Development of new liver tumor diagnostic method using Gd-EOB-DTPA and ICG

• Project/Area Number: 17K10393
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: The University of Tokyo
• Principal Investigator: Akai Hiroyuki 東京大学, 医科学研究所, 准教授 (80770437)
• Co-Investigator(Kenkyū-buntansha): 桐生 茂 国際医療福祉大学, 医学部, 教授 (20313124)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: ガドリニウム造影剤 / MRI / 肝細胞癌 / 肝転移 / 肝臓 / 放射線科学 / 核磁気共鳴画像

Outline of Final Research Achievements

In this study, we attempted to develop a new liver tumor diagnostic method using Gd-EOB-DTPA (hereinafter referred to as EOB) and ICG. Although, the effect of ICG administration on the inhibition of EOB uptake into the liver was stronger than expected. So, the development of an administration method useful for differentiating liver tumors was not realized.
We published multiple sub-papers, and found that ICG inhibits EOB liver accumulation and excretion (Invest Radiol 2017:441-5), and that EOB causes transient tachypnea (Eur Radiol 2018:4128-33), and that gadolinium brain deposition does not affect mouse movement or behavior (Radiology 2021:409-16).

Academic Significance and Societal Importance of the Research Achievements

Gd-EOB-DTPAの基礎的な検討を通して、同造影剤の臨床応用の一助となったと考えられる。
また、ガドリニウムの脳沈着はガドリニウム造影剤の安全性を考え上で重要な懸念となるが、少なくともマウスにおいては運動や行動に影響を及ぼさないことが確認されたことで、ガドリニウム造影剤の安全性に関する新たな治験が積み重なったと考えられる。

Research Products

• [Journal Article] Effects of Gadolinium Deposition in the Brain on Motor or Behavioral Function: A Mouse Model (2021)
  • Author(s): Akai H, Miyagawa K, Takahashi K, Mochida-Saito A, Kurokawa K, Takeda H, Tsuji M, Sugawara H, Yasaka K, Kunimatsu A, Inoue Y, Abe O, Ohtomo K, Kiryu S.
  • Journal Title: Radiology Volume: 301 Issue: 2 Pages: 409-416
  • DOI: 10.1148/radiol.2021210892
  • Peer Reviewed
• [Journal Article] The inhibitory effect of gadoxetate disodium on hepatic transporters: a study using indocyanine green (2018)
  • Author(s): Akai Hiroyuki、Yasaka Koichiro、Kunimatsu Akira、Nojima Masanori、Inoue Yusuke、Abe Osamu、Ohtomo Kuni、Kiryu Shigeru
  • Journal Title: European Radiology Volume: 28 Issue: 10 Pages: 4128-4133
  • DOI: 10.1007/s00330-018-5403-5
  • Peer Reviewed
• [Journal Article] Gadoxetate disodium-induced tachypnoea and the effect of dilution method: a proof-of-concept study in mice (2017)
  • Author(s): Akai Hiroyuki、Yasaka Koichiro、Nojima Masanori、Kunimatsu Akira、Inoue Yusuke、Abe Osamu、Ohtomo Kuni、Kiryu Shigeru
  • Journal Title: European Radiology Volume: 28 Issue: 2 Pages: 692-697
  • DOI: 10.1007/s00330-017-5037-z
  • Peer Reviewed
• [Presentation] Gd造影剤の呼吸に対する急性期の影響に関する検討 (2018)
  • Author(s): 赤井宏行、八坂耕一郎、國松聡、井上優介、阿部修、大友邦、桐生茂
  • Organizer: 第46回日本磁気共鳴医学会大会
• [Presentation] Indocyanine Greenを用いたGd-EOB-DTPAの肝トランスポーターへの影響の検討 (2018)
  • Author(s): 赤井宏行、桐生茂、八坂耕一郎、國松聡、井上優介、大友邦、阿部修
  • Organizer: 第13回日本分子イメージング学会総会・学術集会