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Development of a novel low-dose digital breast tomosynthesis system applying compressed sensing: physics and clinical evaluation

Research Project

Project/Area Number 17K10373
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKitasato University

Principal Investigator

GOMI Tsutomu  北里大学, 医療衛生学部, 教授 (10458747)

Co-Investigator(Kenkyū-buntansha) 鯉淵 幸生  独立行政法人国立病院機構高崎総合医療センター(臨床研究部), 臨床研究部, 臨床研究部長 (10323346)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords乳がん / トモシンセシス / 被ばく線量低減 / 放射線 / 被ばく線量
Outline of Final Research Achievements

The mortality rate of breast cancer is on the rise, and it is necessary to develop a screening system that improves the detectability of lesions. In our research, we have developed a new digital breast tomosynthesis system, focusing on the image reconstruction algorithm using compressed sensing and unsharp masking in order to improve the detectability of lesions. As a result, it was possible to suggest that the detectability of lesions is improved and the radiation dose is reduced. Our research results will improve the detectability of lesions and reduce the radiation dose, and we would like to develop them for future clinical applications.

Academic Significance and Societal Importance of the Research Achievements

新たな乳腺デジタルトモシンセシスシステムの開発によって高い病変検出能を有したスライス画像の提供と被ばく線量の低減を示唆したことから、臨床用途としての可能性を示したといえる。さらに、微細病変の検出能向上を実現する検診等のスクリーニング目的で活用できることが期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (9 results)

All 2020 2019 2018 2017

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (3 results) (of which Int'l Joint Research: 3 results) Book (2 results)

  • [Journal Article] Development of a denoising convolutional neural network-based algorithm for metal artifact reduction in digital tomosynthesis for arthroplasty: A phantom study2019

    • Author(s)
      Gomi Tsutomu、Sakai Rina、Hara Hidetake、Watanabe Yusuke、Mizukami Shinya
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 9 Pages: e0222406-e0222406

    • DOI

      10.1371/journal.pone.0222406

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Use of a total variation minimization iterative reconstruction algorithm to evaluate reduced projections during digital breast tomosynthesis.2018

    • Author(s)
      Tsutomu Gomi, Yukio Koibuchi
    • Journal Title

      Biomed Research International

      Volume: 2018 Pages: 1-14

    • DOI

      10.1155/2018/5239082

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a novel algorithm for metal artifact reduction in digital tomosynthesis using projection-based dual-energy material decomposition for arthroplasty: A phantom study.2018

    • Author(s)
      Tsutomu Gomi, Rina Sakai, Masami Goto, Hidetake Hara, Yusuke Watanabe
    • Journal Title

      Physica Medica: European Journal of Medical Physics

      Volume: 53 Pages: 4-16

    • DOI

      10.1016/j.ejmp.2018.07.011

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of digital tomosynthesis reconstruction algorithms used to reduce metal artifacts for arthroplasty: A phantom study2017

    • Author(s)
      Gomi Tsutomu、Sakai Rina、Goto Masami、Hara Hidetake、Watanabe Yusuke、Umeda Tokuo
    • Journal Title

      Physica Medica

      Volume: 42 Pages: 28-38

    • DOI

      10.1016/j.ejmp.2017.07.023

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Development of a novel denoising convolutional neural network-based algorithm for metal artifact reduction in digital tomosynthesis.2020

    • Author(s)
      Tsutomu Gomi, Hidetake Hara, Yusuke Watanabe, Shinya Mizukami
    • Organizer
      SPIE
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reduction of Metal Artifacts During Digital Tomosynthesis Reconstruction from Projection-Based Material Decomposition for Arthroplasty: A Phantom Study.2018

    • Author(s)
      Tsutomu Gomi, Masami Goto, Hidetake Hara, Yusuke Watanabe, Kazuaki Suwa
    • Organizer
      RSNA
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Potential Exposure Dose Reductions During Digital Breast Tomosynthesis Using a Novel Compressive Sensing Algorithm.2017

    • Author(s)
      Tsutomu Gomi, Akihiro Fujita, Masami Goto, Yusuke Watanabe, Tokuo Umeda, Akiko Okawa.
    • Organizer
      Radiological Society of North America (RSNA)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Book] Medical Imaging and Image-Guided Interventions2019

    • Author(s)
      Tsutomu Gomi
    • Total Pages
      86
    • Publisher
      IntechOpen
    • Related Report
      2019 Annual Research Report
  • [Book] 関節リウマチの画像診断2017

    • Author(s)
      杉本英治、神島保、五味 勉、中田和佳、河村太介、小野寺智洋、高畑雅彦、青木隆敏、寺澤 岳
    • Total Pages
      353
    • Publisher
      メディカル・サイエンス・インターナショナル
    • ISBN
      9784895928946
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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