Research Project
Grant-in-Aid for Scientific Research (C)
脳に沈着したアミロイドを、位相差情報を反映した磁気共鳴画像(Phase Difference Enhanced Magnetic Resonance Imaging; PADRE)で可能であること、および、MRI拡散強調画像データを用いて脳温度を計測することが可能であることは、我々の先行研究により明らかとなっていました。本研究では、これらのMRI技術を日本で最も高頻度の認知症であるアルツハイマー病(AD)に適用し、ADの病態解明および早期診断法の開発を目指しました。本研究では、AD患者8名と年齢・性別をマッチさせた健常者10名を対象に、PADREとアミロイドPETを撮像しました。関心領域は、楔部・楔前部・上前頭回・上側頭回に設定しました。PADREの関心領域における低信号域を定性的・半定量的に解析し、アミロイドPETの関心領域におけるstandardized uptake value (SUV)比の平均値を計算しました。さらに、各関心領域におけるPADREの定性的評価、PADREの判定量的評価、アミロイドPETのSUV比の相関をSpearmanの相関係数で評価しました。その結果、楔前部ではPADREの定性的評価とアミロイドPETのSUV比の間に有意な相関が認められました(相関係数 = 0.5; P値 = 0.034)。また、楔部ではPADREの半定量的評価とアミロイドPETのSUV比の間にも有意な相関が認められました(相関係数 = 0.55; P値 = 0.02)。PADREはアミロイドPETのSUV比を予測する可能性が示唆され、ADの診断に有用であることが示唆されました。これらの研究成果は以下の論文に発表されました。Takita, et al. Magn Reson Med Sci. 2022 Jan 26. doi: 10.2463/mrms.mp.2021-0123.
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All Journal Article (136 results) (of which Peer Reviewed: 135 results, Open Access: 87 results) Presentation (213 results) (of which Int'l Joint Research: 37 results, Invited: 22 results) Book (37 results)
Internal Medicine
Volume: 63 Issue: 15 Pages: 2113-2123
10.2169/internalmedicine.2450-23
Volume: 63 Issue: 6 Pages: 803-807
10.2169/internalmedicine.2274-23
臨床放射線
Volume: 69 Issue: 2 Pages: 209-212
10.18888/rp.0000002643
Volume: 69 Issue: 2 Pages: 219-222
10.18888/rp.0000002645
Volume: 69 Issue: 1 Pages: 117-121
10.18888/rp.0000002620
Neuroradiology
Volume: - Issue: 6 Pages: 955-961
10.1007/s00234-024-03322-1
Scientific Reports
Volume: 14 Issue: 1 Pages: 2911-2911
10.1038/s41598-024-53278-8
Radiology Case Reports
Volume: 19 Issue: 1 Pages: 349-356
10.1016/j.radcr.2023.10.014
Volume: 19 Issue: 4 Pages: 1397-1400
10.1016/j.radcr.2023.12.059
Japanese Archive of cases conference of clinical nuclear medicine
Volume: 6 Pages: 1-6
医学のあゆみ
Volume: 287 Issue: 13 Pages: 978-984
10.32118/ayu28713978
Volume: 68 Issue: 10 Pages: 981-985
10.18888/rp.0000002478
Volume: 68 Issue: 10 Pages: 987-991
10.18888/rp.0000002479
臨床画像
Volume: 39 Issue: 13 Pages: 68-72
10.18885/CI.0000001259
Liver Cancer
Volume: 12 Issue: 6 Pages: 576-589
10.1159/000530441
Japanese Journal of Radiology
Volume: 41 Issue: 4 Pages: 393-400
10.1007/s11604-022-01370-2
Journal of Vascular and Interventional Radiology
Volume: 34 Issue: 5 Pages: 927-931
10.1016/j.jvir.2022.12.477
European Respiratory Review
Volume: 32 Issue: 168 Pages: 220259-220259
10.1183/16000617.0259-2022
Journal of Magnetic Resonance Imaging
Volume: 59 Issue: 4 Pages: 1341-1348
10.1002/jmri.28892
Radiology
Volume: 308 Issue: 1
10.1148/radiol.231040
Volume: 65 Issue: 8 Pages: 1239-1246
10.1007/s00234-023-03142-9
Volume: 308 Issue: 2
10.1148/radiol.223016
The Lancet Digital Health
Volume: 5 Issue: 8 Pages: e525-e533
10.1016/s2589-7500(23)00107-3
The Lancet Healthy Longevity
Volume: 4 Issue: 9 Pages: e478-e486
10.1016/s2666-7568(23)00133-2
Volume: 66 Issue: 1 Pages: 73-79
10.1007/s00234-023-03252-4
Volume: 41 Issue: 8 Pages: 789-806
10.1007/s11604-023-01400-7
Volume: 41 Issue: 8 Pages: 808-829
10.1007/s11604-023-01407-0
Neuropathology
Volume: - Issue: 5 Pages: 396-402
10.1111/neup.12898
Volume: 18 Issue: 9 Pages: 3037-3040
10.1016/j.radcr.2023.06.012
Volume: 18 Issue: 12 Pages: 4327-4330
10.1016/j.radcr.2023.08.096
Neurological Therapeutics
Volume: 40 Issue: 3 Pages: 218-222
10.15082/jsnt.40.3_218
Rinsho Shinkeigaku
Volume: 63 Issue: 7 Pages: 425-432
10.5692/clinicalneurol.cn-001855
Rad Fan
Volume: 21 Pages: 14-17
Volume: 18 Issue: 1 Pages: 200-204
10.1016/j.radcr.2022.10.003
PLOS ONE
Volume: 18 Issue: 2 Pages: e0281384-e0281384
10.1371/journal.pone.0281384
Academic Radiology
Volume: 30 Issue: 1 Pages: 30-39
10.1016/j.acra.2022.03.027
Magnetic Resonance in Medical Sciences
Volume: 22 Issue: 1 Pages: 67-78
10.2463/mrms.mp.2021-0123
130008144794
Volume: 67 Issue: 13 Pages: 1755-1758
10.18888/rp.0000002201
Volume: 67 Issue: 13 Pages: 1759-1763
10.18888/rp.0000002202
Volume: 38 Issue: 11 Pages: 1274-1282
10.18885/CI.0000001083
Volume: 67 Issue: 10 Pages: 1103-1106
10.18888/rp.0000002093
Volume: 67 Issue: 7 Pages: 713-717
10.18888/rp.0000002001
Volume: 61 Issue: 7 Pages: 959-967
10.2169/internalmedicine.8020-21
130008089765
Volume: 67 Issue: 3 Pages: 293-297
10.18888/rp.0000001880
日本門脈圧亢進症学会雑誌
Volume: 28 Pages: 204-207
日本臨床
Volume: 80巻増刊5 Pages: 69-77
Volume: 17 Issue: 12 Pages: 4679-4684
10.1016/j.radcr.2022.08.096
European Radiology
Volume: 32 Issue: 9 Pages: 5890-5897
10.1007/s00330-022-08752-0
The British Journal of Radiology
Volume: 95 Issue: 1140
10.1259/bjr.20220058
Hepatology Research
Volume: 53 Issue: 3 Pages: 228-237
10.1111/hepr.13855
Volume: 64 Issue: 9 Pages: 1869-1877
10.1007/s00234-022-02972-3
JGH Open
Volume: 6 Issue: 11 Pages: 754-762
10.1002/jgh3.12819
Journal of Digital Imaging
Volume: 36 Issue: 1 Pages: 178-188
10.1007/s10278-022-00691-y
European Journal of Radiology
Volume: 154 Pages: 110433-110433
10.1016/j.ejrad.2022.110433
Volume: S1051-0443 Issue: 7 Pages: 00123-3
10.1016/j.jvir.2022.03.010
Drug Metab Pharmacokinet
Volume: 44 Pages: 100449-100449
10.1016/j.dmpk.2022.100449
210000165366
Annals of Nuclear Medicine
Volume: 36 Issue: 5 Pages: 468-478
10.1007/s12149-022-01726-8
Volume: 17 Issue: 1 Pages: 156-160
10.1016/j.radcr.2021.10.011
Heliyon
Volume: 8 Issue: 1 Pages: e08741-e08741
10.1016/j.heliyon.2022.e08741
Volume: 12 Issue: 1 Pages: 727-727
10.1038/s41598-021-04667-w
Volume: 17 Issue: 4 Pages: 1120-1123
10.1016/j.radcr.2022.01.047
Volume: 17 Issue: 3 Pages: e0265751-e0265751
10.1371/journal.pone.0265751
Volume: 17 Issue: 3 Pages: 939-943
10.1016/j.radcr.2022.01.014
Volume: 66 Issue: 13 Pages: 1603-1607
10.18888/rp.0000001803
Volume: 66 Issue: 9 Pages: 949-953
10.18888/rp.0000001703
Volume: 66 Issue: 7 Pages: 725-728
10.18888/rp.0000001661
Volume: 66 Issue: 7 Pages: 707-711
10.18888/rp.0000001658
Volume: 66 Issue: 6 Pages: 605-608
10.18888/rp.0000001630
Volume: 66 Issue: 2 Pages: 157-160
10.18888/rp.0000001517
Case Reports in Radiology
Volume: 2021 Pages: 1-5
10.1155/2021/7970894
JCO Precision Oncology
Volume: 5 Issue: 5 Pages: 543-551
10.1200/po.20.00176
BMC Cancer
Volume: 21 Issue: 1 Pages: 1120-1120
10.1186/s12885-021-08847-9
Surgery Today
Volume: 52 Issue: 3 Pages: 414-419
10.1007/s00595-021-02370-x
Volume: 63 Issue: 10 Pages: 1739-1742
10.1007/s00234-021-02734-7
BJR|case reports
Volume: 7 Issue: 5 Pages: 20210011-20210011
10.1259/bjrcr.20210011
Volume: Online Issue: 3 Pages: 203692-203692
10.1148/radiol.2021203692
European Radiology Experimental
Volume: 5 Issue: 1
10.1186/s41747-020-00197-8
CardioVascular and Interventional Radiology
Volume: 5(1) Issue: 6 Pages: 1-1
10.1007/s00270-020-02751-8
Japanese Journal of Magnetic Resonance in Medicine
Volume: 40 Issue: 4 Pages: 129-142
10.2463/jjmrm.2020-1715
130007955973
Volume: 65 Issue: 6 Pages: 567-570
10.18888/rp.0000001259
40022291674
Volume: 65 Issue: 6 Pages: 571-575
10.18888/rp.0000001260
40022291719
BRAIN and NERVE
Volume: 72 Issue: 5 Pages: 493-508
10.11477/mf.1416201553
Gut
Volume: gutjnl-2020 Issue: 6 Pages: 322367-322367
10.1136/gutjnl-2020-322367
Volume: 44 Issue: 3 Pages: 475-481
10.1007/s00270-020-02686-0
Oncology
Volume: 99 Issue: 3 Pages: 1-6
10.1159/000510911
120007169288
CVIR Endovascular
Volume: 3 Issue: 1 Pages: 90-90
10.1186/s42155-020-00187-2
Volume: 39 Issue: 4 Pages: 333-340
10.1007/s11604-020-01070-9
210000161498
Volume: 38 Issue: 9 Pages: 860-869
10.1007/s11604-020-00984-8
50014592597
Volume: 65 Pages: 1039-1044
40022350462
Volume: 38 Issue: 6 Pages: 547-552
10.1007/s11604-020-00934-4
50014524564
肝・胆・膵
Volume: 80(5) Pages: 769-779
Volume: 93 Issue: 1108 Pages: 20190751-20190751
10.1259/bjr.20190751
Cardiovascular and interventional radiology
Volume: 43 Issue: 4 Pages: 565-571
10.1007/s00270-019-02399-z
The Official Journal of the Japanese Society of Interventional Radiology
Volume: 34 Issue: 4 Pages: 236-245
10.11407/ivr.34.236
130007837025
Volume: 19 Issue: 1 Pages: 5-6
10.2463/mrms.ci.2018-0152
130007796223
Volume: 58 Issue: 20 Pages: 2923-2929
10.2169/internalmedicine.2704-19
130007728759
Volume: 58 Issue: 16 Pages: 2291-2297
10.2169/internalmedicine.2356-18
130007690131
Clinical and Experimental Neuroimmunology
Volume: 10 Issue: S1 Pages: 32-48
10.1111/cen3.12501
Volume: 37 Issue: 7 Pages: 543-548
10.1007/s11604-019-00840-4
50014194390
Volume: 14 Issue: 8 Pages: 977-980
10.1016/j.radcr.2019.05.023
Abdominal radiology (New York)
Volume: 44 Issue: 10 Pages: 3377-3387
10.1007/s00261-019-02201-1
Osaka city medical journal
Volume: 65 Pages: 77-83
120006796093
日本インターベンショナルラジオロジー学会雑誌
Volume: 33 Pages: 398-401
Volume: 64 Pages: 853-858
Volume: 64 Pages: 841-845
Volume: 64 Pages: 1173-1179
Volume: 64 Pages: 1355-1359
Volume: 64 Pages: 1351-1354
Volume: 64 Pages: 1559-1563
Volume: 64 Pages: 67-71
Volume: 64 Pages: 61-65
Frontiers in Neurology
Volume: 9 Pages: 788-788
10.3389/fneur.2018.00788
Volume: 14 Issue: 3 Pages: 304-308
10.1016/j.radcr.2018.11.017
Volume: 290 Issue: 1 Pages: 187-194
10.1148/radiol.2018180901
Volume: 37 Issue: 4 Pages: 301-307
10.1007/s11604-019-00811-9
50013208190
Medical Practice
Volume: 35臨時増刊 Pages: 41-47
Volume: 63 Pages: 455-459
Volume: 63 Pages: 833-838
IVR: Interventional Radiology
Volume: 33 Pages: 243-251
130007662480
Volume: 33 Pages: 236-242
130007662487
Volume: 36 Issue: 6 Pages: 361-381
10.1007/s11604-018-0739-y
50012894422
BMC Research Notes
Volume: 11 Issue: 1 Pages: 251-251
10.1186/s13104-018-3358-x
AMERICAN JOURNAL OF NEURORADIOLOGY
Volume: 39 Issue: 7 Pages: 1239-1247
10.3174/ajnr.a5663
Volume: 36 Issue: 8 Pages: 472-476
10.1007/s11604-018-0751-2
50012952816
Osaka City Medical Journal
Volume: 64 Pages: 121-130
120006549642
Head & Neck
Volume: 61 Issue: 3 Pages: 739-747
10.1002/hed.25429
Volume: 37 Issue: 1 Pages: 15-33
10.1007/s11604-018-0795-3
210000170518
Volume: 17 Issue: 1 Pages: 58-66
10.2463/mrms.mp.2017-0035
130006306815
Jpn J Radiol.
Volume: 印刷中 Issue: 5 Pages: 233-241
10.1007/s11604-017-0626-y
50012595356
Acta Otolaryngol.
Volume: 印刷中 Issue: 8 Pages: 883-887
10.1080/00016489.2017.1293295
Neurol Sci.
Volume: 印刷中 Issue: 6 Pages: 1131-1133
10.1007/s10072-017-2879-8
J Contemp Brachytherapy
Volume: 9 Issue: 6 Pages: 499-507
10.5114/jcb.2017.72547
Volume: 36 Issue: 1 Pages: 23-29
10.1007/s11604-017-0693-0
210000179671
Volume: 35 Issue: 11 Pages: 629-647
10.1007/s11604-017-0678-z
50012797176
J Vasc Interv Radiol.
Volume: 28 Issue: 3 Pages: 477-479
10.1016/j.jvir.2016.11.092
Radiology.
Volume: 印刷中 Issue: 2 Pages: 391-398
10.1148/radiol.2016160414