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Machine learning for diagnosis of early Alzheimer's disease

Research Project

Project/Area Number 17K10414
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Yamada Kei  京都府立医科大学, 医学(系)研究科(研究院), 教授 (80315960)

Project Period (FY) 2017-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsMRI / 拡散強調画像 / アルツハイマー病 / 教師付き機械学習 / deep learning / 拡散テンソル画像 / 機械学習 / 拡散MRI / 画像バイオマーカー / 医工連携
Outline of Final Research Achievements

Our research focused on DWI and q-space imaging (QSI). We shortened the scan time of QSI[1] and also the regular DWI using Simultaneous Multi-Slice technique[2]. We have also worked on post-processing techniques, namely TRACULA for Alzheimer’s disease (AD) patients[3] and automated segmentation tool [4]. We also did temperature measurements[5-7]. We also used high-resolution T1-weighted images and showed that AD patients tend to have smaller pineal gland [8] and volume loss in precuneous regions[9]. In another research, we have shown that specific regions of the brain are correlated to specific test results [10]. We also conducted a study on serum biomarker [11]. We also participated in a trial of amyloid PET studies [12].
Our research also focuses on machine learning (ML). We worked on developing ML that aids in diagnosis of AD. We first investigated the publications in the past 5 years[13]. We have also made predictions as to how this technique is going to affect us[14].

Academic Significance and Societal Importance of the Research Achievements

日本国民の急速な高齢化に伴い、認知症は万人の関心事項となった。中でもアルツハイマー病は最も頻度の高い認知症の一つである。その原因として有力視されているアミロイド沈着に対する薬剤の開発が進んでおり、早期発見の意義が高まっている。すなわち、アルツハイマーの可能性を早く確実に見つける事ができると先制治療が可能かもしれない。本研究は画像を用いた早期発見への礎であり、社会的に重要な意義が存在する。

Report

(7 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (28 results)

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article (21 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 21 results,  Open Access: 12 results) Presentation (7 results) (of which Int'l Joint Research: 4 results,  Invited: 3 results)

  • [Journal Article] Association between cerebrovasoreactivity and stroke in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy2023

    • Author(s)
      Mukai Mao、Hamano Ai、Mizuta Ikuko、Yokota Isao、Watanabe-Hosomi Akiko、Matsuura Hiraku、Koizumi Takashi、Matsuura Jun、Ohara Tomoyuki、Matsushima Shigenori、Teramukai Satoshi、Yamada Kei、Mizuno Toshiki
    • Journal Title

      Frontiers in Neurology

      Volume: 13 Pages: 1087220-1087220

    • DOI

      10.3389/fneur.2022.1087220

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Does cerebrospinal fluid pulsation affect diffusion‐weighted imaging thermometry? A study in healthy volunteers2022

    • Author(s)
      Sakai Koji、Kentaro Akazawa、Tazoe Jun、Ikeno Hiroyasu、Nakagawa Toshiaki、Yamada Kei
    • Journal Title

      NMR in Biomedicine

      Volume: - Issue: 8

    • DOI

      10.1002/nbm.4738

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DWI-based MR thermometry: could it discriminate Alzheimer’s disease from mild cognitive impairment and healthy subjects?2022

    • Author(s)
      Asfuro?lu Berrak Barutcu、Topkan Tu?berk Anda?、Kaydu Nesrin Erdo?an、Sakai Koji、?ner Ali Yusuf、Karaman Yahya、Yamada Kei、Tali E. Turgut
    • Journal Title

      Neuroradiology

      Volume: 64 Issue: 10 Pages: 1979-1987

    • DOI

      10.1007/s00234-022-02969-y

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association Between Cerebral Microbleeds and Circulating Levels of Mid-Regional Pro-Adrenomedullin2022

    • Author(s)
      Kuriyama Nagato、Koyama Teruhide、Ozaki Etsuko、Saito Satoshi...
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: 88 Issue: 2 Pages: 731-741

    • DOI

      10.3233/jad-220195

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical impact of amyloid PET using 18F-florbetapir in patients with cognitive impairment and suspected Alzheimer's disease: a multicenter study.2022

    • Author(s)
      Matsuda H, Okita K, Motoi Y, Mizuno T, Ikeda M, Sanjo N, Murakami K, Kambe T, Takayama T, Yamada K, Suehiro T, Matsunaga K, Yokota T, Tateishi U, Shigemoto Y, Kimura Y, Chiba E, Kawashima T, Tomo Y, Tachimori H, Kimura Y, Sato N
    • Journal Title

      Ann Nucl Med

      Volume: 36 Issue: 12 Pages: 1039-1049

    • DOI

      10.1007/s12149-022-01792-y

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Artificial intelligence trained with integration of multiparametric MR‐US imaging data and fusion biopsy trajectory‐proven pathology data for 3D prediction of prostate cancer: A proof‐of‐concept study2022

    • Author(s)
      Kaneko Masatomo、Fukuda Norio、Nagano Hitomi、Yamada Kaori、Yamada Kei、Konishi Eiichi、Sato Yoshinobu、Ukimura Osamu
    • Journal Title

      The Prostate

      Volume: 82 Issue: 7 Pages: 793-803

    • DOI

      10.1002/pros.24321

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assessment of biventricular hemodynamics and energy dynamics using lumen-tracking 4D flow MRI without contrast medium2021

    • Author(s)
      Nakaji Kosuke、Itatani Keiichi、Tamaki Nagara、Morichi Hiroko、Nakanishi Naohiko、Takigami Masao、Yamagishi Masaaki、Yaku Hitoshi、Yamada Kei
    • Journal Title

      Journal of Cardiology

      Volume: 78 Issue: 1 Pages: 79-87

    • DOI

      10.1016/j.jjcc.2021.01.004

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Low‐grade IVH in preterm infants causes cerebellar damage, motor, and cognitive impairment2021

    • Author(s)
      Sakaue Satoshi、Hasegawa Tatsuji、Sakai Koji、Zen Yui、Tozawa Takenori、Chiyonobu Tomohiro、Yamada Kei、Morimoto Masafumi、Hosoi Hajime
    • Journal Title

      Pediatrics International

      Volume: 63 Issue: 11 Pages: 1327-1333

    • DOI

      10.1111/ped.14691

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison between dynamic whole-body FDG-PET and early-delayed imaging for the assessment of motion in focal uptake in colorectal area2021

    • Author(s)
      Kotani Tomoya、Nishimura Motoki、Tamaki Nagara、Matsushima Shigenori、Akiyama Shimpei、Kanayama Taisei、Bamba Chisa、Tanada Yasutomo、Nii Takeshi、Yamada Kei
    • Journal Title

      Annals of Nuclear Medicine

      Volume: 35 Issue: 12 Pages: 1305-1311

    • DOI

      10.1007/s12149-021-01671-y

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Radiologic-pathologic association of tumor‐like lesions with inflammation in cerebral white matter: Comparison of two cases with distinct clinical outcomes2021

    • Author(s)
      Shishido‐Hara Yukiko、Akazawa Kentaro、Takeuchi Hayato、Hirato Junko、Konishi Eiichi、Yamada Kei、Itoh Kyoko、Hashimoto Naoya
    • Journal Title

      Neuropathology

      Volume: 41 Issue: 6 Pages: 468-475

    • DOI

      10.1111/neup.12766

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pineal volume reduction in patients with mild cognitive impairment who converted to Alzheimer's disease2020

    • Author(s)
      Matsuoka Teruyuki、Oya Nozomu、Yokota Hajime、Akazawa Kentaro、Yamada Kei、Narumoto Jin、for the Alzheimer's Disease Neuroimaging Initiative
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 74 Issue: 11 Pages: 587-593

    • DOI

      10.1111/pcn.13103

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alteration of brain temperature and systemic inflammation in Parkinson's disease.2020

    • Author(s)
      Chen HL, Yamada K, Sakai K, Lu CH, Chen MH, Lin WC.
    • Journal Title

      Neurol Sci.

      Volume: Jan 10 Issue: 5 Pages: 1267-1276

    • DOI

      10.1007/s10072-019-04217-3

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Whole-tumor histogram analysis of DWI and QSI for differentiating between meningioma and schwannoma: a pilot study2019

    • Author(s)
      Hitomi Nagano, Koji Saka, Jun Tazoe, Masashi Yasuike, Kentaro Akazawa, Kei Yamada
    • Journal Title

      Japanese Journal of Radiology

      Volume: 37 Issue: 10 Pages: 694-700

    • DOI

      10.1007/s11604-019-00862-y

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Automated Generation of Radiologic Descriptions on Brain Volume Changes From T1-Weighted MR Images: Initial Assessment of Feasibility2019

    • Author(s)
      Akazawa Kentaro、Sakamoto Ryo、Nakajima Satoshi、Wu Dan、Li Yue、Oishi Kenichi、Faria Andreia V.、Yamada Kei、Togashi Kaori、Lyketsos Constantine G.、Miller Michael I.、Mori Susumu
    • Journal Title

      Frontiers in Neurology

      Volume: 10

    • DOI

      10.3389/fneur.2019.00007

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] The day when computers read between lines2019

    • Author(s)
      Yamada Kei、Mori Susumu
    • Journal Title

      Japanese Journal of Radiology

      Volume: 37 Issue: 5 Pages: 351-353

    • DOI

      10.1007/s11604-019-00833-3

    • NAID

      50014127801

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] The detection of white matter alterations in obsessive–compulsive disorder revealed by TRActs Constrained by UnderLying Anatomy (TRACULA)2018

    • Author(s)
      Watanabe Anri、Nakamae Takashi、Sakai Yuki、Nishida Seiji、Abe Yoshinari、Yamada Kei、Yokota Isao、Narumoto Jin
    • Journal Title

      Neuropsychiatric Disease and Treatment

      Volume: 14 Pages: 1635-1643

    • DOI

      10.2147/ndt.s164058

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduced Pineal Volume in Alzheimer Disease: A Retrospective Cross-sectional MR Imaging Study2018

    • Author(s)
      Matsuoka Teruyuki、Imai Ayu、Fujimoto Hiroshi、Kato Yuka、Shibata Keisuke、Nakamura Kaeko、Yokota Hajime、Yamada Kei、Narumoto Jin
    • Journal Title

      Radiology

      Volume: 286 Issue: 1 Pages: 239-248

    • DOI

      10.1148/radiol.2017170188

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differences in the neural correlates of frontal lobe tests2018

    • Author(s)
      Matsuoka Teruyuki、Kato Yuka、Imai Ayu、Fujimoto Hiroshi、Shibata Keisuke、Nakamura Kaeko、Yamada Kei、Narumoto Jin
    • Journal Title

      Psychogeriatrics

      Volume: 18 Issue: 1 Pages: 42-48

    • DOI

      10.1111/psyg.12285

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neural Correlates of Sleep Disturbance in Alzheimer’s Disease: Role of the Precuneus in Sleep Disturbance2018

    • Author(s)
      Matsuoka Teruyuki、Imai Ayu、Fujimoto Hiroshi、Kato Yuka、Shibata Keisuke、Nakamura Kaeko、Yokota Hajime、Yamada Kei、Narumoto Jin
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: Epub ahead of print Issue: 3 Pages: 1-8

    • DOI

      10.3233/jad-171169

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Machine learning studies on major brain diseases: 5-year trends of 2014?20182018

    • Author(s)
      Sakai Koji、Yamada Kei
    • Journal Title

      Japanese Journal of Radiology

      Volume: 37 Issue: 1 Pages: 34-72

    • DOI

      10.1007/s11604-018-0794-4

    • NAID

      210000172888

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical feasibility of simultaneous multi-slice imaging with blipped-CAIPI for diffusion-weighted imaging and diffusion-tensor imaging of the brain2017

    • Author(s)
      Yokota Hajime、Sakai Koji、Tazoe Jun、Goto Mariko、Imai Hiroshi、Teramukai Satoshi、Yamada Kei
    • Journal Title

      Acta Radiologica

      Volume: 58 Issue: 12 Pages: 1500-1510

    • DOI

      10.1177/0284185117692171

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Shape of radiology in the era of AI2019

    • Author(s)
      Kei Yamada
    • Organizer
      RCRT-RST 2019
    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Value based imaging: Future of radiology in the era of AI2019

    • Author(s)
      山田 惠
    • Organizer
      第78回日本医学放射線学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] The future of Radiology; Asian perspectives2018

    • Author(s)
      Yamada K
    • Organizer
      XXI Symposium Neuroradiologicum
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] "米国放射線科の現状2017

    • Author(s)
      山田 惠
    • Organizer
      第76回日本医学放射線学会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] n affordable phantom for ADC/FA; a device for multi-site studies2017

    • Author(s)
      Sakai K, Nakagawa T, Nakai R, Ikeno H, Yamaguchi S, Takadama H, Yamada K
    • Organizer
      The 25th International Society for Magnetic Resonance in Medicine
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Simultaneous muilti-slice (SMS) echo planar imaging (EPI); which combination of parameters is clinically most efficient?2017

    • Author(s)
      Sakai K, Imai H, Ikeno H, Tazoe J, Yasuike M, Nagano H, Bhat H, Yamada K
    • Organizer
      The 25th International Society for Magnetic Resonance in Medicine
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Can q-space imaging differentiate meningioma from cranial nerve schwannoma?2017

    • Author(s)
      Nagano H, Sakai K, Tazoe J, Yasuike M, Yokota H, Akazawa K, Hashimoto N, Yamada K
    • Organizer
      The 25th International Society for Magnetic Resonance in Medicine
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2024-01-30  

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