MR strategies to solve problems after endovascular aortic repair.
Project/Area Number |
17K10398
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Nagoya University |
Principal Investigator |
Takehara Yasuo 名古屋大学, 医学系研究科, 寄附講座教授 (70188217)
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Co-Investigator(Kenkyū-buntansha) |
牛尾 貴輔 浜松医科大学, 医学部, 助教 (00402313)
海野 直樹 浜松医科大学, 医学部, 特任研究員 (20291958)
礒田 治夫 名古屋大学, 脳とこころの研究センター, 教授 (40223060)
長縄 慎二 名古屋大学, 医学系研究科, 教授 (50242863)
板谷 慶一 京都府立医科大学, 医学(系)研究科(研究院), 講師 (70458777)
駒田 智大 名古屋大学, 医学部附属病院, 助教 (80718354)
|
Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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Keywords | 腹部大動脈瘤 / 血流 / ステントグラフト / EVAR / 磁気共鳴画像 / MRI / MR angiography / 4D Flow / 4DFLOW / endoleak / 血流解析 / CT angiography / 大動脈瘤 / stent / MR Angiography |
Outline of Final Research Achievements |
Endovascular aneurysm repair (EVAR) has become a viable alternative to conventional surgical open repair owing to its perioperative survival benefit; however, EVAR is associated with a unique complication called endoleak (EL), which continues to perfuse and pressurize the aneurysm sac and cause aneurysm enlargement and rupture. Type I and type III endoleak were more detectable with MR angiography and streamline analysis with 4D Flow within the aneurysm. A comprehensive analysis of concurrent multiple T2EL vessels using 4D-flow MRI may enable prediction of the sac expansion after EVAR by larger amplitude of the flow velocity in the branch arteries.
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Academic Significance and Societal Importance of the Research Achievements |
高齢化が加速する本邦にあって、低侵襲治療であるEVARは今後も増加してゆく可能性が高いが、そのトレンドにあって、瘤破裂につながりかねないEVAR後のエンドリークの問題解決は焦眉の急と考えられる。本研究では、侵襲性の低い造影MR angiographyや4D Flow MRIといった新しい方法で従来法よりも高い感度でエンドリークを診断できる可能性が示された。流れという従来あまり利用されてこなかった学術的にも新規な方法論によって、腹部大動脈瘤の自然史解明につながる知見が得られた意義は大きい。
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Optimal Plane Selection for Measuring Post-prandial Blood Flow Increase within the Superior Mesenteric Artery: Analysis Using 4D Flow and Computational Fluid Dynamics2020
Author(s)
Masataka Sugiyama, Yasuo Takehara, Masanori Kawate, Naoki Ooishi, Masaki Terada, Haruo Isoda, Harumi Sakahara, Shinji Naganawa, Kevin M. Johnson, Oliver Wieben, Tetsuya Wakayama, Atsushi Nozaki, Hiroyuki Kabasawa
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Journal Title
Magnetic Resonance in Medical Sciences
Volume: 19
Issue: 4
Pages: 366-374
DOI
NAID
ISSN
1347-3182, 1880-2206
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Assessing the Risk of Intracranial Aneurysm Rupture Using Morphological and Hemodynamic Biomarkers Evaluated from Magnetic Resonance Fluid Dynamics and Computational Fluid Dynamics2020
Author(s)
Roshani Perera, Haruo Isoda, Kenta Ishiguro, Takashi Mizuno, Yasuo Takehara, Masaki Terada, Chiharu Tanoi, Takehiro Naito, Harumi Sakahara, Hisaya Hiramatsu, Hiroki Namba, Takashi Izumi, Toshihiko Wakabayashi, Takafumi Kosugi, Yuki Onishi, Marcus Alley, Yoshiaki Komori, Mitsuru Ikeda, Shinji Naganawa
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Journal Title
Magnetic Resonance in Medical Sciences
Volume: 19
Issue: 4
Pages: 333-344
DOI
NAID
ISSN
1347-3182, 1880-2206
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Accuracy of the Flow Velocity and Three-directional Velocity Profile Measured with Three-dimensional Cine Phase-contrast MR Imaging: Verification on Scanners from Different Manufacturers2019
Author(s)
Watanabe T, Isoda H, Fukuyama A, Takahashi M, Amano T, Takehara Y, Oishi N, Kawate M, Terada M, Kosugi T, Komori Y, Fukuma Y, Alley M
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Journal Title
Magnetic Resonance in Medical Sciences
Volume: 18
Issue: 4
Pages: 265-271
DOI
NAID
ISSN
1347-3182, 1880-2206
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Four-dimensional phase-contrast vastly undersampled isotropic projection reconstruction (4D PC-VIPR) MR evaluation of the renal arteries in transplant recipients: Preliminary results2017
Author(s)
Motoyama D, Ishii Y, Takehara Y, Sugiyama M, Yang W, Nasu H, Ushio T, Hirose Y, Ohishi N, Wakayama T, Kabasawa H, Johnson K, Wieben O, Sakahara H, Ozono S
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Journal Title
J Magn Reson Imaging
Volume: 46
Issue: 2
Pages: 595-603
DOI
Related Report
Peer Reviewed
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[Presentation] 4D-Flow: When and How?2018
Author(s)
Masataka Sugiyama, Yasuo Takehara, Tetsuya Wakayama, Atsushi Nozaki, Marcus Alley, Takasuke Ushio, Shinji Naganawa, Harumi Sakahara
Organizer
Radiological Society of North America 2018
Related Report
Int'l Joint Research
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