Monitoring high grade glioma and evaluation of prognostic value by APT imaging

• Project/Area Number: 17K10410
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: TOGAO OSAMU 九州大学, 大学病院, 助教講師 (10452749)
• Co-Investigator(Kenkyū-buntansha): 樋渡 昭雄 九州大学, 医学研究院, 准教授 (30444855) ; 空閑 太亮 九州大学, 大学病院, 助教 (40759932) ; 吉本 幸司 鹿児島大学, 医歯学域医学系, 教授 (70444784) ; 山下 孝二 九州大学, 大学病院, 助教 (80546565) ; 本田 浩 九州大学, 大学病院, 教授 (90145433)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: MRI / glioma / CEST / APTイメージング / 神経放射線 / グリオーマ / 分子イメージング / 医歯薬学 / 内科系臨床医学 / 放射線科学 / 脳腫瘍

Outline of Final Research Achievements

In the present study, we first developed the clinical amide proton transfer (APT) imaging sequence and optimized its parameters. We then evaluated its clinical usefulness in glioma patients. We employed Dixon method for B0 inhomogeneity correction in the 3D fast spin-echo sequence. The APT-weighted signals of tumor measured with the 3D-Dixon sequence was almost identical to those with single slice 2D sequence. With this condition, it was able to monitor the temporal progression of glioma, evaluate therapeutic response to anti-cancer drugs such as temozolomide and bevasizumab, and differentiate radiation induced necrosis from tumor progression. APT imaging can be a non-ivasive clinical tool to assess and monitor temporal changes in gliomas.

Academic Significance and Societal Importance of the Research Achievements

本研究では新しいMRIのコントラストを用いたAmide proton transfer （APT）イメージングの臨床使用に最適なシークエンスの開発を行い、その最適化をおこった。それを用いた臨床評価ではAPTイメージングはグリオーマの悪性度の進行の評価、化学療法後の治療効果判定および治療中のモニタリング、放射線治療による壊死と腫瘍進行との鑑別が可能であり、その臨床的有用性は高いと考えられた。

Research Products

• [Journal Article] Acceleration-selective arterial spin labeling MR angiography for visualization of brain arteriovenous malformations. (2019)
  • Author(s): Togao O, Hiwatashi A, Yamashita K, Momosaka D, Obara M, Nishimura A, Arimura K, Hata N, Iihara K, Van Cauteren M, Honda H.
  • Journal Title: Neuroradiology. Volume: 61 Pages: 979-989
  • Peer Reviewed
• [Journal Article] Amide proton transfer (APT) magnetic resonance imaging of endometrioid endometrial adenocarcinoma: association with histologic grade. (2018)
  • Author(s): Yukihisa Takayama, Akihiro Nishie, Osamu Togao, Yoshiki Asayama, Kousei Ishigami, Yasuhiro Ushijima, Daisuke Okamoto, Nobuhiro Fujita, Kenzo Sonoda, Tomoyuki Hida, Yoshihiro Ohishi, Jochen Keupp, Hiroshi Honda.
  • Journal Title: Radiology Volume: 286 Issue: 3 Pages: 909-917
  • DOI: 10.1148/radiol.2017170349
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Amide proton transfer imaging to predict tumor response to neoadjuvant chemotherapy in locally advanced rectal cancer (2018)
  • Author(s): Nishie Akihiro、Asayama Yoshiki、Ishigami Kousei、Ushijima Yasuhiro、Takayama Yukihisa、Okamoto Daisuke、Fujita Nobuhiro、Tsurumaru Daisuke、Togao Osamu、Sagiyama Koji、Manabe Tatsuya、Oki Eiji、Kubo Yuichiro、Hida Tomoyuki、Hirahashi-Fujiwara Minako、Keupp Jochen、Honda Hiroshi
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: 34 Issue: 1 Pages: 140-146
  • DOI: 10.1111/jgh.14315
• [Journal Article] Amide proton transfer imaging of brain tumors using a self-corrected 3D fast spin-echo Dixon method: comparison with separate B0 correction. (2017)
  • Author(s): Togao O, Keupp J, Hiwatashi A, Yamashita K, Kikuchi K, Yoneyama M, Honda H.
  • Journal Title: Magn Reson Med. Volume: 77 Issue: 2 Pages: 2272-2279
  • DOI: 10.1002/mrm.27074
  • Peer Reviewed
• [Presentation] Toward Clinical Application of Chemical Exchange Saturation Transfer (CEST) Imaging in Neuroradiology (2019)
  • Author(s): Osamu Togao
  • Organizer: 第47回日本磁気共鳴医学会大会
  • Invited
• [Presentation] APT-w Imaging in Cancer Clinical Practice (2018)
  • Author(s): Togao O
  • Organizer: The 7th International Workshop on Chemical Exchange Saturation Transfer (CEST) imaging
  • Invited
• [Presentation] Magnetization Transfer Ratio based Metric for APTw or CESTw MRI Suppressing Signal from Fluid Compartments - Initial Application to Glioblastoma Assessment (2018)
  • Author(s): Keupp O, Togao O
  • Organizer: International Society for Magnetic Resonance in Medicine 2019
  • Int'l Joint Research