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Development of arterial spin labeling MRI for obstetric disease

Research Project

Project/Area Number 17K10395
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionUniversity of Fukui

Principal Investigator

KOSAKA NOBUYUKI  福井大学, 学術研究院医学系部門, 准教授 (60397247)

Co-Investigator(Kenkyū-buntansha) 木村 浩彦  福井大学, 学術研究院医学系部門, 教授 (10242596)
黒川 哲司  福井大学, 学術研究院医学系部門, 准教授 (60334835)
金本 雅行  福井大学, 学術研究院医学系部門(附属病院部), 診療放射線技師 (60730728)
藤原 康博  熊本大学, 大学院生命科学研究部(保), 准教授 (90422675)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsMRI / 灌流画像 / 子宮 / 腎臓 / Arterial spin labeling / arterial spin labeling / 放射線
Outline of Final Research Achievements

In this research, we applied arterial spin labeling MRI (ASL-MRI), a kind of non-contrast enhanced perfusion-weighted MRI to abdominal organs, especially to uterus. ASL-MRI demonstrated results equivalent to those of dynamic contrast-enhanced MRI in the patient with retained products of conception. Furthermore, we developed abdominal ASL-MRI sequence by employing new techniques, such as Hadamard encoding. This new ASL-MRI sequence is expected to improve image quality as well as to shorten scanning time. We are planning to apply this to following clinical abdominal ASL-MRI researches.

Academic Significance and Societal Importance of the Research Achievements

今回の研究成果では、造影剤を用いない新しいMRI撮像法を出産後の合併症である遺残胎盤に用い、造影剤を使用する検査と同等の結果を示すことができた。このことは、造影剤使用における副作用を避けることができ、また医療コストの低減につながると考えている。また、新たな技術を用い腹部臓器用ASL撮像法の改良を行った。この新しいASL撮像法は、今後の臨床研究において画質の向上のみならず、撮像時間の短縮に寄与できると考えている。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (2 results)

All 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Evaluation of retained products of conception using pulsed continuous arterial spin-labeling MRI: clinical feasibility and initial results2018

    • Author(s)
      Kosaka Nobuyuki、Fujiwara Yasuhiro、Kurokawa Tetsuji、Matsuda Tsuyoshi、Kanamoto Masayuki、Takei Naoyuki、Takata Kenji、Takahashi Jin、Yoshida Yoshio、Kimura Hirohiko
    • Journal Title

      Magnetic Resonance Materials in Physics, Biology and Medicine

      Volume: - Issue: 4 Pages: 577-584

    • DOI

      10.1007/s10334-018-0681-0

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 骨盤内女性臓器疾患における機能イメージングの可能性:ASLの子宮への臨床応用2017

    • Author(s)
      小坂信之、木村浩彦
    • Journal Title

      インナービジョン

      Volume: 32(8) Pages: 56-58

    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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