• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Comprehensive evaluation and treatment strategy for hematological disorder using whole-body MRI and next generation sequence

Research Project

Project/Area Number 17K10406
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionHiroshima University

Principal Investigator

Takasu Miyuki  広島大学, 病院(医), 病院助教 (70565647)

Co-Investigator(Kenkyū-buntansha) 粟井 和夫  広島大学, 医系科学研究科(医), 教授 (30294573)
川瀬 孝和  広島大学, 原爆放射線医科学研究所, 助教 (30463194)
高原 太郎  東海大学, 工学部, 教授 (50308467)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords多発性骨髄腫 / MRI / 骨髄腫 / 拡散強調像 / 内科
Outline of Final Research Achievements

Early change in FF of lumbar BM and serum M protein soon after induction of chemotherapy contributed significantly to prediction of CR/VGPR.CSI proved not to be useful for differentiating myeloma infiltration from hematopoietic BM.The CNN provided better differentiation of MDS from AA than conventional multiparametric MRI and visual inspection of human observers.

Academic Significance and Societal Importance of the Research Achievements

造血器腫瘍に対しMRIと最新の撮像・解析技術を用いる骨髄の包括的評価はこれまでに報告がなく、独創的な研究成果に立脚した発展的取り組みである。さらに、本研究は、骨髄病変の質的診断とその変化をもたらす背景因子の解明に繋がる重要な取り組みである。さらに、MRIによる全身骨の評価は、近年問題視されている医療被曝を軽減するためのプロトコル立案に大きく貢献するものである。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (21 results)

All 2020 2019 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (18 results) (of which Int'l Joint Research: 7 results,  Invited: 10 results) Book (1 results)

  • [Journal Article] Assessment of early treatment response on MRI in multiple myeloma: comparative study of whole-body and lumbar spinal MRI.2020

    • Author(s)
      Miyuki Takasu, Shota Kondo, Yuji Akiyama, Yuji Takahashi, Shogo Maeda, Yasutaka Baba, Takakazu Kawase, Tatsuo Ichinohe, Kazuo Awai
    • Journal Title

      PLoS One

      Volume: 15 Issue: 2 Pages: e0229607-e0229607

    • DOI

      10.1371/journal.pone.0229607

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] How to Improve the Conspicuity of Breast Tumors on Computed High <i>b</i>-value Diffusion-weighted Imaging2019

    • Author(s)
      Tamura T, Takasu M, Higaki T, Yokomachi K, Akiyama Y, Sumida H, Nagata Y, Awai K
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 18 Issue: 2 Pages: 119-125

    • DOI

      10.2463/mrms.mp.2018-0011

    • NAID

      130007630068

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Differentiation of myelodysplastic syndrome from aplastic anemia using conventional multiparametric MRI and Machine Learning2019

    • Author(s)
      Miyuki Takasu, Takashi Abe, Yasutaka Baba, Takakazu Kawase, Shogo Maeda, Kazuo Awai, Akira Nishikori, Tatsuo Ichinohe
    • Organizer
      Radiological Society of North America 105th Scientific Assembly and Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 発性骨髄腫患者における全身Diffusion-weighted MRIと18F-FDG-PET/CT2019

    • Author(s)
      高須深雪
    • Organizer
      第56回腫瘍・免疫核医学研究会/第38回呼吸器核医学研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 多発性骨髄腫の画像所見2019

    • Author(s)
      高須深雪
    • Organizer
      多発性骨髄腫web セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 骨病変の画像診断と骨強度解析2019

    • Author(s)
      高須深雪
    • Organizer
      第1回骨髄腫セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Quantitative comparison of conventional and synthetic MRI for cortical and trabecular bone architecture: ex vivo study of bovine coccyx2019

    • Author(s)
      Miyuki Takasu, Yuji Akiyama, Akira Nishikori, Yoko Kaichi, Shogo Maeda, Kazuo Awai
    • Organizer
      International Society for Magnetic Resonance in Medicine 27th Annual Meeting & Exhibition
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 血液疾患におけるwhole body diffusionの有用性2019

    • Author(s)
      高須深雪
    • Organizer
      DWIBS講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Utility of CT metal artifact reduction algorithms for intervertebral devices: experimental study in ex vivo bovine coccyx using micro-CT as the reference standard2018

    • Author(s)
      Miyuki Takasu, Kazuyoshi Nakanishi, Chikako Fujioka, Shota Kondo Tomoyo Fuji, Chihiro Tani, Masao Kiguchi, Kazuo Awai
    • Organizer
      RSNA 104th Scientific Meeting And Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Assessment of early treatment response by MRI in multiple myeloma: comparative study of whole-body MRI and lumbar spinal MRI2018

    • Author(s)
      Miyuki Takasu, Yuji Akiyama, Kazushi Yokomachi, Tomoyo Fuji, Shota Kondo, Hiroaki Sakane, Chihiro Tani, Kazuo Awai 1
    • Organizer
      RSNA 104th Scientific Meeting And Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 多発性骨髄腫の骨病変: 臨床用CTによる骨梁解析と 全身MRIによる評価2018

    • Author(s)
      高須深雪
    • Organizer
      中国四国骨髄腫カンファレンス
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 多発性骨髄腫の骨病変: 臨床用CTによる骨梁解析と 全身MRIによる評価2018

    • Author(s)
      高須深雪
    • Organizer
      Osaka Myeloma Conference
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 多発性骨髄腫と骨病変2018

    • Author(s)
      高須深雪
    • Organizer
      社外講師勉強会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 全身MRIを用いた多発性骨髄腫の治療効果判定と予後予測2018

    • Author(s)
      高須深雪
    • Organizer
      第8回 Hematological imaging and therapeutic seminar
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] BD Scoreを用いた骨髄腫の寛解予測: Fat Fractionとの比較2018

    • Author(s)
      高須深雪
    • Organizer
      第9回Body DWI研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Assessment of early treatment response by multiparametric whole-body MRI as a 1-step approach to prediction of overall response rate in patients with multiple myeloma2018

    • Author(s)
      Miyuki Takasu, Takayuki Tamura, Yuji Akiyama, Yoko Kaichi, Shota Kondo, Chihiro Tani, Kazuo Awai
    • Organizer
      ISMRM 26th Scientific Meeting And Exhibition
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Does chemical shift imaging offer a biomarker for the diagnosis and assessment of disease severity in multiple myeloma?2018

    • Author(s)
      Miyuki Takasu, Yuji Akiyama, Takayuki Tamura, Shota Kondo, Chihiro Tani, Akira Sakai, Tatsuo Ichinohe, Kazuo Awai
    • Organizer
      ISMRM 26th Scientific Meeting And Exhibition
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of chemical shift imaging for diagnosis and disease severity of multiple myeloma2017

    • Author(s)
      高須深雪
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Preliminary Investigation: Gaussian and Non-Gaussian Measurements of Water Diffusion in Diagnostic Differentiation of Focal Lesions of Malignant Spinal Bone Tumors2017

    • Author(s)
      MIYUKI TAKASU
    • Organizer
      ISMRM 25th Annual Meeting & Exhibition
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 多発性骨髄腫に対するevidence2017

    • Author(s)
      高須深雪
    • Organizer
      第7回 Body DWI 研究会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] 画像所見から絞り込む!頭部画像診断2018

    • Author(s)
      高須深雪
    • Total Pages
      295
    • Publisher
      羊土社
    • ISBN
      9784758111881
    • Related Report
      2018 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi