Development of PET imaging for the ischemic brain injury using novel acetate analog
| Project/Area Number |
17K10388
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Research Institute, Shiga Medical Center |
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Principal Investigator |
KAGAWA SHINYA 滋賀県立総合病院(研究所), 画像研究部門, 主任研究員 (10393191)
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| Co-Investigator(Kenkyū-buntansha) |
東 達也 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 分子イメージング診断治療研究部, 部長(定常) (50324629)
西井 龍一 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 分子イメージング診断治療研究部, 主幹研究員(定常) (60463212)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | フルオロ酢酸 / [18F]FACE / Methyl [18F]FACE / Ethyl [18F]FACE / 虚血性脳血管障害 / PET / 脳虚血 / 脳血管障害 / FACE / Methyl FACE |
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| Outline of Final Research Achievements |
This study aimed to develop radiosynthetic methods of [18F]Fluoroacetate ([18F]FACE) derivatives, Methyl [18F]Face, Ethyl [18F]Face and Benzyl [18F]FACE, which are supposed to have enhanced transferability to the brain and retention to the damaged area in order to pursue a new diagnostic imaging tracer evaluating ischemic brain injury. Among these, Methyl [18F]FACE showed the highest in-vivo stability, so we evaluated the utility of Methyl [18F]FACE using experimental rats settled under a transient cerebral ischemia by MCA occlusion and reperfusion state. Methyl [18F]FACE showed apparently higher accumulated in the ischemic region during MCA occlusion than in the contralateral healthy side. It was suggested that Methyl [18F]FACE is an optimal tracer for imaging of brain ischemia.
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| Academic Significance and Societal Importance of the Research Achievements |
脳血管障害の重症度評価、治療方針の決定、治療効果判定などの目的で使用される[15O]ガス ([15O]CO、[15O]O2、[15O]CO2)は、検査を行えるPET施設が少なく、動脈採血を基本とする非侵襲的な検査である。一方、新規に開発した18F標識新規酢酸誘導体は、半減期が長く実用的で検査数を増やすことが可能となり、将来的には、現在よりも質の高い脳核医学PET検査が広く一般診療で利用されるようになると期待される。
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Report
(5 results)
Research Products
(24 results)
