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Evaluation of glymphatic system in the human brain using diffusion MR images and application to Alzheimer's disease.

Research Project

Project/Area Number 17K10397
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionNagoya University

Principal Investigator

Taoka Toshiaki  名古屋大学, 医学系研究科, 特任教授 (30305734)

Co-Investigator(Kenkyū-buntansha) 長縄 慎二  名古屋大学, 医学系研究科, 教授 (50242863)
増谷 佳孝  広島市立大学, 情報科学研究科, 教授 (20345193)
安野 史彦  国立研究開発法人国立長寿医療研究センター, 病院, 医長 (60373388)
川井 恒  名古屋大学, 医学部附属病院, 講師 (50378147)
岸本 年史  奈良県立医科大学, 医学部, 教授 (60201456)
吉川 公彦  奈良県立医科大学, 医学部, 教授 (10161506)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsGlymphatic system / 拡散画像 / MRI / 脳・神経 / 核磁気共鳴画像 / Glymphaticシステム
Outline of Final Research Achievements

In the current study, we hypothesized that diffusivity limited to the direction of perivascular space correlates with activity of the Glymphatic system. We developed a method called "diffusion tensor image analysis along the perivascular space (DTI-ALPS)" as a method to evaluate the movement of water molecules in deep white matter from diffusion tensor images. In this method, the diffusivity in the perivascular space in the white matter outside the lateral ventricle was evaluated using the ratio to the diffusivity in the orthogonal direction(ALPS index). In the evaluation of Alzheimer's disease cases, the ALPS index was significantly inversely correlated with the MMSE score. This suggests that the ALPS index may be an index that reflects the function of the Glymphatic system.

Academic Significance and Societal Importance of the Research Achievements

グリンパティック系の障害は、アルツハイマー病の発症にいたる異常蛋白の蓄積の機序に関連すると考えられている。グリンパティック系の評価を拡散画像で非侵襲的に行うことができれば、アミロイドイメージング等で確認できるよりも早期の、新たな概念に基づいた発症機序の解明が可能となりうることから、予防・治療薬の創薬研究の基礎ともなりうる。また、適切な生活習慣によってアルツハイマー病の予防を行うことが可能となる事も考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report

Research Products

(41 results)

All 2020 2019 2018 2017

All Journal Article Presentation Book

  • [Journal Article] Comprehensive Evaluation of B<sub>1</sub><sup>+</sup>-corrected FISP-based Magnetic Resonance Fingerprinting: Accuracy, Repeatability and Reproducibility of T<sub>1</sub> and T<sub>2</sub> Relaxation Times for ISMRM/NIST System Phantom and Volunteers2020

    • Author(s)
      Yutaka Kato, Kazushige Ichikawa, Kuniyasu Okudaira, Toshiaki Taoka, Hirokazu Kawaguchi, Katsutoshi Murata, Katsuya Maruyama, Gregor Koerzdoerfer, Josef Pfeuffer, Mathias Nittka, Shinji Naganawa
    • Journal Title

      MRMS

      Volume: - Issue: 3 Pages: 168-175

    • DOI

      10.2463/mrms.mp.2019-0016

    • NAID

      130007665493

    • ISSN
      1347-3182, 1880-2206
    • Year and Date
      2020-08-03
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Detection of IV-gadolinium Leakage from the Cortical Veins into the CSF Using MR Fingerprinting2020

    • Author(s)
      Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka, Hirokazu Kawaguchi, Katsuya Maruyama, Katsutoshi Murata, Gregor Korzdorfer, Josef Pfeuffer, Mathias Nittka, Michihiko Sone
    • Journal Title

      MRMS

      Volume: - Issue: 2 Pages: 141-146

    • DOI

      10.2463/mrms.mp.2019-0048

    • NAID

      130007665494

    • ISSN
      1347-3182, 1880-2206
    • Year and Date
      2020-05-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glymphatic imaging using MRI2020

    • Author(s)
      Toshiaki Taoka, Shinji Naganawa
    • Journal Title

      Journal of Magnetic Resonance Imaging

      Volume: 51(1) Pages: 11-24

    • DOI

      10.1002/jmri.26892

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Space between the Pial Sheath and the Cortical Venous Wall May Connect to the Meningeal Lymphatics2020

    • Author(s)
      Shinji Naganawa, Rintaro Ito, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone
    • Journal Title

      MRMS

      Volume: 19(1) Issue: 1 Pages: 1-4

    • DOI

      10.2463/mrms.bc.2019-0099

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] White matter microstructural changes in tuberous sclerosis: Evaluation by neurite orientation dispersion and density imaging (NODDI) and diffusion tensor images2020

    • Author(s)
      Toshiaki Taoka, Noriko Aida, Yuta Fujii, Kazushi Ichikawa, Hisashi Kawai, Toshiki Nakane, Rintaro Ito, Shinji Naganawa
    • Journal Title

      Scientific Reports

      Volume: 10 Pages: 436-436

    • DOI

      10.1038/s41598-019-57306-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Confirmation of Age-dependence in the Leakage of Contrast Medium around the Cortical Veins into Cerebrospinal Fluid after Intravenous Administration of Gadolinium-based Contrast Agent2020

    • Author(s)
      Shinji Naganawa, Rintaro Ito, Hisashi Kawai, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone
    • Journal Title

      MRMS

      Volume: - Issue: 4 Pages: 375-381

    • DOI

      10.2463/mrms.mp.2019-0182

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age Dependence of Gadolinium Leakage from the Cortical Veins into the Cerebrospinal Fluid Assessed with Whole Brain 3D-real Inversion Recovery MR Imaging2019

    • Author(s)
      Naganawa S, Nakane T, Kawai H, Taoka T.
    • Journal Title

      MRMS

      Volume: 18 Issue: 2 Pages: 163-169

    • DOI

      10.2463/mrms.mp.2018-0053

    • NAID

      130007630075

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Can low b value difusion weighted imaging evaluate the character of cerebrospinal luid dynamics?2019

    • Author(s)
      Taoka, T; Naganawa, S; Kawai, H; Nakane, T; Murata, K
    • Journal Title

      Japanese Journal of Radiology

      Volume: 37 Pages: 135-144

    • DOI

      10.1007/s11604-018-0790-8

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inter-individual Comparison of Gadobutrol and Gadoteridol Tissue Time-intensity Profiles for Dynamic Susceptibility Contrast Perfusion MR Imaging2019

    • Author(s)
      Yamada, M; Taoka, T; Kawaguchi, A; Yasuda, K; Niinomi, Y; Ohashi, Y; Okuda, T; Naganawa, S
    • Journal Title

      MRMS

      Volume: 18 Issue: 1 Pages: 75-81

    • DOI

      10.2463/mrms.mp.2017-0172

    • NAID

      130006744018

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improved 3D-real Inversion Recovery: A Robust Imaging Technique for Endolymphatic Hydrops after Intravenous Administration of Gadolinium2019

    • Author(s)
      Shinji Naganawa, Hisashi Kawai, Toshiaki Taoka, Michihiko Sone
    • Journal Title

      MRMS

      Volume: - Issue: 1 Pages: 105-108

    • DOI

      10.2463/mrms.bc.2017-0158

    • NAID

      130006449199

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased signal intensity of low-concentration gadolinium contrast agent by longer repetition time in heavily T2 weighted ;FLAIR.2019

    • Author(s)
      Kato Y, Bokura K, Taoka T, Naganawa S.
    • Journal Title

      Jpn J Radiol

      Volume: 38 Pages: 431-435

    • DOI

      10.1007/s11604-019-00828-0

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gadolinium-based Contrast Media, Cerebrospinal Fluid and the Glymphatic System: Possible Mechanisms for the Deposition of Gadolinium in the Brain2018

    • Author(s)
      Toshiaki Taoka, Shinji Naganawa
    • Journal Title

      MRMS

      Volume: - Issue: 2 Pages: 111-119

    • DOI

      10.2463/mrms.rev.2017-0116

    • NAID

      130006685586

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of the Glymphatic System on the Kinetic and Distribution of Gadodiamide in the Rat Brain.2018

    • Author(s)
      Taoka Toshiaki、Jost Gregor、Frenzel Thomas、Naganawa Shinji、Pietsch Hubertus
    • Journal Title

      Invest Radiol.

      Volume: 53 Pages: 1-1

    • DOI

      10.1097/rli.0000000000000473

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] PREDICTION OF INTRACRANIAL ARTERIAL STENOSIS PROGRESSION IN PATIENTS WITH MOYAMOYA VASCULOPATHY: CONTRAST-ENHANCED HIGH-RESOLUTION MAGNETIC RESONANCE VESSELWALL IMAGING2018

    • Author(s)
      Muraoka, S; Araki, Y; Taoka, T; Kawai, H; Okamoto, S; Uda, K; Ota, S; Naganawa, S; Wakabayashi, T
    • Journal Title

      INTERNATIONAL JOURNAL OF STROKE

      Volume: 13 Pages: 32-32

    • DOI

      10.1183/13993003.congress-2018.pa707

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Corpus Callosal Involvement Is Correlated with Cognitive Impairment in Multiple System Atrophy2018

    • Author(s)
      Hara K, Watanabe H, Bagarinao E, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Tsuboi T, Ito M, Atsuta N, Niwa H, Taoka T, Maesawa S, Naganawa S, Katsuno M, Sobue G.
    • Journal Title

      J Neurol

      Volume: 265 Pages: 2079-2087

    • DOI

      10.1007/s00415-018-8923-7

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A guide to identification and selection of axial planes in magnetic resonance imaging of the brain2018

    • Author(s)
      Otake, S; Taoka, T; Maeda, M; Yuh, WTC
    • Journal Title

      NEURORADIOLOGY JOURNAL

      Volume: 31 Pages: 336-344

    • DOI

      10.1177/1971400918769911

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prediction of Intracranial Arterial Stenosis Progression in Patients with Moyamoya Vasculopathy: Contrast-Enhanced High-Resolution Magnetic Resonance Vessel Wall Imaging.2018

    • Author(s)
      Muraoka, S; Araki, Y; Taoka, T; Kawai, H; Okamoto, S; Uda, K; Ota, S; Naganawa, S; Wakabayashi, T
    • Journal Title

      World Neurosurg.

      Volume: 116

    • DOI

      10.1016/j.wneu.2018.05.181

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Imaging Differences between Neuromyelitis Optica Spectrum Disorders and Multiple Sclerosis: A Multi-Institutional Study in Japan2018

    • Author(s)
      Tatekawa, H; Sakamoto, S; Hori, M; Kaichi, Y; Kunimatsu, A; Akazawa, K; Miyasaka, T; Oba, H; Okubo, T; Hasuo, K; Yamada, K; Taoka, T; Doishita, S; Shimono, T; Miki, Y
    • Journal Title

      American Journal of Neuroradiology

      Volume: 39 Pages: 1239-1247

    • DOI

      10.3174/ajnr.a5663

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases2017

    • Author(s)
      Taoka T, Masutani Y, Kawai H, Nakane T, Matsuoka K, Yasuno F, Kishimoto T, Naganawa S.
    • Journal Title

      Japanese Journal of Radiology

      Volume: 35 Pages: 172-178

    • DOI

      10.1007/s11604-017-0617-z

    • NAID

      120006323685

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Revisiting Current Golden Rules in Managing Acute Ischemic Stroke: Evaluation of New Strategies to Further Improve Treatment Selection and Outcome2017

    • Author(s)
      William TC Yuh, Matthew David Alexander, Toshihiro Ueda, Masayuki Maeda, Toshiaki Taoka, Kei Yamada, Norman J Beauchamp
    • Journal Title

      AJR Am J Roentgenol

      Volume: 208 Pages: 32-41

    • DOI

      10.2214/ajr.16.16557

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Lack of Contrast Enhancement in a Giant Perivascular Space of the Basal Ganglion on Delayed FLAIR Images: Implications for the Glymphatic System2017

    • Author(s)
      Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka
    • Journal Title

      MRMS

      Volume: 印刷中 Issue: 2 Pages: 89-90

    • DOI

      10.2463/mrms.ci.2016-0114

    • NAID

      130005589284

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Visualization and Evaluation of Neurofluid Dynamics2019

    • Author(s)
      Toshiaki Taoka
    • Organizer
      13th Annual Meeting of the American Society of Functional Neuroradiology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Neurofluids and Glymphatic system2019

    • Author(s)
      Toshiaki Taoka
    • Organizer
      第4回国際磁気共鳴医学会 日本支部年次集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Imaging Brain Lymphatics2019

    • Author(s)
      Toshiaki Taoka
    • Organizer
      International Society of Magnetic Resonance in Medicine 27th Annual Meeting & Exhibition,
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Gadolinium Deposition in the Brain and Glymphatic System2019

    • Author(s)
      T Taoka, R Ito, R Nakamichi, T Nakane, H Kawai, S Naganawa
    • Organizer
      105th RSNA Scientific Assembly and Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gd presence in the brain: impact of daytime and anaesthesia2018

    • Author(s)
      Toshiaki Taoka, G. Jost, Shinji Naganawa, H. Pietsch
    • Organizer
      European Congress of Radiology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Diffusion Images to Explore Alzheimer's Disease2018

    • Author(s)
      Toshiaki Taoka
    • Organizer
      The 12th Asian-Oceanian Congress of Neuroradiolog
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Overview on Glymphatic System2018

    • Author(s)
      Toshiaki Taoka
    • Organizer
      The 12th Asian-Oceanian Congress of Neuroradiolog
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Controversies on Glymphatic Systems.2018

    • Author(s)
      Toshiaki Taoka
    • Organizer
      AOSNHNR session in ASNR 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Impact of the glymphatic system on the kinetric and distribution of gadodiamide in the rat brain: Observation by dynamic MRI and effect of circadian rhythm on tissue gadolinium concentrations.2018

    • Author(s)
      Toshiaki Taoka, Gregor Jost, Shinji Naganawa, Hubertus Pietsch
    • Organizer
      International Society for Magnetic Resonance in Medicine 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Diffusion Images for Assessing Glymphatic System2018

    • Author(s)
      Toshiaki Taoka
    • Organizer
      International Society for Magnetic Resonance in Medicine 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Glymphatic system: neuroimaging perspective.2018

    • Author(s)
      Toshiaki Taoka
    • Organizer
      The 74th Korean Congress of Radiology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] White matter microstructural changes in the cases of tuberous sclerosis Evaluation by NODDI compared with conventional diffusion tensor method.2018

    • Author(s)
      Toshiaki Taoka
    • Organizer
      104th Scientific Assembly and Annual Meeting of Radiological Society of North America
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] MRによる脳内の「動き」の可視化2018

    • Author(s)
      田岡俊昭
    • Organizer
      第41回日本脳神経CI学会総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 中枢神経組織でのガドリニウム造影剤2018

    • Author(s)
      田岡俊昭
    • Organizer
      第54回日本医学放射線学会秋季臨床大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Introduction for MR fingerprinting2018

    • Author(s)
      田岡俊昭
    • Organizer
      日本磁気共鳴医学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Diffusion Images to Explore Alzheimer's Disease2018

    • Author(s)
      Toshiaki Taoka
    • Organizer
      Symposium Neuroradiologicum 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Overview on Glymphatic System2018

    • Author(s)
      Toshiaki Taoka
    • Organizer
      Symposium Neuroradiologicum 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] State of the Art-Parkinson's Disease.2017

    • Author(s)
      Toshiaki Taoka
    • Organizer
      International Society for Magnetic Resonance in Medicine 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Venous Imaging2017

    • Author(s)
      Toshiaki Taoka
    • Organizer
      International Society for Magnetic Resonance in Medicine 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Book] Diffusion Tensor Imaging in Dementia. in Neuroimaging Diagnosis for Alzheimer's Disease and Other Dementias2017

    • Author(s)
      Toshiaki Taoka
    • Total Pages
      279
    • Publisher
      Springer
    • ISBN
      9784431551331
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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