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Prediction of treatment effect using radiomics analysis with MRI for individual treatment of breast cancer

Research Project

Project/Area Number 17K10389
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionHokkaido University

Principal Investigator

Kato Fumi  北海道大学, 大学病院, 助教 (80399865)

Co-Investigator(Kenkyū-buntansha) 山下 啓子  北海道大学, 大学病院, 教授 (70332947)
ワン ジェフリー  北海道大学, 国際連携研究教育局, 博士研究員 (80754829)
馬場 基  独立行政法人国立病院機構北海道がんセンター(臨床研究部), 臨床研究部, 乳腺外科医師 (90724980)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords乳癌 / MRI / 術前化学療法
Outline of Final Research Achievements

We analyzed breast MRI findings of breast cancer patients who had received neoadjuvant chemotherapy (NAC) to develop a model predicting treatment effect using MRI. Differences were seen in mass size, kinetic pattern in dynamic contrast enhanced image, ADC value of diffusion weighted image and K value of diffusion kurtosis image at midpoint of NAC between a pathological complete response (pCR) group and a non-pCR group. Differences were also seen in amount and/or rate of these changes between pre and midpoint NAC. K value of pre-NAC MRI of the pCR group was significantly higher than that of the non-pCR group in hormone receptor negative-HER2 positive breast cancers, which is the subtype having the highest pCR rate.
We also investigated the relationship between ADC value and axillary lymph node (LN) metastasis, which is an important prognostic factor in luminal A-like breast cancer. ADC values of breast lesions with positive LN were significantly lower than those with negative LN.

Academic Significance and Societal Importance of the Research Achievements

乳癌の術前化学療法の治療効果を、MRIを用いて治療終了前に予測できれば、治療を継続するかどうかの判断を非侵襲的に行うことができる。さらに治療前に効果を予測することができれば、より適切な治療を選択可能となる。術前化学療法の効果は予後とも関連するため、治療効果の予測は予後の予測にも繋がる。
ルミナルA乳癌は最も予後良好なサブタイプであるため、術後や治療後の生活の質を保つことも重要である。MRIで非侵襲的にリンパ節転移がないことを術前に評価することにより、センチネルリンパ節生検も省略可能となり得るため、より侵襲度を低くすることが可能となる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (5 results)

All 2019 2018

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Predicting metastasis in clinically negative axillary lymph nodes with minimum apparent diffusion coefficient value in luminal A-like breast cancer.2019

    • Author(s)
      Kato F, Kudo K, Yamashita H, Baba M, Shimizu A, Oyama-Manabe N, Kinoshita R, Li R, Shirato H
    • Journal Title

      Breast Cancer

      Volume: 印刷中 Issue: 5 Pages: 628-636

    • DOI

      10.1007/s12282-019-00969-0

    • NAID

      120006882079

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 乳癌の術前化学療法の治療効果評価における拡散強調像および拡散尖度画像の有用性の検討2019

    • Author(s)
      加藤扶美、山下啓子、馬場 基、Wang J、真鍋徳子、工藤與亮
    • Organizer
      第27回日本乳癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Evaluation of Axillary Lymph Node Status using Minimum ADC of Breast Lesions in Luminal A-like Cancer with Clinically Negative Nodes2019

    • Author(s)
      Kato F, Kudo K, Yamashita H, Baba M, Shimizu A, Manabe N, Shirato H
    • Organizer
      ARRS (American Roentgen Ray Society) annual meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 3T乳腺MRIを用いた乳癌の術前化学療法の治療効果予測に関する検討2018

    • Author(s)
      加藤扶美、山下啓子、馬場 基、石田直子、真鍋徳子、工藤與亮
    • Organizer
      第26回日本乳癌学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 臨床的転移陰性luminal A-like乳癌における原発巣の最小ADC値による腋窩リンパ節転移評価2018

    • Author(s)
      加藤扶美、工藤與亮、山下啓子、馬場基、清水亜衣、真鍋徳子、白土博樹
    • Organizer
      第77回日本医学放射線学会総会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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