 炭酸溶解生理食塩水:造影剤としての基礎研究2019

    • Author(s)
      大田信一、井上明星、新田哲久、高木海、 佐藤滋高、茶谷祥平、永野冬樹、神谷梓、関晃吉、永澤安子、 岩井崇泰、渡邉尚武、村上陽子、園田明永
    • Organizer
      第48回 日本IVR学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 炭酸溶解生理食塩水:造影剤としての基礎研究2019

    • Author(s)
      大田 信一
    • Organizer
      第48回 日本IVR学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Carbon dioxide dissolved in physiological saline: Application for contrast media2019

    • Author(s)
      S. Ota
    • Organizer
      CIRSE 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Carbon dioxide dissolved in physiological saline: Application for contrast media2018

    • Author(s)
      S.Ota
    • Organizer
      JSIR&ISIR2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Carbon dioxide dissolved in physiological saline: Application for contrast media2018

    • Author(s)
      Shinichi Ota
    • Organizer
      JSIR & ISIR 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] X線用陰性造影剤2018

    • Inventor(s)
      大田信一
    • Industrial Property Rights Holder
      滋賀医科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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