• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of standardized method for 11C-methionine preparation based on gas-flowlabeling method and solid-phase extraction technique.

Research Project

Project/Area Number 17K10370
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionIwate Medical University

Principal Investigator

Terasaki Kazunori  岩手医科大学, 医歯薬総合研究所, 准教授 (60285632)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsPET / 自動合成装置 / 脳腫瘍 / 放射性薬剤 / 核薬学 / 自動合成 / 固相抽出
Outline of Final Research Achievements

[11C]Methionine ([11C]MET) is the most commonly used amino acid tracer for PET imaging of brain tumor. A simple and rapid preparation of [11C]MET was achieved with “on column 11C-methylation method” and solid-phase extraction (SPE) method for the formulation. This synthesis method allows a convenient and reliable production of ethanol-free [11C]MET injection with high chemical and radiochemical purities. Further, we have developed a automatic synthesis device for [11C]MET, based on disposable cassettes for the daily routine production.

Academic Significance and Societal Importance of the Research Achievements

現在、多くのPET施設では11Cメチオニン-PETを自由診療として実施している現状がある。一方、先進医療での普及が進まない理由の一因として、合成法および合成装置の抱える課題がボトルネックになっている可能性があげられる。本研究成果として得られた[11C]MET製造法と専用合成装置は、現法に代わる安定で信頼性の高い標準法として、今後の保険診療の適用機器として進展させ、国内外の合成装置メーカーに積極的に働きかけて新たな製造技術を製品開発に結び付けていくことで、PET分野の発展に貢献できるものと期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (30 results)

All 2020 2019 2018 2017

All Journal Article (16 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 16 results,  Open Access: 8 results) Presentation (14 results) (of which Int'l Joint Research: 8 results)

  • [Journal Article] Revascularisation surgery improves cognition in adult patients with moyamoya disease.2020

    • Author(s)
      Ando T, Shimada Y, Fujiwara S, Yoshida K, Kobayashi M, Kubo Y, Terasaki K, Ando S, Ogasawara K.
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 91 Issue: 3 Pages: 332-334

    • DOI

      10.1136/jnnp-2019-321069

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decrease in 18F-Florbetapir Accumulation in the Cerebral Hemisphere With Hypoperfusion and Misery Perfusion Due to Chronic Atherosclerotic Occlusion of the Internal Carotid Artery.2020

    • Author(s)
      Takahashi T, Kobayashi M, Fujiwara S, Kubo Y, Terasaki K, Ogasawara K.
    • Journal Title

      Clin Nucl Med

      Volume: 45 Issue: 2 Pages: e115-e116

    • DOI

      10.1097/rlu.0000000000002774

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impacts on Histological Features and 11C-Methyl-L-methionine Uptake After “One-Shot” Administration with Bevacizumab Before Surgery in Newly Diagnosed Glioblastoma2019

    • Author(s)
      Beppu Takaaki、Sato Yuichi、Yamada Noriyuki、Terasaki Kazunori、Sasaki Toshiaki、Sugai Tamotsu、Ogasawara Kuniaki
    • Journal Title

      Translational Oncology

      Volume: 12 Issue: 11 Pages: 1480-1487

    • DOI

      10.1016/j.tranon.2019.08.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduced hypoxic tissue and cognitive improvement after revascularization surgery for chronic cerebral ischemia.2019

    • Author(s)
      Shimada Y, Kobayashi M, Yoshida K, Terasaki K, Fujiwara S, Kubo Y, Beppu T, Ogasawara K.
    • Journal Title

      Cerebrovasc Dis.

      Volume: 47 Issue: 1-2 Pages: 57-64

    • DOI

      10.1159/000497244

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Resolution of hypoxic tissue in cerebellar hemispheres after arterial bypass surgery in a patient with symptomatic bilateral vertebral artery occlusion: A 18F-FRP170 PET study.2019

    • Author(s)
      Oikawa K, Kobayashi M, Beppu T, Terasaki K, Ogasawara K.
    • Journal Title

      Clin Nucl Med.

      Volume: 44 Issue: 4 Pages: 295-296

    • DOI

      10.1097/rlu.0000000000002469

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comparisons between PET with 11C-methyl-L-methionine and arterial spin labeling perfusion imaging in recurrent glioblastomas treated with bevacizumab.2019

    • Author(s)
      Beppu T, Sato Y, Sasaki T, Terasaki K, Yamashita F, Sasaki M, Ogasawara K.
    • Journal Title

      Clin Nucl Med.

      Volume: 44 Issue: 3 Pages: 186-193

    • DOI

      10.1097/rlu.0000000000002417

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 18F-FDG and 11C-choline uptake in proliferating tumor cells is dependent on the cell cycle in vitro.2019

    • Author(s)
      Roppongi M, Izumisawa M, Terasaki K, Muraki Y, Shozushima M.
    • Journal Title

      Ann Nucl Med.

      Volume: 33 Issue: 4 Pages: 237-243

    • DOI

      10.1007/s12149-018-01325-6

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of effects between clopidogrel and cilostazol on cerebral perfusion in nonsurgical adult patients with symptomatically ischemic moyamoya disease: subanalysis of a prospective cohort.2018

    • Author(s)
      Chiba T, Setta K, Shimada Y, Yoshida J, Fujimoto K, Tsutsui S, Yoshida K, Kobayashi M, Kubo Y, Fujiwara S, Terasaki K, Ogasawara K.
    • Journal Title

      J Stroke Cerebrovasc Dis.

      Volume: 27 Issue: 11 Pages: 3373-3379

    • DOI

      10.1016/j.jstrokecerebrovasdis.2018.07.041

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Impact of cerebral blood flow changes due to arterial bypass surgery on cognitive function in adult patients with symptomatic ischemic moyamoya disease.2018

    • Author(s)
      Yanagihara W, Chida K, Kobayashi M, Kubo Y, Yoshida K, Terasaki K, Ogasawara K.
    • Journal Title

      J Neurosurg.

      Volume: 1 Issue: 6 Pages: 1-9

    • DOI

      10.3171/2018.7.jns18149

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Accuracy of brain perfusion single-photon emission computed tomography for detecting misery perfusion in adult patients with symptomatic ischemic moyamoya disease.2018

    • Author(s)
      Setta K, Kojima D, Shimada Y, Yoshida J, Oshida S, Fujimoto K, Tsutsui S, Chiba T, Fujiwara S, Terasaki K, Ogasawara K.
    • Journal Title

      Ann Nucl Med.

      Volume: 32 Issue: 9 Pages: 611-619

    • DOI

      10.1007/s12149-018-1283-7

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Two-year clinical, cerebral hemodynamic, and cognitive outcomes of adult patients undergoing medication alone for symptomatically ischemic moyamoya disease without cerebral misery perfusion: a prospective cohort study.2018

    • Author(s)
      Miyoshi K, Chida K, Kobayashi M, Kubo Y, Yoshida K, Terasaki K, Ogasawara K.
    • Journal Title

      Neurosurgery

      Volume: 30 Issue: 6 Pages: 234-234

    • DOI

      10.1093/neuros/nyy234

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Crossed cerebellar tracer uptake on acute-stage 123I-iomazenil SPECT imaging predicts 3-month functional outcome in patients with non-fatal hypertensive putaminal or thalamic hemorrhage2018

    • Author(s)
      Kojima D, Komoribayashi N, Omama S, Oikawa K, Fujiwara S, Kobayashi M, Kubo Y, Terasaki K, Ogasawara K
    • Journal Title

      Clin Nucl Med

      Volume: 印刷中 Issue: 6 Pages: 396-401

    • DOI

      10.1097/rlu.0000000000002068

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Practical microscale one-pot radiosynthesis of 18F-labeled probes.2018

    • Author(s)
      Iwata R, Pascali C, Terasaki K, Ishikawa Y, Furumoto S, Yanai K.
    • Journal Title

      J Label Compd Radiopharm

      Volume: 17 Issue: 7 Pages: 1-10

    • DOI

      10.1002/jlcr.3618

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Preoperatively reduced cerebrovascular contractile reactivity to hypocapnia by hyperventilation is associated with cerebral hyperperfusion syndrome after arterial bypass surgery for adult patients with cerebral misery perfusion due to ischemic moyamoya disease.2018

    • Author(s)
      Sato S, Kojima D, Shimada Y, Yoshida J, Fujimato K, Fujiwara S, Kobayashi M, Kubo Y, Yoshida K, Terasaki K, Tsutsui S, Miyoshi K, Ogasawara K.
    • Journal Title

      J Cereb Blood Flow Metab

      Volume: 1 Issue: 6 Pages: 1021-1031

    • DOI

      10.1177/0271678x18757621

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Minimization of the amount of Kryptofix 222-KHCO3 for applications to microscale 18F-radiolabeling.2017

    • Author(s)
      Iwata R, Pascali C, Terasaki K, Ishikawa Y, Furumoto S, Yanai K
    • Journal Title

      Appl Radiat Isot

      Volume: 125 Pages: 113-118

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Apparent brain temperature imaging with multi-voxel proton magnetic resonance spectroscopy compared with cerebral blood flow and metabolism imaging on positron emission tomography in patients with unilateral chronic major cerebral artery steno-occlusive disease2017

    • Author(s)
      Nanba T, Nishimoto H, Yoshioka Y, Murakami T, Sasaki M, Uwano I, Fujiwara S, Terasaki K, Ogasawara K
    • Journal Title

      Neuroradiology

      Volume: 59 Issue: 9 Pages: 923-935

    • DOI

      10.1007/s00234-017-1890-3

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] A concentration method for efficient microscale one-pot radiosynthesis of [18F]FET and [18F]fallypride.2019

    • Author(s)
      Iwata R, Harada R, Terasaki K, Ishikawa Y, Yanai K.
    • Organizer
      23rd International Symposium on Radiopharmaceutical Sciences
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Feasibility of using apparent brain temperature map on proton magnetic resonance spectroscopy to detect hemodynamic abnormalities in patients with unilateral chronic major cerebral artery steno-occlusive disease.2019

    • Author(s)
      Namba T, Ogasawara K, Yoshioka Y, Sasaki M, Uwano I, Ishigaki D, Kobayashi M, Yoshida K, Fujiwara, Terasaki K.
    • Organizer
      10th Annual Scientific Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relation between reduction of hypoxic tissue and cognitive improvement after revascularization surgery in patients with chronic cerebral ischemia.2019

    • Author(s)
      Shimada Y, Kobayashi M, Yoshida K, Terasaki K, Fujiwara S, Kubo Y, Beppu T, Ogasawara K.
    • Organizer
      5th European Stroke Organisation Conference 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Crossed cerebellar tracer uptake on acute-stage 123I-iomazenil SPECT imaging predicts 3-month functional outcome in patients with non-fatal hypertensive putaminal or thalamic hemorrhage.2019

    • Author(s)
      Kojima D, Komoribayashi N, Omama S, Oikawa K, Fujiwara S, Kobayashi M, Kubo Y, Terasaki K, Ogasawara K.
    • Organizer
      BRAIN & BRAIN PET 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Feasibility of apparent brain temperature map by 1H-MRS to detect hemodynamic abnormality in patients with unilateral chronic major cerebral artery steno-occlusive disease.2019

    • Author(s)
      Namba T, Ogasawara K, Yoshioka Y, Sasaki M, Uwano I, Ishigaki D, Kobayashi M, Yoshida K, Fujiwara S, Terasaki K.
    • Organizer
      BRAIN & BRAIN PET 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 慢性脳虚血に対する血行再建術後の"低酸素環境下生存脳組織"の消失は認知機能改善と関連しているか?2019

    • Author(s)
      島田泰良, 小林正和, 吉田研二, 寺崎一典, 藤原俊朗, 久保慶高, 別府高明, 小笠原邦昭
    • Organizer
      STROKE 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Preoperative cerebral oxygen extraction fraction imaging generated from 7-tesla magnetic resonance quantitative susceptibility mapping predicts development of cerebral hyperperfusion following carotid endarterectomy.2018

    • Author(s)
      Nomura J, Uwano I, Sasaki M, Kudo K, Yamashita F, Ito K, Fujiwara S, Matsumoto Y, Oikawa K, Chida K, Terasaki K, Kobayashi M, Yoshida K, Ogasawara K.
    • Organizer
      the Joint Annual Meeting ISMRM-ESMRMB
    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 顎骨浸潤を伴う歯肉癌に対する18F-FDG集積の増大効果2018

    • Author(s)
      六本木 基, 小豆島正典、寺崎一典
    • Organizer
      第57回日本核医学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 急性期IMZ-SPECT上のcrossed cerebellar diaschisisは非致死的脳出血の機能転帰を予知する2018

    • Author(s)
      小島大吾、小守林靖一、大間々真一、及川公樹、藤原俊朗、小林正和、久保慶高、寺崎一典、小笠原邦昭
    • Organizer
      日本脳神経外科学会第77回学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] F-AV-45による脳アミロイド PETを施行したamnestic MCI、AD群の経過の検討2018

    • Author(s)
      佐藤光信、米澤久司、工藤雅子、柴田俊秀、小原智子、石塚直樹、高橋純子、寺山靖夫、佐々木敏秋、齋藤義弘、寺崎一典、世良耕一郎
    • Organizer
      第61回日本脳循環代謝学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 急性期IMZ-SPECT上のcrossed cerebellar diaschisisは非致死的脳出血の機能転帰を予知する2018

    • Author(s)
      小島大吾、小守林靖一、大間々真一、及川公樹、藤原俊朗、小林正和、久保慶高、寺崎一典、小笠原邦昭
    • Organizer
      第61回日本脳循環代謝学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Microscale radiosynthesis of 18F-labeled compounds.2017

    • Author(s)
      Iwata R, Pascali C, Terasaki K, Ishikawa Y, Furumoto S, Yanai
    • Organizer
      22nd International Symposium on Radiopharmaceutical Sciences 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Augmentation effects of lymphocyte activation by antigen-presenting macrophages on 18F-FDG uptake.2017

    • Author(s)
      Roppongi M, Shozushima M, Izumisawa M, Takahashi T, Terasaki K.
    • Organizer
      21st International Congress of Dental and Maxillo-Facial Radiology 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 顎骨浸潤を伴う歯肉癌に対する18F-FDG集積の増大効果2017

    • Author(s)
      六本木 基、 小豆島正典、寺崎一典
    • Organizer
      第57回日本核医学会学術総会
    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi