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Research on composite deep learning network for AI-based clinical image diagnosis

Research Project

Project/Area Number 17K10385
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionNational Institutes for Quantum Science and Technology

Principal Investigator

Tachibana Yasuhiko  国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所 分子イメージング診断治療研究部, 主幹研究員 (20749973)

Co-Investigator(Kenkyū-buntansha) 相田 典子  地方独立行政法人神奈川県立病院機構神奈川県立こども医療センター(臨床研究所), 臨床研究所, 部長 (20586292)
Project Period (FY) 2017-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords画像診断 / 人工知能 / 深層学習 / 機械学習 / ディープラーニング / AI / 分類 / 画像処理 / 可視化 / 分類問題 / バイアス / アノテーション / 画像変換問題 / データバイアス / MRI / 脳 / ニューラルネットワーク / 分類学習 / 放射線 / 画像
Outline of Final Research Achievements

As an achievement directly related to the submitted research proposal, we developed an original method for visualizing the basis of judgment in AI diagnosis (image classification task), and published the results at domestic and international conferences and in scientific journals.
In addition, we have launched several new research projects based on the findings obtained through this project, and are continuing to promote these projects and publishing the achievements.

Academic Significance and Societal Importance of the Research Achievements

Iの説明性を高めるために用いられる一般的な手法では画像上の位置など、画像から得られる医学的情報とは無関係な情報のみを対象とするが、提案手法では解剖学など医学的な情報を加味できるメリットが今後役立つ可能性がある。つまり、画像診断についてAIが医師に提案をするとき、医師がその提案をどのように解釈すべきか、信用できるかどうかを判断するために、より具体的な医学的根拠を利用することができる可能性がある。

Report

(7 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (51 results)

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article (11 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 9 results,  Open Access: 8 results) Presentation (34 results) (of which Int'l Joint Research: 15 results,  Invited: 14 results) Book (2 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] Dual-Energy Computed Tomography-Based Iodine Concentration Estimation for Evaluating Choroidal Malignant Melanoma Response to Treatment: Optimization and Primary Validation2022

    • Author(s)
      Tsuchiya Hiroki, Tachibana Yasuhiko, Kishimoto Riwa, Omatsu Tokuhiko, Hotta Eika, Tanimoto Katsuyuki, Wakatsuki Masaru, Obata Takayuki, Tsuji Hiroshi
    • Journal Title

      Diagnostics

      Volume: 12 Issue: 11 Pages: 2692-2692

    • DOI

      10.3390/diagnostics12112692

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Super-resolution generative adversarial networks with static T2*WI-based subject-specific learning to improve spatial difference sensitivity in fMRI activation2022

    • Author(s)
      Ota J, Umehara K, Kershaw J, Kishimoto R, Hirano Y, Tachibana Y, Ohba H, Obata T
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 10319-10319

    • DOI

      10.1038/s41598-022-14421-5

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exploring cell membrane water exchange in aquaporin-4-deficient ischemic mouse brain using diffusion-weighted MRI.2021

    • Author(s)
      Urushihata Takuya, Takuwa Hiroyuki, Manami Takahashi, Tachibana Yasuhiko, Jeffrey Kershaw, Nitta Nobuhiro, Shibata Sayaka, Masato Yasui, Higuchi Makoto, Obata Takayuki
    • Journal Title

      European radiology experimental

      Volume: 44 Issue: 1 Pages: 44-44

    • DOI

      10.1186/s41747-021-00244-y

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Monte Carlo Simulator for Diffusion-weighted Imaging Sequences2021

    • Author(s)
      Yasuhiko Tachibana, Tanguy Duval, Takayuki Obata
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 20 Issue: 2 Pages: 222-226

    • DOI

      10.2463/mrms.bc.2020-0013

    • NAID

      130008046941

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Utility of a Convolutional Neural Network for Generating a Myelin Volume Index Map from Rapid Simultaneous Relaxometry Imaging2020

    • Author(s)
      Yasuhiko Tachibana, Akifumi Hagiwara, Masaaki Hori, Jeffrey Kershaw, Misaki Nakazawa, Tokuhiko Omatsu, Riwa Kishimoto, Kazumasa Yokoyama, Nobutaka Hattori, Shigeki Aoki, Tatsuya Higashi, Takayuki Obata
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 19 Issue: 4 Pages: 324-332

    • DOI

      10.2463/mrms.mp.2019-0075

    • NAID

      130007948910

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] New algorithm using L1 regularization for measuring electron energy spectra2020

    • Author(s)
      Hironao Sakaki, Tomohiro Yamashita, Akagi, Mamiko Nishiuchi, NicholasPeter Dover, HazelFrances Lowe, Kotaro Kondo, Akira Kon, Masaki Kando, Yasuhiko Tachibana, Takayuki Obata, Keiichiro Shiokawa, Tatsuhiko Miyatake, Yukinobu Watanabe
    • Journal Title

      Review of Scientific Instruments

      Volume: 91 Issue: 7

    • DOI

      10.1063/1.5144897

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multiple sclerosis lesions in motor tracts from brain to cervical cord: spatial distribution and correlation with disability2020

    • Author(s)
      Anne Kerbrat, Charley Gros, Atef Badji, Elise Bannier, Francesca Galassi, Benoit Combes, Raphael Chouteau, Pierre Labauge, Xavier Ayrignac, Yasuhiko Tachibana, Others
    • Journal Title

      Brain

      Volume: 143 Issue: 7 Pages: 2089-2105

    • DOI

      10.1093/brain/awaa162

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A neural network model that learns differences in diagnosis strategies among radiologists has an improved area under the curve for aneurysm status classification in magnetic resonance angiography image series2020

    • Author(s)
      Yasuhiko Tachibana, Masataka Nishimori, Naoyuki Kitamura, Kensuke Umehara, Junko Ota, Takayuki Obata, Tatsuya Higashi
    • Journal Title

      arXiv

      Volume: epub

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Open Access
  • [Journal Article] The Utility of Applying Various Image Preprocessing Strategies to Reduce the Ambiguity in Deep Learning-based Clinical Image Diagnosis2020

    • Author(s)
      Tachibana Yasuhiko、Obata Takayuki、Kershaw Jeff、Sakaki Hironao、Urushihata Takuya、Omatsu Tokuhiko、Kishimoto Riwa、Higashi Tatsuya
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 19 Issue: 2 Pages: 92-98

    • DOI

      10.2463/mrms.mp.2019-0021

    • NAID

      130007839525

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improving the Quality of Synthetic FLAIR Images with Deep Learning Using a Conditional Generative Adversarial Network for Pixel-by-Pixel Image Translation2019

    • Author(s)
      Hagiwara A.、Otsuka Y.、Hori M.、Tachibana Y.、Yokoyama K.、Fujita S.、Andica C.、Kamagata K.、Irie R.、Koshino S.、Maekawa T.、Chougar L.、Wada A.、Takemura M.Y.、Hattori N.、Aoki S.
    • Journal Title

      American Journal of Neuroradiology

      Volume: 40 Issue: 2 Pages: 224-230

    • DOI

      10.3174/ajnr.a5927

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The utility of a convolutional neural network for generating a myelin volume index map from rapid simultaneous relaxometry imaging2019

    • Author(s)
      Yasuhiko Tachibana, Akifumi Hagiwara, Masaaki Hori, Jeff Kershaw, Misaki Nakazawa, Tokuhiko Omatsu, Riwa Kishimoto, Kazumasa Yokoyama, Nobutaka Hattori, Shigeki Aoki, Tatsuya Higashi, Takayuki Obata
    • Journal Title

      arXiv

      Volume: arXiv:1904.10960

    • NAID

      130007948910

    • Related Report
      2018 Research-status Report
    • Open Access
  • [Presentation] MRI画像診断の実態とAI応用2023

    • Author(s)
      立花 泰彦
    • Organizer
      総理工情報科学セミナー
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 放射線照射腫瘍モデルマウスの低酸素領域の描出におけるMRI の有用性の検討2022

    • Author(s)
      今泉 晶子, 平山 亮一, 長谷川 純崇, Kershaw Jeffrey, 立花 泰彦, 柴田 さやか, 新田 展大, 鵜澤 玲子, 東 達也, 小畠 隆行
    • Organizer
      第50回日本磁気共鳴医学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 乳腺ダイナミック造影MRIにおける血行動態の簡易指標マッピングと汎用ソフトウェア開発2022

    • Author(s)
      生駒 洋子, 尾松 徳彦, 岸本 理和, 立花 泰彦, 小畠 隆行
    • Organizer
      第50回日本磁気共鳴医学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] The usefulness of 4D convolution in deep-learning-based noise reduction for low-SNR body DWI2022

    • Author(s)
      Tachibana Yasuhiko, Tsuchiya Hiroki, Kishimoto Riwa, Omatsu Tokuhiko, Mori Shinichiro, Obata Takayuki, Higashi Tatsuya
    • Organizer
      ISMRM annual meeting 2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] 画像解析のすすめ 臨床応用・ピットフォール・気を付けるべき点2022

    • Author(s)
      立花 泰彦
    • Organizer
      第50回日本磁気共鳴医学会大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] The usefulness of 4D convolution in deep learning-based noise reduction for low-SNR body DWI2022

    • Author(s)
      Yasuhiko Tachibana, Hiroki Tsuchiya, Riwa Kishimoto, Tokuhiko Omatsu, Shinichiro Mori, Takayuki Obata, and Tatsuya Higashi
    • Organizer
      ISMRM 2022
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Exploring the effect of aquaporin-4 suppression on cell membrane water exchange in a mouse model of brain ischemia using diffusion-weighted MRI2021

    • Author(s)
      Urushihata Takuya, Takuwa Hiroyuki, Manami Takahashi, Tachibana Yasuhiko, Jeffrey Kershaw, Nitta Nobuhiro, Shibata Sayaka, Masato Yasui, Higuchi Makoto, Obata Takayuki
    • Organizer
      ISMRM 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 拡散強調MRIによる腫瘍モデルマウスの低酸素領域の検出2021

    • Author(s)
      今泉 晶子, 小畠 隆行, Kershaw Jeffrey, 立花 泰彦, 柴田 さやか, 新田 展大, 長谷川 純崇, 東 達也
    • Organizer
      第49回日本磁気共鳴医学会大会
    • Related Report
      2021 Research-status Report
  • [Presentation] instabilityを除いた深層学習によるノイズ低減法の評価2021

    • Author(s)
      Hayato Nozaki, Yasuhiko Tachibana, Yujiro Otsuka, Wataru Uchida, Yuya Saito, Koji Kamagata
    • Organizer
      第49回日本磁気共鳴医学会大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Deep learning-based DWI Denoising method that suppressed the "instability" problem2021

    • Author(s)
      Hayato Nozaki, Tachibana Yasuhiko, Yujiro Otsuka, Wataru Uchida, Yuya Saito, Koji Kamagata, Shigeki Aoki
    • Organizer
      ISMRM 2021
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Image Classification and Label Inhomogeneity2021

    • Author(s)
      Yasuhiko Tachibana
    • Organizer
      ISMRM JPC 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Deep Learning in Diagnostic Radiology2021

    • Author(s)
      Yasuhiko Tachibana
    • Organizer
      Summer School for Molecular Biomedical Science and Engineering, Hokkaido University
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] The neural network model that can consider the inhomogeneity of the judgements between different annotators: implementation for MRA diagnosis2020

    • Author(s)
      Yasuhiko Tachibana, Masataka Nishimori, Naoyuki Kitamura, Kensuke Umehara, Junko Ota, Takayuki Obata, and Tatsuya Higashi
    • Organizer
      ISMRM 2020
    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Deep-Brain: A Cutting-edge Concept for Outstanding Functional Resolution in fMRI2020

    • Author(s)
      Junko Ota, Kensuke Umehara, Yasuhiko Tachibana, Yoshiyuki Hirano, Hisateru Ohba, Takayuki Obata, Tatsuya Higashi
    • Organizer
      RSNA2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 医用画像+ディープラーニングな臨床研究をデザインするために知っておきたいこと2020

    • Author(s)
      立花 泰彦
    • Organizer
      第48回日本磁気共鳴医学会大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Radiological application of Deep learning: what the radiologists need to know ?2019

    • Author(s)
      Yasuhiko Tachibana
    • Organizer
      Neuroimaging summit 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] How to design an imaging research using deep learning? A beginner's guide2019

    • Author(s)
      Yasuhiko Tachibana
    • Organizer
      NeuroImaging Summit 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Deep learning in diagnostic imaging2019

    • Author(s)
      Yasuhiko Tachibana
    • Organizer
      MRI アライアンス 第4回国際シンポジウム
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 医用画像へのディープラーニング応用2019

    • Author(s)
      立花 泰彦
    • Organizer
      第30回CCSEワークショップ
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] A convolutional neural network-based approach for generating PET/CT image series in shorter scan time: A feasibility study2019

    • Author(s)
      Ritu Bhusal Chhatkuli, Yasuhiko Tachibana, Takayuki Obata, Yuto Kamitaka, Ryuichi Nishii, Tatsuya Higashi
    • Organizer
      第117回日本医学物理学会学術大会
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] ディープラーニングを用いた課題時fMRIの高精度化に向けた初期的検討2019

    • Author(s)
      大田 淳子, 立花 泰彦, 平野 好幸, 梅原 健輔, 影山 肇, 生駒 洋子, 大場 久照, 小畠 隆行
    • Organizer
      第47回日本放射線技術学会秋季学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] The utility of a convolutional neural network for generating a myelin volume index map from rapid simultaneous relaxometry imaging2019

    • Author(s)
      Yasuhiko Tachibana, Akifumi Hagiwara, Masaaki Hori, Jeffrey Kershaw, Misaki Nakazawa, Tokuhiko Omatsu, Riwa Kishimoto, Shigeki Aoki, Tatsuya Higashi, Takayuki Obata
    • Organizer
      ISMRM2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Improving the Quality of Synthetic FLAIR Images with Deep Learning Using a Conditional Generative Adversarial Network for Pixel-by-Pixel Image Translation2019

    • Author(s)
      Akifumi Hagiwara, Yasuhiko Tachibana, Shigeki Aoki
    • Organizer
      ISMRM2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Spatial distribution of multiple sclerosis lesions along the brain and spinal motor tracts and correlation with functional deficits2019

    • Author(s)
      Anne Kerbrat, Yasuhiko Tachibana, Julien Cohen-Adad
    • Organizer
      ISMRM2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] T2*WIを代替訓練データとして安静時fMRIを深層学習により高解像度化する手法の初期検討2019

    • Author(s)
      影山 肇, 立花 泰彦, 大田 淳子, 梅原 健輔, 平野 好幸, 小畠 隆行, 近藤 啓介, 志村 一男
    • Organizer
      第47回日本磁気共鳴医学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] The utility of a convolutional neural network for generating a myelin volume index map from rapid simultaneous relaxometry imaging2019

    • Author(s)
      Yasuhiko Tachibana, Akifumi Hagiwara, Masaaki Hori, Jeff Kershaw, Misaki Nakazawa, Tokuhiko Omatsu, Riwa Kishimoto, Kazumasa Yokoyama, Nobutaka Hattori, Shigeki Aoki, Tatsuya Higashi, Takayuki Obata
    • Organizer
      ISMRM2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 医用画像へのディープラーニング応用2019

    • Author(s)
      立花泰彦
    • Organizer
      第30回JAEA CCSEワークショップ
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 拡散強調像とDeep Learning2018

    • Author(s)
      立花泰彦
    • Organizer
      第46回日本磁気共鳴医学会大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 医用画像に深層学習をどう使うか2018

    • Author(s)
      立花泰彦
    • Organizer
      医用放射線技術研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] これでわかるはず、画像のためのディープラーニング入門2018

    • Author(s)
      立花泰彦
    • Organizer
      第1回日本医用画像人工知能研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Synthetic MRIを利用したミエリンマップ推定における畳み込みニューラルネットワークの有用性2018

    • Author(s)
      立花泰彦, 萩原彰文, 堀正明, 中澤美咲, 尾松徳彦, 岸本理和, 青木茂樹, 東達也, 小畠隆行
    • Organizer
      第46回日本磁気共鳴医学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Deep learning を利用した画像分類において学習精度と判断過程の可視化を両立する手法の検討2017

    • Author(s)
      立花泰彦、小畠隆行、漆畑拓弥、尾松徳彦、岸本利和、東達也
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 医療画像を深層ニューラルネットワークに用いるために有用な前処置ソフトウェアの開発2017

    • Author(s)
      立花泰彦、小畠隆行、漆畑拓弥、生駒洋子、尾松徳彦、岸本利和、東達也
    • Organizer
      第36回日本医用画像工学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Deep-Neural-Network based image diagnosis: comparing various image preprocessing2017

    • Author(s)
      Y. Tachibana, T. Obata, J. Kershaw, Y. Ikoma, R. Kishimoto, T. Omatsu, T. Higashi
    • Organizer
      ISMRM 2016 2016 Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Book] 脊髄脊椎ジャーナル Vol.35 No.102023

    • Author(s)
      立花泰彦
    • Total Pages
      8
    • Publisher
      三輪書店
    • Related Report
      2022 Annual Research Report
  • [Book] INNERVISION 2017年9月号2017

    • Author(s)
      立花泰彦
    • Total Pages
      3
    • Publisher
      株式会社インナービジョン
    • Related Report
      2017 Research-status Report
  • [Patent(Industrial Property Rights)] 情報処理装置、情報処理方法、情報処理プログラム、及び、記録媒体2023

    • Inventor(s)
      立花泰彦、橋本綾斗、岸本理和、森慎一郎
    • Industrial Property Rights Holder
      量子科学技術研究開発機構
    • Industrial Property Rights Type
      実用新案
    • Filing Date
      2023
    • Related Report
      2022 Annual Research Report
  • [Patent(Industrial Property Rights)] 画像診断装置、画像診断方法、画像診断プログラム、及び、記録媒体2022

    • Inventor(s)
      立花 泰彦
    • Industrial Property Rights Holder
      量子科学技術研究開発機構
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Related Report
      2021 Research-status Report
  • [Patent(Industrial Property Rights)] ノイズ除去装置、ノイズ除去方法、機械学習装置 、機械学習方法及びプログラム2021

    • Inventor(s)
      立花 泰彦, 大塚 裕次朗, 鎌形 康司
    • Industrial Property Rights Holder
      量子科学技術研究開発機構、順天堂大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2021 Research-status Report
  • [Patent(Industrial Property Rights)] ノイズ除去装置、ノイズ除去方法、機械学習装置、機械学習方法及びプログラム2021

    • Inventor(s)
      立花泰彦、大塚裕次朗
    • Industrial Property Rights Holder
      量子科学技術研究開発機構、順天堂大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2020 Research-status Report

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Published: 2017-04-28   Modified: 2024-01-30  

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