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Fundamental Study on MRI Measurement of Global Brain Activity - Cerebral Blood Flow - Cerebral Temperature

Research Project

Project/Area Number 17K10413
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Sakai Koji  京都府立医科大学, 医学(系)研究科(研究院), 准教授 (20379027)

Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords脳活動 / 脳血流量 / 脳温度 / MRI / 脳脊髄液 / 拡散強調画像 / 拡散MRI
Outline of Final Research Achievements

The purpose of this study was to develop a method to measure the relationships among global brain activity-cerebral blood flow-brain temperature using only MRI. By providing a new index for observing brain status, the goal was to easily capture changes in brain function and activity associated with aging and other factors. In order to investigate the measurement methods that affect deep brain temperature measurement, we summarized the results of measuring the effect of CSF flow velocity on the relationship between brain temperature obtained by diffusion-weighted imaging and MR spectroscopy in 100 healthy subjects. The influence of CSF flow was found to be limited, and the brain temperature calculated from DWI could be used regardless of the randomness or size of the flow.

Academic Significance and Societal Importance of the Research Achievements

グローバルCMRO2-CBF-TBは、互いに密接に結びついて脳の状態を維持している。これらの情報が、MRIのみで非侵襲かつ容易に収集可能になるならば、人間科学的および病態把握のための有益な知見が、追加のコストなしに日々の臨床検査等から得られ、脳状態把握の有益なツールになると考えられる。脳温度が拡散強調画像の一般的な撮像手法から類推され、病態等との差異があることを見出したことに学術的な意義がある。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (45 results)

All 2022 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (15 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 13 results,  Open Access: 1 results) Presentation (27 results) (of which Int'l Joint Research: 11 results,  Invited: 7 results) Book (1 results)

  • [Int'l Joint Research] IRCCS-ISMETT(イタリア)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] IRCCS-ISMETT/University of Palermo(イタリア)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Does cerebrospinal fluid pulsation affect diffusion‐weighted imaging thermometry? A study in healthy volunteers2022

    • Author(s)
      Sakai Koji、Kentaro Akazawa、Tazoe Jun、Ikeno Hiroyasu、Nakagawa Toshiaki、Yamada Kei
    • Journal Title

      NMR in Biomedicine

      Volume: - Issue: 8

    • DOI

      10.1002/nbm.4738

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low‐grade IVH in preterm infants causes cerebellar damage, motor, and cognitive impairment2021

    • Author(s)
      Sakaue Satoshi、Hasegawa Tatsuji、Sakai Koji、Zen Yui、Tozawa Takenori、Chiyonobu Tomohiro、Yamada Kei、Morimoto Masafumi、Hosoi Hajime
    • Journal Title

      Pediatrics International

      Volume: 63 Issue: 11 Pages: 1327-1333

    • DOI

      10.1111/ped.14691

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Temperature Measurement by Diffusion-Weighted Imaging2021

    • Author(s)
      Sparacia Gianvincenzo、Sakai Koji
    • Journal Title

      Magnetic Resonance Imaging Clinics of North America

      Volume: 29 Issue: 2 Pages: 253-261

    • DOI

      10.1016/j.mric.2021.02.005

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 拡散MRI:基礎と計測手法2021

    • Author(s)
      酒井 晃二
    • Journal Title

      Journal of the Society of Biomechanisms

      Volume: 45 Issue: 1 Pages: 14-20

    • DOI

      10.3951/sobim.45.1_14

    • NAID

      130008150357

    • ISSN
      0285-0885
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2. Radiomics of MRI2021

    • Author(s)
      Sakai Koji
    • Journal Title

      Japanese Journal of Radiological Technology

      Volume: 77 Issue: 8 Pages: 866-875

    • DOI

      10.6009/jjrt.2021_JSRT_77.8.866

    • NAID

      130008076312

    • ISSN
      0369-4305, 1881-4883
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 拡散MRI:基礎と計測手法2021

    • Author(s)
      酒井晃二
    • Journal Title

      バイオメカニズム学会誌

      Volume: 45 Pages: 14-14

    • NAID

      130008150357

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Machine learning studies on pediatric diseases2020

    • Author(s)
      酒井 晃二
    • Journal Title

      Journal of Japanese Society of Pediatric Radiology

      Volume: 36 Issue: 1 Pages: 35-45

    • DOI

      10.20844/jspr.36.1_35

    • NAID

      130007815390

    • ISSN
      0918-8487, 2432-4388
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 人工知能時代の放射線医学2019

    • Author(s)
      酒井晃二, 山田 惠
    • Journal Title

      Journal of Kyoto Prefectural University of Medicine

      Volume: 128 Issue: 6 Pages: 407-419

    • DOI

      10.32206/jkpum.128.06.407

    • ISSN
      0023-6012
    • Year and Date
      2019-06-25
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] ADCとradiomics2019

    • Author(s)
      酒井晃二, 山田 惠
    • Journal Title

      日獨医報

      Volume: 64 Pages: 64-88

    • Related Report
      2019 Research-status Report
  • [Journal Article] 拡散MRIを用いた定量2019

    • Author(s)
      酒井晃二
    • Journal Title

      RadFan

      Volume: 17 Pages: 32-36

    • Related Report
      2019 Research-status Report
  • [Journal Article] Whole-tumor histogram analysis of DWI and QSI for differentiating between meningioma and schwannoma: a pilot study2019

    • Author(s)
      Hitomi Nagano, Koji Saka, Jun Tazoe, Masashi Yasuike, Kentaro Akazawa, Kei Yamada
    • Journal Title

      Japanese Journal of Radiology

      Volume: 37 Issue: 10 Pages: 694-700

    • DOI

      10.1007/s11604-019-00862-y

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Machine learning studies on major brain diseases: 5-year trends of 2014?20182018

    • Author(s)
      Sakai Koji、Yamada Kei
    • Journal Title

      Japanese Journal of Radiology

      Volume: 37 Issue: 1 Pages: 34-72

    • DOI

      10.1007/s11604-018-0794-4

    • NAID

      210000172888

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Brain-core temperature of patients before and after orthotopic liver transplantation assessed by DWI thermometry2018

    • Author(s)
      Sparacia Gianvincenzo、Cannella Roberto、Lo Re Vincenzina、Mamone Giuseppe、Sakai Koji、Yamada Kei、Miraglia Roberto
    • Journal Title

      Japanese Journal of Radiology

      Volume: 36 Issue: 5 Pages: 324-330

    • DOI

      10.1007/s11604-018-0729-0

    • NAID

      50012894413

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical feasibility of simultaneous multi-slice imaging with blipped-CAIPI for diffusion-weighted imaging and diffusion-tensor imaging of the brain2017

    • Author(s)
      Yokota Hajime、Sakai Koji、Tazoe Jun、Goto Mariko、Imai Hiroshi、Teramukai Satoshi、Yamada Kei
    • Journal Title

      Acta Radiologica

      Volume: 58 Issue: 12 Pages: 1500-1510

    • DOI

      10.1177/0284185117692171

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Radiomics in MRI field2017

    • Author(s)
      酒井晃二
    • Journal Title

      JMI Report

      Volume: 11 Pages: 3-10

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Commercially available astriction cotton as a anisotropic DTI phantom: Comparisons with a hand-bundled fibers and a glass capillary plate2021

    • Author(s)
      Koji Sakai, Yasuhiko Tachibana,Toshiaki Nakagawa,Hiroyasu Ikeno, Takayuki Obata, Kei Yamada
    • Organizer
      The 29th International Society for Magnetic Resonance in Medicine (ISMRM2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Adequate mixing time for double diffusion encoding in normal brain structures and brain tumors2021

    • Author(s)
      Kentaro Akazawa, Koji Sakai, Tomoaki Kitaguchi, Tomonori Toyotsuji, Thorsten Feiweier, Hiroshi Imai, and Kei Yamada
    • Organizer
      The 29th International Society for Magnetic Resonance in Medicine (ISMRM2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 地域社会の健常成人における年齢・性別による局所脳体積変化の縦断的検討2021

    • Author(s)
      赤澤 健太郎,栗山 長門,尾﨑 悦子,松井 大輔,小山 晃英,酒井 晃二,高田 明浩,丸中 良典, 水野 敏樹,上原 里程,山田 惠
    • Organizer
      第50回 日本神経放射線学会
    • Related Report
      2021 Annual Research Report 2020 Research-status Report
  • [Presentation] 地域在住成人における局所脳体積比とMini-Mental State Examinationの相関2021

    • Author(s)
      赤澤 健太郎,栗山 長門,尾﨑 悦子,松井 大輔,小山 晃英,酒井 晃二,高田 明浩,丸中 良典, 水野 敏樹,上原 里程,山田 惠
    • Organizer
      第49回日本磁気共鳴医学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 圧縮センシングは脳の定量的MRI測定に有用か?:健常者による検討2021

    • Author(s)
      北口知明、赤澤健太郎、酒井晃二、山田惠, 和田裕也、山村健太郎、竹島雄太、田中健太郎、タイン・ゴック・チャム、藤原春樹、池野寛康、中川稔章
    • Organizer
      第49回日本磁気共鳴医学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 乳癌のRadiomics2021

    • Author(s)
      酒井晃二
    • Organizer
      第18回 日本乳癌学会九州地方会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Cerebrospinal fluid pulsation does not affect on DWI-based thermometry: healthy volunteer study2020

    • Author(s)
      Koji Sakai, Jun Tazoe, Kentaro Akazawa, Hiroyasu Ikeno, Toshiaki Nakagawa, Kei Yamada
    • Organizer
      The 28th International Society for Magnetic Resonance in Medicine (ISMRM2020)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Experience counts! Comparison of ROI placement strategies for radiomics analysis of gliomas2020

    • Author(s)
      Barbara Schmitz Abecassis, Koji Sakai, Tomonori Toyotsuji, Yoshiaki Ota, Kei Yamada
    • Organizer
      he 28th International Society for Magnetic Resonance in Medicine (ISMRM2020)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Higher DWI S-index values in Breast Invasive Carcinoma are correlated with better prognostic factors2020

    • Author(s)
      Mariko Goto, Denis Le Bihan, Koji Sakai, Kei Yamada
    • Organizer
      106th Scientific Assembly and Annual Meeting of Radiological Society of North America (RSNA2020)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] がん診療における画像のRadiomics2020

    • Author(s)
      酒井晃二
    • Organizer
      第47回日本集中治療医学会学術集会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Does cerebrospinal fluid pulsation affect DWI thermometry?: healthy volunteer study2019

    • Author(s)
      1)Koji Sakai, Jun Tazoe, Kentaro Akazawa, Masashi Yasuike, Hiroyasu Ikeno, Toshiaki Nakagawa, Barbara Schmitz Abecassis, Kei Yamada
    • Organizer
      International Society for Magnetic Resonance in Medicine (ISMRM 2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Radiogenomicsへの期待2019

    • Author(s)
      酒井晃二
    • Organizer
      日本医学放射線総会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Double Diffusion EncodingとSingle Diffusion Encodingによる拡散強調画像におけるFAとADCの比較検討2019

    • Author(s)
      3)Ikeno H, Akazawa K, Imai H, Nakagawa T, Bamba C, Tazoe J, Sakai K, Tamaki N, Yamada K
    • Organizer
      日本磁気共鳴医学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Brain core temperature of patients before and after orthotopic liver transplantation assessed by diffusion weighted imaging thermometry2018

    • Author(s)
      1.Sparacia G, Lo Re V, Yamada K, Sakai K, Cannella R, Gentile G, Mamone G, Miraglia R
    • Organizer
      European Congress of Radiology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Brain q-space imaging: Mean displacement measurement by SMS, grid sampling, and multi-shell QSI2018

    • Author(s)
      2.Koji Sakai, Hiroyasu Ikeno, Hiroshi Imai, Kentaro Akazawa, Masashi Yasuike, Hitomi Nagano, Kei Yamada
    • Organizer
      International Society for Magnetic Resonance in Medicine
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] DWI thermometry: its potential and challenges2018

    • Author(s)
      Koji Sakai
    • Organizer
      Korean Society for Boitechnology and Bioengineering
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Tissue correlation time mapping by MR fingerprinting: Evaluation in normal brain2018

    • Author(s)
      4.Taoka T, Kawai H, Nakane T, Kawaguchi H, Maruyama K, Murata K, Nittka M, Sakai K, Yamada K, Naganawa S
    • Organizer
      日本磁気共鳴医学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] An affordable phantom for ADC/FA; a device for multi-site studies2017

    • Author(s)
      1)Sakai K, Nakagawa T, Nakai R, Ikeno H, Yamaguchi S, Takadama H, Yamada K
    • Organizer
      International Society for Magnetic Resonance in Medicine
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Simultaneous muilti-slice (SMS) echo planar imaging (EPI); which combination of parameters is clinically most efficient?2017

    • Author(s)
      akai K, Imai H, Ikeno H, Tazoe J, Yasuike M, Nagano H, Bhat H
    • Organizer
      International Society for Magnetic Resonance in Medicine
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Can q-space imaging differentiate meningioma from cranial nerve schwannoma?2017

    • Author(s)
      3)Nagano H, Sakai K, Tazoe J, Yasuike M, Yokota H, Akazawa K, Hashimoto N, Yamada K
    • Organizer
      International Society for Magnetic Resonance in Medicine
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Systemic inflammation and brain temperature in Parkinson’s disease2017

    • Author(s)
      Chen HL, Sakai K, Lin WC, Yamada K
    • Organizer
      日本磁気共鳴医学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Comparison of DTI measures among five different MRI scanners using anisotropic diffusion phantom: 1 year results of round robin test2017

    • Author(s)
      Yasuike M, Sakai K, Nakai R, Nakagawa T, Ikeno H, Yamada K
    • Organizer
      日本磁気共鳴医学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Brain q-space imaging: Mean displacement measurement by SMS, grid sampling, and multi-shell QSI2017

    • Author(s)
      Ikeno H, Sakai K, Nakagawa T, Imai H, Yasuike M, Nagano H, Akazawa K, Yamada K
    • Organizer
      日本磁気共鳴医学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Comparisons of DTI measures among twelve different MRI scanners using anisotropic diffusion phantom2017

    • Author(s)
      Sakai K, Murata S, Nakai R, Nakagawa T, Ikeno H, Hori M, Yamada K, Aoki S
    • Organizer
      日本磁気共鳴医学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Diffusion as a Biomarker2017

    • Author(s)
      Koji Sakai
    • Organizer
      International Society for Magnetic Resonance in Medicine
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Radiomics on MRI field2017

    • Author(s)
      Koji Sakai
    • Organizer
      Molecular Imaging World Congress
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Diffusion and Brain Temperature2017

    • Author(s)
      Koji Sakai
    • Organizer
      Korean Congress of Radiology
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] 頭部画像診断の勘ドコロNEO 第2章 4.拡散MR画像2021

    • Author(s)
      田岡 俊昭
    • Total Pages
      552
    • Publisher
      メジカルビュー社
    • ISBN
      9784758316132
    • Related Report
      2020 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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